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Increased production of reactive oxygen species (ROS) has been suggested as a cause of diabetic complications. Uncoupling proteins (UCPs) have been ascribed a role in reducing the formation of ROS, and genetic variation in genes encoding for UCPs could thus be putative candidate genes for diabetic nephropathy. To test this hypothesis we searched for association between the A→G (−3862) variant in U

Mute Swans (Cygnus olor) and Whooper Swans (Cygnus cygnus) in Sweden have been monitored as part of the International Waterbird Census (IWC) since 1967. For the Whooper Swan, midwinter indices show fluctuations around a slowly increasing trend. Country-wide surveys in 1971-72, 1988-89, 1995 and 2000, however found a more substantial increase in numbers, with national totals estimated at 2,000, 4,0

The asymptotic distribution of the maximum Mn=max1= 0 as t -> ~ or if Σr2t<~, then the limiting distribution is the same as for a sequence of independent normal variables. Here it is shown that this also follows from a weaker condition, which only puts a restriction

1. Studies of aquatic environments have shown that community organisation may strongly affect ecosystem functioning. One common phenomenon is a change in nutrient level following a shift in the fish community composition. Although several hypotheses have been suggested, there is no consensus on which mechanisms are involved. Our study evaluated indirect effects of benthivorous fish on the biogeoch

This article outlines experimental laboratory and field studies on creep of young or mature High Performance Concrete, HPC, carried out between 1991 and 1999. For this purpose about 400 cylinders made out of 8 mix compositions of HPC were studied in the laboratory. Half the number of HPC was sealed; half of the studies were carried out on air-cured HPC. Parallel tests on strength, internal relativ

Expression of the human cysteine proteinase inhibitor, cystatin C (CysC) in the cytoplasm of Escherichia coli was studied using a cDNA fragment encoding the cysteine proteinase inhibitor controlled by the phage λ pImage /cI857 system. The yield of CysC was low, probably due to proteolytic degradation. By fusing the cysC cDNA to a DNA fragment encoding the signal peptide of the E. coli outer membra

AIMS: To assess the effect of metformin on insulin sensitivity, glucose tolerance and components of the metabolic syndrome in patients with impaired glucose tolerance (IGT). METHODS: Forty first-degree relatives of patients with Type 2 diabetes fulfilling WHO criteria for IGT and participating in the Botnia study in Finland were randomized to treatment with either metformin 500 mg b.i.d. or placeb

Aims. This paper presents a new homogeneous catalogue of blue straggler stars ( BSS) in Galactic open clusters. Methods. Photometric data for 216 clusters were collected from the literature and 2782 BSS candidates were extracted from 76 of them. Results. We found that the anticorrelation of BSS frequency vs. total magnitude identified in similar studies conducted on Galactic globular clusters exte

Results from sorption measurements at 23 °C on Picea abies in the intervals 54 to 75% RH and 75 to 84% RH are reported. In the higher interval non-Fickian sorption is clearly seen.

Hip fracture is one of the most severe consequences of osteoporosis affecting aged women. However, abnormalities of bone turnover responsible for bone loss in this condition have not been clearly defined. To further evaluate the bone metabolic status of women sustaining hip fracture, we have prospectively measured serum osteocalcin as a marker of bone formation and urinary excretion of pyridinolin

Treating the source-separated organic fraction of municipal solid waste (SS-OFMSW) by anaerobic digestion is considered by many municipalities in Europe as an environmentally friendly means of treating organic waste and simultaneously producing methane gas. Methane yield can be used as a parameter for evaluation of the many different systems that exist for sorting and pre-treating waste. Methane y

Antibody evolution in vivo proceeds mainly by stepwise improvements, accomplished by single base pair substitutions. Lately, receptor revision, i.e. exchange of large parts of the V gene for another sequence, has been suggested to provide a complementary route for affinity maturation. By employing a receptor revision like evolution process in vitro using combinatorial libraries and phage display s

The photoinduced excited-state processes in 1,1'-diethyl-2,2'-cyanine iodine are investigated using femtosecond time-resolved pump-probe spectroscopy. Using a broad range of probe wavelengths, the relaxation of the initially prepared excited-state wavepacket can be followed down to the sink region. The data directly visualize the directed downhill motion along the torsional reaction coordinate and

The 28-kd plasma protein alpha(1)-microglobulin is found in the blood of mammals and fish in a free, monomeric form and as high-molecular-weight complexes with molecular masses above 200 kd. In this study, iodine 125-labeled free and high-molecular weight rat alpha(1)-microglobulin (a mixture of alpha(1)-microglobulin/alpha(1)-inhibitor-3 and alpha(1)-microglobulin/fibronectin complexes) were inje

Objective. Peritoneal adhesions develop after almost all surgical interventions in the abdomen. We have developed an efficient treatment against post-surgical adhesions consisting of a combination of positively charged poly-L-lysine and negatively charged poly-L-glutamate. The aim of the present study was to further develop the concept of applying oppositely charged polypeptides in the prevention

Lifetimes of a superdeformed band in Sr-82 were measured with the centroid shift method. The measured average quadrupole moment of this band corresponds to a quadrupole deformation of beta(2) approximate to 0.49, which is slightly smaller than both the theoretical prediction, and the measured deformation of the SD band in the neighboring isotone Zr-84. Lifetimes of high spin states of three normal