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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 192495 sökträffar

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Abstract Development and security have historically fashioned distinct discourses. More recently, they have been inevitably linked both in discourse and policy, having as a consequence the so-called development–security nexus. The goal of this paper is to examine the construction of notions and the establishment and consolidation of the discourses that the main theories that shape the field of

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Gränser mellan vegetationszoner fascinerar genom att på ett tydligt sätt påminna oss om sambanden som finns mellan det som lever och dess miljö. En av de mest påtagliga gränserna är den alpina trädgränsen, där fjällbjörkskogen gradvis övergår till kalfjäll. Den karga miljön som utgör kalfjället är starkt kopplat med temperatur och klimatförändringens ökade temperatur har medfört förändringar i träAerial photo interpretation shows a recent densification of trees has been occurring between 1960 and 2009 in the mountain birch (Betula pubescens ssp. czerepanovii) forest of the treeline ecotone in northern Swedish mountains. The correlation between treeline position and annual temperature is commonly accepted and advancing treelines are considered to be a useful indicator for monitoring climate

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The present work is an interdisciplinary and theoretical study on the topic of identity and the development of collective consciousness; an investigation of the ways in which people feel about and operate with their identities today. Identities are seen as a process circumscribed by the continuous struggle between the individual need for self-fulfillment and the demands of social structure and col

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The study seeks to examine the conceptualizations of space and scale in development thinking. One of the important dimensions of the development is the conceptualization of space and scale. The mainstream development theory, which is modernization, theorizes space as a physical geographical style that is technical and measurable. Scale on the other hand conceptualized on the nation state scale. Cr

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Fair Trade has noticed a new form of involvement for the public and the private sphere in relation to consumption. The aim of this study is to explore ethical consumption in relation to Fair Trade as well as the political aspect of it which has been relevant for supporting global causes and a form of citizen participation. The data collected for the study are an in-depth semi-structured interviews

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Globalization has lead to the situation that all countries in this or that way become affective by migratory movements. In year 2008 stream immigration to Sweden reached its record levels, with more than 100,000 people entering the country (Segregation 'widespread' for Swedish immigrants 2008). Although known to provide multiple benefits, such as new life opportunities, migration may also

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The increase of complexity of public services in the modern era proposes requirements for the coordination and cooperation between the public sectors. Inter department coordination mechanism is one of the very important part in government management and it becomes a global trend. No matter in the US, Japan, Korea or UK, setting up one kind of special organization to do the coordination between dif

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In 2001 the Doha Round Talks was initiated by the World Trade Organization. Development was the overarching goal. For several developing countries with a comparative advantage in agriculture, trade with such products is seen as essential to economic growth and thus development. In order to spur this development it appears to be particularly important that developing countries have increased access

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The Emissions Trading Scheme represents a new departure in the field of environmental policy-making in the EU. With it, the EU has deployed a market-based instrument to meet its Kyoto Carbon Dioxide emissions reduction commitments. This paper will account for its emergence as a concrete policy output. It will first refer to the historical, ideational and interest-based logics which shaped its emer

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Background Type 1 diabetes (T1D) is a cell-mediated autoimmune disease characterized by destruction of the pancreatic islet cells. The use of cryopreserved cells is preferable to the use of freshly isolated cells to monitor clinical trials to decrease assay and laboratory variability. Methods The T-Cell Workshop Committee of the Immunology of Diabetes Society compared two widely accepted T-cell fr

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A concept that lies at the heart of political rhetoric is that of ‘workfare’. The issue, however, is what types of arguments have been invoked to assert the value of the concept. During the 1960s and 1970s, extensive criticism emerged towards a working life that was said to hinder women’s emancipation; a working life that wasted resources and had a negative impact on the environment; a working lif

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Immunotherapy with intratumoral injection of adenoviral vectors expressing CD40L has yielded positive results in experimental and clinical bladder cancer. We therefore hypothesized that anti-CD40 antibody would be effective in this setting. Agonistic CD40 antibodies were developed as vaccine adjuvants but have later been used as treatment of advanced solid tumors and hematologic cancers. Systemic

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Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) are potent vasodilators in animals and humans. PACAP infusion but not VIP infusion precipitates migraine attacks in migraine patients. The vascular effects of VIP and the two varieties of PACAP (PACAP-27 and PACAP-38) were investigated versus selective antagonists in segments of rat middle cerebral arter

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Background The well-being of patients with Parkinson's disease may be improved by pharmaceutical care in community pharmacies. Objective To investigate the effects of standardised pharmaceutical care on health outcomes and quality of drug treatment in patients with Parkinson's disease. Setting Community pharmacies in Germany. Method An open-label, multicentre, longitudinal, parallel-group study wa

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Alloreactive memory T cells are major barriers to transplantation acceptance due to their capacity to accelerate rejection. Here, we investigated the effects of combined treatment with arsenic trioxide (As(2)O(3)) and blocking monoclonal antibodies (mAb) against CD154 and LFA-1 (anti-CD154/LFA-1) on graft survival as well as changes in pathology and immunological responses in mice with adoptively

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A recent genome-wide association study revealed a variant (rs2431697) in an intergenic region, between the pituitary tumor-transforming 1 (PTTG1) and microRNA (miR-146a) genes, associated with systemic lupus erythematosus (SLE) susceptibility. Here, we analyzed with a case-control design this variant and other candidate polymorphisms in this region together with expression analysis in order to cla

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Narcolepsy is a lifelong sleep disorder related to hypocretin deficiency resulting from a specific loss of hypocretin-producing neurons in the lateral hypothalamic area. The disease is thought to be autoimmune due to a strong association with HLA-DQB1*06:02. In 2009 the World Health Organization (WHO) declared the H1N1 2009 flu pandemic (A/H1N1PDM09). In response to this, the Swedish vaccination c

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A wealth of biospecimen samples are stored in modern globally distributed biobanks. Biomedical researchers worldwide need to be able to combine the available resources to improve the power of large-scale studies. A prerequisite for this effort is to be able to search and access phenotypic, clinical and other information about samples that are currently stored at biobanks in an integrated manner. H