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Molekylär Neurofysiologi och Epilepsi

Epilepsy is a devastating neurological disorder characterized by synchronous neuronal activity, which manifests as epileptic seizures. It usually develops after an initial insult, such as head trauma or stroke, which triggers the epileptogenic process. During epileptogenesis, the affected brain regions undergo multiple changes in connectivity and gene expression, and among the most affected genes Epilepsy is a devastating neurological disorder characterized by synchronous neuronal activity, which manifests as epileptic seizures. It usually develops after an initial insult, such as head trauma or stroke, which triggers the epileptogenic process. During epileptogenesis, the affected brain regions undergo multiple changes in connectivity and gene expression, and among the most affected genes

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Fluorescence spectroscopy in two different biomedical applications have been studied. One field has been to explore whether fluorescence spectroscopy can be used to determine the depth of a fluorescent object inside a tissue-like medium. Recorded fluorescence spectra depend on the localisation of the fluorescent inclusion and may provide additional information for optical tomography. The second ma

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The complexity of the brain, in which different neuronal cell types are interspersed and complexly interconnected, has posed a major obstacle in identifying pathophysiological mechanisms underlying prevalent neurological disorders. This is largely based in the inability of classical experimental approaches to target defined neural populations at sufficient temporal and spatial resolution. As a con

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Nonlinear discrete-time modeling of a Web server system is investigated. Server systems typically contain nonlinearities such as saturations and bounded queue lengths. The incoming traffic and service rates are best modeled by stochastic processes, well described and analyzed by queuing theory. Here, we develop and validate a control theoretic model of a general single server queue, a so-called G/

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OBJECTIVE - To analyze the effect of antibodies to glutamic acid decarboxylase (GAD65Ab) and islet cells (ICA512Ab) on glycemic control early in IDDM. RESEARCH DESIGN AND METHODS - GAD65Ab and ICA512Ab were measured twice in 35 patients (10 male, 25 female; age 1040 years) initially within 2 years of diagnosis and again 1 year later. The glycosylated hemoglobin was measured one to four times each

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The feasibility of mode control in rotating detonation engine is investigated through regulating the global equivalence ratio during the test under different air mass flow rates, chamber lengths, and blockage ratios at the exit, including the mode transitions between the single wave and two co-rotating waves, two counter-rotating waves and longitudinal pulsed detonation, two co-rotating waves and

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Recently, molecular motor gliding assays with actin and myosin from muscle have been realized on semiconductor nanowires coated with Al2O3. This opens for unique nanotechnological applications and novel fundamental studies of actomyosin motor function. Here, we provide a comparison of myosin-driven actin filament motility on Al2O3 to both nitrocellulose and trimethylchlorosilane derivatized surfac

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The public sector in Sweden has been an early adopter of public management reforms and the health care sector has been in the forefront of the development. In recent years, process orientation has been one key component in this endeavour. Studies in two health care organizations show that an increased focus on horizontal processes leads to changes in the management control system. However, it also

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This doctoral thesis consists of six studies concerning persons with insulin dependent diabetes mellitus (IDDM). The first two deal with relationships between life events, social support and metabolic control (HbA1C) over a two year period. For the female subjects, results obtained for this period were inconsistent. For the male group, negative life events and poor social support were found to be

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Web breaks in the dryer section of a paper machine cause loss of production and quality problems. After a web break, the steam pressure in the cylinders must be reduced to avoid overheating. The goal of this project is to determine optimal steam pressure trajectories during web breaks, so that the production is restarted with the same drying properties of the cylinder as before the break. A detail

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In literature there is a great variety of detective novels and The Secret History is one that presents the whydunnit-plot pattern, as the murderers are exposed early on. Another extensive part of The Secret History is its connection to Greek tragedies and Dionysian influences. Therefore these are considered and part of the formulation of this paper. I aim to establish ‘control’ as a unifying theme

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In Western blotting, immunodetection of housekeeping proteins is routinely performed to detect differences in electrophoresis loading. The present work describes a much faster and simpler protein staining method, which is compatible with ordinary blocking conditions. In addition, the method can be used after immunodetection with superior linearity compared to ordinary staining methods. After immun