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BACKGROUND: Alcohol is an established risk factor for several cancers, but modest alcohol-cancer associations may be missed due to measurement error in self-reported assessments. Biomarkers of habitual alcohol intake may provide novel insight into the relationship between alcohol and cancer risk.METHODS: Untargeted metabolomics was used to identify metabolites correlated with self-reported habitua
Karst is a widespread ecosystem with properties that affect the microbial activity and storage and cycling of soil organic carbon. The mechanisms underlying microbial resource availability in karst, which limit the microbial growth and activity in soil aggregates, remain largely unknown. We assessed the microbial resource limitations using exoenzymatic stoichiometry and key extracellular enzyme ac
The article begins with a presentation of the role of demonstration and pantomime in the evolution of teaching building on Gärdenfors and Högberg (2017). In comparison to different forms of animal communication, demonstration is voluntary, intentional, honest, and directed to one or a few individuals. Then the differences between demonstration and pantomime is analyzed. An important factor is that
C-terminal α-amidation is the final and essential step in the biosynthesis of several peptide hormones. Peptidylglycine α-amidating monooxygenase (PAM) is the only known enzyme to catalyse this reaction. PAM amidating activity (AMA) is known to be present in human circulation, but its physiological role and significance as a clinical biomarker remains unclear. We developed a PAM-specific amidation
To maintain food security under global change, we need to consider the stability of ecosystem functioning into the future, particularly in resource production landscapes such as agricultural pasture. With ongoing climate change, extreme climatic events are predicted to become more frequent and severe globally, impacting crop production. The whole process of farming will become more uncertain, from
While many crystals, both natural and artificial, grow isotropically, there are examples of crystals growing anisotropically. The aim of this theoretical study was to confirm the growth modes displayed by three different crystals, representing 3D, 2D and 1D structures. This was done by using energetic calculations with both molecular mechanics, with ReaxFF$_{ \textrm {SiO}}$ as the force field, an
The research is done in order to analyse management of waste beverage containers in Belarus and the effectiveness of policies implemented to address it. The analysis is followed by exploring whether the introduction of deposit-refund system (DRS) would help to address packaging waste issue in Belarus and, if so, what features the DRS should possess to be effective in current context. The study des
Världens sötvattensystemen är sårbara och har upplevt betydande miljöförändringar. Utöver direkt mänsklig påverkan, innebär klimatförändringar ytterligare påfrestningar på våra färskvattenresurser. I denna studie undersöks hur klimatförändringar har påverkat tidsperioden av istäckning i svenska sjöar och vattendrag. Observationer från över 750 sjöar och vattendrag i Sverige har analyserats, med viThe worlds freshwater systems are vulnerable and have experienced significant environmental changes. In addition to direct anthropogenic impacts, climate change poses yet another source of pressure on the freshwater resources. This study investigates climate change impacts on ice cover duration in Swedish lakes and rivers. In situ observations from over 750 lakes and rivers in Sweden were analyzed
Vattenkraften står för hälften av vårt elbehov i Sverige idag. Merparten av vattenkraftverken är gjutna i betong och som många andra betongkonstruktioner så drabbas betongen av sprickbildning av olika orsaker. För vattenkraften är genomgående sprickor ett problem då dessa skapar läckage. För att förhindra dessa sprickor har en ny metod börjat undersökas där bakterier som kan avsätta kalciumkarbonHalf of the electricity needed in Sweden today is produced by hydro power. Most structure parts in hydro power stations are made of concrete and as many of other concrete structures they contain cracks. Cracking through dams are a big problem for hydro power since they create leakage. To prevent cracking a new method is under investigation. It consists of incorporating calcium carbonate precipita
China’s women’s movement is currently being reignited by diverse groups of young feminist activists. Given China’s authoritarian environment, these activists have condemned institutionalized efforts to achieve gender equality and instead adopted a noninstitutionalized approach through performance art, such as theatre and singing. This year marks the 20th anniversary of the 1995 Beijing Women’s Con
Previous studies have shown that increased incorporation of odd chain saturated fatty acids (OCFAs) into plasma phospholipids is associated with a lower future risk of developing type 2 diabetes and that decreased levels of OCFAs are linked to increased insulin resistance. Since the β-cell plays a pivotal role in the progression of type 2 diabetes it is of interest to investigate if elevated level
This essay studies the term privacy and its relation with the Mikrozensus survey, which is a survey conducted in Austria, amongst other countries, and forces chosen respondents by law to be part of the study. For the purpose of this essay, the questionnaire used for the Mikrozensus study published by Statistik Austria, which is the responsible institution for the survey, has been analysed using a
Technological advancements into the nanoscale have made it necessary to perform solid mechanical calculations on devices being produced on this scale. Traditionally, the field of continuum mechanics has been used to perform calculations in the field of solid mechanics, but the ubiquity of faster computers have opened up the field of peridynamics as an alternative. Peridynamic theory models materia
This thesis examines how moral discourse concerning FGM/C is articulated by the NGOs Amazonian Initiative Movement (AIM) and Advocacy Movement Network (AMNet) and with what consequences. It is a case study about these two organisations which uses content analysis as the main data collecting and analysing strategy. The theoretical framework describes the contemporary debate regarding FGM/C and cate
Acute myeloid and acute lymphoblastic leukemia (AML and ALL) harboring KMT2A rearrangements (KMT2A-R) constitutes a type of leukemia with inferior outcome and high likelihood of relapse, especially when occurring in infants < 1 year of age. We analyzed paired diagnose and relapse samples from Whole Genome Sequenced (WGS) and Whole Exome Sequenced (WES) data to model the genetic evolution from diag
