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Evaluation schemes, e.g., least-squares fitting, are not generally applicable to any types of experiments. If the evaluation schemes were not derived from a measurement model that properly described the experiment to be evaluated, poorer precision or accuracy than attainable from the measured data could result.. We outline ways in which statistical data evaluation schemes should be derived for all

The complex [(bipy)2Ru(dpp)][PF6]2 which contains a vacant 2,2′-bipyridine-like metal-binding domain has been structurally characterised. This compound is a key building block for the construction of metallodendrimers using the “complexes as metals, complexes as ligands” approach.

The most precise method of investigating possible space-time variations of the fine-structure constant, alpha equivalent to (1/hc)(e(2)/4 pi epsilon(0)), using high-redshift quasar absorption lines is the many-multiplet (MM) method. For reliable results this method requires very accurate relative laboratory wavelengths for a number of UV resonance transitions from several different ionic species.

Recent investigations show that the pollen accumulation rate (PAR) of the common tree taxa is directly related to the biomass and, by inference, to the population size of the taxa around the study site. Fossil PAR records preserved in lakes provide therefore a potential proxy for quantitative biomass and population reconstructions. We use the high-resolution PAR records obtained from two accuratel

A structure determination in combination with a kinetic study of the steroid converting isozyme of horse liver alcohol dehydrogenase, SS-ADH, is presented. Kinetic parameters for the substrates, 5β-androstane-3β,17β-ol, 5β-androstane-17β-ol-3-one, ethanol, and various secondary alcohols and the corresponding ketones are compared for the SS- and EE-isozymes which differ by nine amino acid substitut

Comparative analysis of expressed sequence tags is becoming an important tool in molecular ecology for comparing gene expression in organisms grown in certain environments. Additionally, expressed sequence tag database information can be used for the construction of DNA microarrays and for the detection of single nucleotide polymorphisms. For such applications, we present PHOREST, a web-based tool

Aqueous extract of Clinopodium vulgare L. showed strong antitumour activity when tested in vitro on A2058 (human metastatic melanoma), HEp-2 (epidermoid carcinoma, larynx, human) and L5178Y (mouse lymphoma) cell lines-6 h after treatment disintegration of the nuclei and cell lysis started. Applied at a concentration of 80 microg/ml it reduced the cell survival to 1.0, 5.6 and 6.6%, respectively. T

This article reviews the problem of bleeding in connection with epidural/spinal anaesthesia, with special emphasis on the use of low molecular weight heparins for thromboprophylaxis. There are methodological difficulties to studying the problem in a scientifically correct way because of the rarity of the complication. However, from the data in the literature there are no indications of an increase

A box graph is the intersection graph of orthogonal rectangles in the plane. We consider such basic combinatorial problems on box graphs as maximum independent set, minimum vertex cover and maximum induced subgraph with polynomial-time testable hereditary property Pi. We show that they can be exactly solved in subexponential time, more precisely, in time 2(O(rootnlog n)), by applying Miller's simp

Molecularly imprinted polymer coatings were synthesized in fused-silica capillary columns by the use of a surface-coupled radical initiator. The coatings were prepared using either toluene, dichloromethane, or acetonitrile in the prepolymerization mixtures and were 0.15-2 microm thick as determined by scanning electron microscopy. Solvent-dependent differences in appearance were observed. All the

Here, a conceptual model is presented for the development of Phytophthora disease in pedunculate oak. The model is presented using the causal loop diagram tool and gives an overview of how various abiotic and biotic factors, such as soil moisture, nutrient availability and mycorrhizal colonization, may affect the reproduction and the infective capacity of soil-borne Phytophthora species, the susce

Background A growing body of evidence suggests that migration is a risk factor for the development of schizophrenia, although the putative mechanism remains obscure. Aims To examine immigrant background and history of foreign residence as risk factors for schizophrenia. Method Using data from the Danish Civil Registration System, we established a population-based cohort of 2.14 million persons r

Writers typically spend a certain proportion of time looking back over the text that they have written. This is likely to serve a number of different functions, which are currently poorly understood. In this article, we present two systems, ScriptLog+ TimeLine and EyeWrite, that adopt different and complementary approaches to exploring this activity by collecting and analyzing combined eye movemen

The present communication concerns factors, the application of which may contribute to reduce the transfer rate of sexually transmitted infections (STIs), including geomedical aspects. The factors elaborated on are, e.g. maternal health care, sexual education early in life, health prevention programmes and sexual risk reduction counselling of commercial sex workers, screening activities as well as

The number and diversity of chemicals produced and used in society today are growing in conjunction with the both evident and uncertain environmental impacts associated with the life cycles of these chemicals. Chemical management services (CMS) is a business strategy based on a strategic, long-term contract, according to which the supplier of chemical management services accepts the responsibility

The admission control mechanism is an important part of many communication systems. In this paper we investigate load control mechanisms for server systems, that is systems that may be modelled as queueing systems. We show how control theory can be used when designing controllers for a G/G/1-system. We design a PI-controller for the system and compare the steady-state and transient behavior of thi

This paper describes the development of a prototype product named MAGIC-HAND that has been developed to open bottles, jars and packages that require a twisting action. Its intended users are people with severe disabilities, who are not capable of using the current range of package opening tools. MAGIC-HAND is a kitchen accessory device that fits into standard kitchen furniture. The machine uses no

Human cystatins C and D share almost identical primary structures of two out of the three segments proposed to be of importance for enzyme interactions but have markedly different profiles for inhibition of the target cysteine peptidases, cathepsins B, H, L, and S. To investigate if the N-terminal binding regions of the inhibitors are responsible for the different inhibition profiles, and thereby