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Natural and synthetic sugars have great potential for developing highly biocompatible and translatable chemical exchange saturation transfer (CEST) MRI contrast agents. In this study, we aimed to develop the smallest clinically available form of dextran, Dex1 (molecular weight, MW ~ 1 kDa), as a new CEST agent. We first characterized the CEST properties of Dex1 in vitro at 11.7 T and showed that t
Effective microbial bioprocessing relies on maintaining ideal cultivation conditions, highlighting the necessity for tools that monitor and regulate cellular performance and robustness. This study evaluates a fed-batch cultivation control system based on at-line flow cytometry monitoring of intact yeast cells having a fluorescent transcription factor-based redox biosensor. Specifically, the biosen
Benign prostatic hyperplasia (BPH) is a feature of ageing males. Up to half demonstrate bladder outlet obstruction (BOO) with associated lower urinary tract symptoms (LUTS) including bladder overactivity. Current therapies to reduce obstruction, such as α1-adrenoceptor antagonists and 5α-reductase inhibitors, are not effective in all patients. The phosphodiesterase-5 inhibitor (PDE5I) tadalafil is
RATIONALE AND OBJECTIVES. The authors evaluate the feasibility of differential imaging of contrast media, with division of individual pixel values obtained from digital images generated by characteristic radiation from a laser-produced plasma, bridging the K-absorption edge of the contrast agent. METHODS. Laser pulses from an ultrashort-pulse terawatt laser system were focused onto gadolinium and
Efficient heat dissipation that can minimize temperature increases in device is critical in realizing electrical injection lasers. High-thermal-conductivity diamonds are promising for overcoming heat dissipation limitations for perovskite lasers. In this study, we demonstrate a perovskite nanoplatelet laser on a diamond substrate that can efficiently dissipate heat generated during optical pumping
During 2014, an attack called the BadUSB attack surfaced. This attack allows the attacker to reflash the firmware of a USB devices and make it perform malicious tasks. One particularly interesting attack whose source code has been released recently includes modifying a USB flash drive into also acting as a keyboard thus enabling it to send malicious keystrokes. This thesis presents a modified ver
Heavy-duty vehicles of today consist of much electronics and many sensors. One of these sensors is a longitudinal accelerometer. This Master's thesis investigates the possibilities to determine the road slope angle with a longitudinal accelerometer. With the knowledge of current road slope angle, many other control systems in the trucks can be improved. The optimization of these control system
The Multi-Blade is a Boron-10-based neutron detector designed for neutron reflectometers and developed for the two instruments (Estia and FREIA) planned for the European Spallation Source in Sweden. A demonstrator has been installed at the AMOR reflectometer at the Paul Scherrer Institut (PSI - Switzerland). AMOR exploits the Selene guide concept and can be considered a scaled-down demonstrator of
An incremental high-cycle fatigue damage model is combined with topology optimization to design structures subject to non-proportional loads. The optimization aims to minimize the mass under compliance and fatigue constraints. The fatigue model is based on the concept of an evolving endurance surface and a system of ordinary differential equations that model the local fatigue damage evolution. A r
Framtidens cancersjukvård kommer att omfatta individuell kartläggning av mutationer i tumörcellernas DNA för att matcha varje patient till rätt behandling. Därför måste vi bättre förstå vilka mutationer som är viktiga. Idag ligger fokus helt på de mutationer som är enklast att tolka medan så kallade ”tysta” eller synonyma mutationer som inte direkt förändrar ett protein filtreras bort. Även synony
The aim of this study was to establish if repeated quantitative 201Tl SPET scanning during follow-up of astrocytoma therapy can provide information that is relevant for clinical management. Sixteen consecutive patients, with histopathologically verified highly malignant astrocytoma, were followed during PCV chemotherapy. Imaging with 201Tl SPET and CT was performed repeatedly over 8-16 weeks until
14 oktober 2025 17:00 | Konsert This October, Malmö Academy of Music is honoured to welcome distinguished colleagues from Kharkiv I.P. Kotlyarevsky National University of Arts as part of the Erasmus+ programme. Join us for two extraordinary evenings of classical music celebrating artistic excellence, cultural exchange, and solidarity.✨ Concert 1📍 Rosenberg Hall, Malmö Academy of Music🗓 October 1
https://www.lu.se/evenemang/kharkiv-malmo-welcoming-ukrainian-musicians-malmo-academy-music - 2026-07-18
The maximum likelihood principle of estimation applied to the linear black-box identification problem gives models with theoretically attractive properties. Also, the method has been applied to industrial data (various processes in paper production) and proved able to work in practice.This paper presents further developments of the method in the case of a single output. The reliability and speed o
Particle-gammagamma and gammagamma-coincidences of the reaction Ni-58(Ar-36, 4 pn)89Mo have been used to gain more information about high spin states in 89Mo and to establish the yrast sequence up to 7.6 MeV excitation energy and probable spin 37/2 h. Spins and parities were assigned on the basis of DCO-ratios measured with the OSIRIS spectrometer and a large volume Ge detector placed at 162-degre
This report deals with the identification of ATP/ADP translocase genes. In rickettsial species such as Rickettsia prowazekii, which is the cause of epidemic typhus in humans, the utilisation of host cell ATP is the major way that this bacterium employ its toxicity in the host cell. This obligate intracellular bacterium is an energy-parasite. In the genome of R. prowazekii there are five homologs o
