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OBJECTIVES: Cyclophosphamide (CP) is an alkylating agent classified as a human carcinogen. Health care workers handling this drug may be exposed during, e.g., preparation or administration. Cyclophosphamide is readily absorbed by inhalation and by dermal uptake. A biomarker, CP in urine, has frequently been used to assess the occupational exposure to CP, but has not been fully validated. The aim o

The flash electroretinogram (ERG) was used to characterize the scotopic retinal function in a marsupial. Key parameter values of the a- and b-waves of adult male sugar gliders, Petaurus breviceps breviceps, elicited with ganzfeld flashes were determined under dark-and light-adapted conditions. Using standard histological methods, the thicknesses of the major layers of the retina were assessed to p

Global climate change increases heat loads in urban areas causing health and productivity risks for millions of people. Inhabitants in tropical and subtropical urban areas are at especial risk due to high population density, already high temperatures, and temperature increases due to climate change. Air conditioning is growing rapidly, especially in South and South-East Asia due to income growth a

Popular Abstract in Swedish Sjukdomsuppfattningar. Värderingar och attityder hos patienter och medicine studerande. Utvecklingen av den biomedicinska kunskapen och de demografiska förändringarna under 1900-talet har inneburit en ökning av såväl behov av som efterfrågan på hälso- och sjukvård. Illabefinnande utan påvisbara sjukdomstecken och rädsla för sjukdom ligger ofta bakom vårdsökande. OfficieDuring the 20th century, the development of biomedical knowledge and the demographical changes have increased the needs and demands for health care in industrialised countries. Illness without evidence of disease and fear of disease are often the reasons for seeking medical care. Primary care is the official foundation of the Swedish health care system but priorities are vague and frequently chang

Popular Abstract in Swedish Denna avhandling fokuserar förändringar inom den arbetsmarknadspolitik som erbjuds arbetslösa socialbidragstagare mellan 1989 och 2002 i Sverige. Denna förändring beskrivs som en process där kommunerna tar allt mer ansvar för arbetsmarknadspolitiken. Denna grupp arbetslösa kategoriseras som en speciellt problematisk grupp och hänvisas till kommunerna. Detta sker utan tyThis dissertation focuses on changes in labour market policies that were provided for unemployed recipients of social assistance between 1989 and 2002 in Sweden. This change is described as a process where the municipalities gradually take greater responsibility for the labour market policies. This group of unemployed is categorized as a particularly problematic group and has been referred to the

Objective: To evaluate risk factors - notably drugs - for developing acute pancreatitis. Methods: A population-based, case-control study, encompassing 1.4 million inhabitants aged 20-85 years from four regions in Sweden between 1 January 1995 and 31 May 1998. A total of 462 cases were hospitalised in surgical departments with their first episode of acute pancreatitis without previously known bilia

In this study, we present a simple and easy-to-use extraction method that is based on a hollow-fiber microporous membrane liquid-liquid extraction (HF-MMLLE), as an extraction technique, followed by gas chromatography-mass spectrometry (GC-MS) to determine a group of brominated flame retardants (BFRs), polybrominated diphenyl ethers (PBDEs), at trace levels in aqueous samples. The hollow-fiber mem

Cellulose, a polysaccharide consisting of beta-1,4-linked glucose, is the major component of plant cell walls and consequently one of the most abundant biopolymers on earth. Carbohydrate polymers such as cellulose are molecules with vast diversity in structure and function, and a multiplicity of hydrolases operating in concert are required for depolymerisation. The bacterium Rhodothermus marinus,

Popular Abstract in Swedish Denna doktorsavhandling behandlar de 450-440 miljoner år gamla marina sediment som idag påträffas i form av deformerade och uppveckade sedimentära bergarter vid randen av den svenska fjällkedjan i Jämtland. Målet med studien har varit att kartlägga och tolka hur, och i vilken utsträckning, lokala och globala händelser påverkat de depositionsmiljöer som sedimenten avlagrThis thesis is based on studies of Lower Palaeozoic sedimentary successions within the central Scandinavian Caledonides. These deposits have been transported by considerable nappe displacement (several kilometres), and are today relatively isolated from the nearest coeval outcrops (Dalarna 250 km, Oslo Region 350 km). As a consequence, and due to the previously limited biostratigraphical control t

Despite the fact that it has been used since the 1960s in diseases associated with brain edema and has been investigated in >150 publications on head injury, very little has been published on the outcome of osmotherapy. We can only speculate whether osmotherapy improves outcome, has no effect on outcome, or leads to worse outcome. Here we describe the action and potentially beneficial and adverse

Studies were conducted in human isolated coronary arteries to explore the vascular effects of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant, and to compare its coronary vasoconstrictive potential to that of zolmitriptan. KCl-precontracted coronary vessels were shown to relax to human alphaCGRP, with the CGRP-mediated vasorelaxation completely blocked with 30 muM telcag

We report on the electronic structure of nano-crystalline Fe:ZnO, which has recently been found to be an efficient photocatalyst. Using resonant photoemission spectroscopy, we determine the binding energy of Fe 3d states corresponding to different valencies and coordination of the Fe atoms. The photo-activity of ZnO reduces Fe from 3+ to 2+ in the surface region of the nano-crystalline material du

Purpose: This study was intended to evaluate a multi-professional health-promoting and disease-preventive intervention organized as multi-professional senior group meetings, which addressed home-dwelling, independently living, cognitively intact elderly persons (80 +/-), by exploring the participants' experiences of the intervention. Method: The focus group methodology was used to interview a tota

Visual performance and visual interactions in pelagic animals are notoriously hard to investigate because of our restricted access to the habitat. The pelagic visual world is also dramatically different from benthic or terrestrial habitats, and our intuition is less helpful in understanding vision in unfamiliar environments. Here, we develop a computational approach to investigate visual ecology i

The Tunisian Dorsal area is representative of the semiarid Mediterranean region in terms of water resources availability as well as exceptional rainfall characteristics, runoff generation, and soil loss risk. In this context, soil properties, surface management practices together with highly intensive rainfall make the soils vulnerable to erosion. If the exceptional rainfall characteristics are li