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The Big Tech companies, more precisely the five American giants: Google, Apple, Facebook, Amazon and Microsoft, have been performing a massive number of startup acquisitions and strengthening their dominant position in the market. In an economical study about mergers in the pharmaceutical sector the term killer acquisition was firstly adopted to define a transaction in which an incumbent, after ac
Pseudouridylation (Ψ) is the most abundant and widespread type of RNA epigenetic modification in living organisms; however, the biological role of Ψ remains poorly understood. Here, we show that a Ψ-driven posttranscriptional program steers translation control to impact stem cell commitment during early embryogenesis. Mechanistically, the Ψ “writer” PUS7 modifies and activates a novel network of t
To achieve high selectivity in directed C–H activation, an NHC ligand was introduced to a palladium catalyst. A range of Pd-PEPPSI complexes were applied in the direct acetoxylation of 2-phenylpyridine. The best catalyst was found to be the one based on a diisopropylphenyl-substituted NHC ligand, and this was successfully used for the functionalization of sp2as well as more challenging sp3bonds fo
This paper deals with a two-echelon spare parts inventory system with one central warehouse and a number of local warehouses facing Poisson demand. Normally, the local warehouses replenish stock from the central warehouse. However, if a demand cannot be satisfied within a pre-determined time window, an emergency shipment is requested from an outside supplier. Moreover, as in practice, this outside
The ability of chevrons at the top edge of a backward-facing step to reduce downstream surface pressure fluctuations is investigated numerically. Three different chevron configurations are compared against a baseline case without chevrons. Low frequency reduction in the surface pressure fluctuations is observed for two of the configurations. The chevrons do not appear to have a significant effect
ln this article, we analyze fertility control in a rural population characterized by natural fertility, using survival analysis on a longitudinal data set at the individual level combined with food prices. Landless and semilandless families responded strongly to short-term economic stress stemming from changes in prices. The fertility response, both to moderate and large changes in food prices, wa
The present study investigated the relation between imagination, motivation and locus of control. The participants were 95 children (53 girls and 42 boys) born between 1998 and 2001. Motivation was measured using “Achievement Goal Questionnaire” and theoretical background on motivation was oriented in “Achievement Goal Theory”. “Mastery goal orientation” (goal to develop ability) was hypothesized
Chinese women have, by international standards, a comparatively low rate of birth control pill use. This study attempts, through interviews with social scientists and pharmacy surveys, to determine why women do not choose contraceptive pills more often. Interviews with patients and doctors reveal that there are several factors which combine to strongly dissuade women from using birth control pills
Summary. Despite improvements in therapy that has greatly enhanced the treatment of patients with haemophilia with inhibitors, they are still at risk of poorer outcomes including haemophilic arthropathy and long-term disability. The objective of this review is to consider clinical data on the effect of rapid control of bleeding episodes on outcomes in these patients. Rapid control of bleeding epis
Splicing and translation are two of the key steps of post-transcriptional regulation of gene expression. Their tight regulation is essential for development, whereas their deregulation is involved in cancer pathogenesis. Nevertheless, many of the molecular mechanisms controlling these processes are still unknown. Hence, the main aim of this thesis is to elucidate novel regulatory mechanisms that a
In the design of a wave energy converter (WEC) in general, one critical aspect is to develop thepower take-off (PTO) system since it has a significant impact on the overall energy harnessing efficiency. There-fore, the modelling of a PTO system should be considered in the simulation of a WEC and carefully tuned with itsparameters to guarantee prediction accuracy. However, it is a challenge to mode
Dizziness and subjective balance disturbances are frequent complaints in cervical pain syndromes of different origins. We objectively assessed balance function with posturography using vibration-induced and galvanically induced body sway in consecutive patients with cervicobrachial pain syndrome of more than 3 months duration. Both a group of patients with MRI-verified cervical root compression (C
Aerosol growth of semiconductor nanowires has the potential to dramatically lower the cost of for solar cell production. The objective of the work was to study the growth of aerosol nanoparticles and nanowires, in order to understand the chemical and physical processes involved. This was accomplished by studying the early parts of growths using optical diagnostic techniques. The work involved deve
