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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 113984 sökträffar

Which prior knowledge? : Quantification of in vivo brain 13C MR spectra following 13C glucose infusion using AMARES

The recent developments in high magnetic field 13C magnetic resonance spectroscopy with improved localization and shimming techniques have led to important gains in sensitivity and spectral resolution of 13C in vivo spectra in the rodent brain, enabling the separation of several 13C isotopomers of glutamate and glutamine. In this context, the assumptions used in spectral quantification might have

Design of two-column batch-to-batch recirculation to enhance performance in ion-exchange chromatography

Preparative liquid chromatography is a separation technique widely used in the manufacturing of fine chemicals and pharmaceuticals. A major drawback of traditional single-column batch chromatography step is the trade-off between product purity and process performance. Recirculation of impure product can be utilized to make the trade-off more favorable. The aim of the present study was to investiga

Experimental investigations of potassium chemistry in premixed flames

Quantitative potassium species concentrations have been measured in alkali-seeded premixed methane-air flames of different stoichiometry. Potassium chloride (KCl) and hydroxide (KOH) were measured by broadband UV absorption spectroscopy and laser-induced photofragmentation fluorescence, while atomic potassium was measured using tuneable diode-laser spectroscopy. In addition, laser Rayleigh scatter

Differences in biomarkers of cartilage matrix turnover and their changes over 2 years in adolescent and adult volleyball athletes

BACKGROUND: This study aimed the feasibility to assess longitudinal changes in biomarkers of cartilage turnover and to determine their relationship with patient-rated outcomes over 2 years in volleyball athletes.METHODS: Thirty-seven athletes were studied: 18 adolescents (age 15.9 ± 0.64 years) in a 2-year intensive volleyball training program and 19 adult recreational volleyball players (age 46.5

Pre- and post-migration labour market mismatch in Sweden 1970-1990

Labour market outcomes for immigrants in general is a well researched field, but the mechanisms behind labour market mismatches among immigrants post-migration is still in need of empirical research. Using a unique and newly compiled dataset on Swedish immigrants, also containing pre-migration occupational and educational information data, this study aims makes use of maximum likelihood models to

HFMADM method based on nondimensionalization and its application in the evaluation of inclusive growth

Inclusive growth, which encompasses different aspects of life, is a growth pattern that allows all people to participate in and contribute to growth process. In this paper, a novel hesitant fuzzy multiple attribute decision making (HFMADM) approach based on the nondimensionalization of decision making attributes is presented and then applied to the evaluation of inclusive growth in China. Firstly,

On the interaction between single chain Fv antibodies and bacterial immunoglobulin-binding proteins

Using four bacterial immunoglobulin-binding proteins, we have analyzed the binding characteristics of a panel of 34 human single chain Fv antibodies, expressed in E. coli and with known specificity and sequence. Several of the single chain Fv antibodies showed affinity for staphylococcal protein A and peptostreptococcal protein L, but not for the streptococcal proteins G or H. The affinity of the

Chlorosis during nitrogen starvation is altered by carbon dioxide and temperature status and is mediated by the ClpP1 protease in Synechococcus elongatus

The interactive effects of inorganic carbon status, temperature and light on chlorosis induced by nitrogen deficiency, and the roles of Clp proteases in this process were investigated. In wild-type cultures grown in high or ambient CO(2), following transfer to media lacking combined nitrogen, phycocyanin per cell dropped primarily through dilution of the pigment through cell division, and also suf

Solid and fluid segments within the same molecule of stratum corneum ceramide lipid

The outer layer of the skin, stratum corneum (SC) is an efficient transport barrier and it tolerates mechanical deformation. At physiological conditions, the majority of SC lipids are solid, while the presence of a small amount of fluid lipids is considered crucial for SC barrier and material properties. Here we use solid-state and diffusion nuclear magnetic resonance to characterize the compositi

Synthesis, Morphological, and Electro-optical Characterizations of Metal/Semiconductor Nanowire Heterostructures

In this letter, we demonstrate the formation of unique Ga/GaAs/Si nanowire heterostructures, which were successfully implemented in nanoscale light-emitting devices with visible room temperature electroluminescence. Based on our recent approach for the integration of InAs/Si heterostructures into Si nanowires by ion implantation and flash lamp annealing, we developed a routine that has proven to b

Science audited: Indicator-based systems for research evaluation and resource allocation

This paper presents an ongoing research project investigating the use of bibliometrics for research evaluation and resource allocation purposes, and to investigate the effects of these evaluation models on individual, organizational and political levels. A main focus has been on bibliometrics based evaluation practices. The use of bibliometrics for local resource allocation at Swedish universities

The red blood cell count and the erythrocyte sedimentation rate in the diagnosis of polycythaemia vera

BACKGROUND: Iron deficiency in polycythaemia vera (PV) may impact the validity of the haematocrit (HCT), since HCT is red blood cell count (RBC) × mean corpuscular volume (MCV).OBJECTIVES: To investigate (a) the effect of microcytosis on HCT, (b) the erythrocyte sedimentation rate (ESR) as a possible additional diagnostic marker for PV.MATERIAL AND METHODS: This study included 182 subjects: 39 wit

Circular Migration and the Rights of Migrant Workers in Central and Eastern Europe : The EU Promise of a Triple Win Solution

This open access book adopts a rights-based approach to shed light on the different legal and policy instruments that have been developed to implement circular migration policies in the EU, and their consequences for the rights of migrant workers. It contributes to the understanding of the meaning of this concept in general and in the EU, as well as specifically regarding its Eastern neighborhood.

Impact of treatment strategy and physical performance on future knee-related self-efficacy in individuals with ACL injury

Background: In people with anterior cruciate ligament (ACL) injury, high self-efficacy facilitates recovery, indicated by improved muscle function, reduced knee symptoms and increased physical activity. Impact of treatment on future self-efficacy is however not well investigated. The aims of the study were to 1) investigate knee-related self-efficacy 6 years after acute ACL injury in patients trea

Technical and conceptual considerations for using animated stimuli in studies of animal behavior

Rapid technical advances in the field of computer animation (CA) and virtual reality (VR) have opened new avenues in animal behavior research. Animated stimuli are powerful tools as they offer standardization, repeatability, and complete control over the stimulus presented, thereby "reducing" and "replacing" the animals used, and "refining" the experimental design in line with the 3Rs. However, ap

Generation of human walking paths

This work investigates the way humans plan their paths in a goal-directed motion, assuming that a person acts as an optimal controller that plans the path minimizing a certain (unknown) cost function. Taking this viewpoint, the problem can be formulated as an inverse optimal control one, i.e., starting from control and state trajectories one wants to figure out the cost function used by a person w

Quantitative 3D imaging of scattering media using structured illumination and computed tomography

An imaging technique capable of measuring the extinction coefficient in 3D is presented and demonstrated on various scattering media. The approach is able to suppress unwanted effects due to both multiple scattering and light extinction, which, in turbid situations, seriously hampers the performance of conventional imaging techniques. The main concept consists in illuminating the sample of interes

Sustainable machining through increasing the cutting tool utilization

Several previous articles have discussed different approaches to improving sustainability during machining operations. However, more effective utilization of cutting tools is an approach that has been overlooked in previous investigations. Increasing the effectiveness of cutting tool utilization decreases the need for new tools as well as the resources and energy needed to produce new cutting tool