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This ESMO CPG provides key recommendations and algorithms for managing DLBCL, FL, HL, MCL, MZL, PCNSL and PTCL. •It covers epidemiology, diagnosis, staging, risk assessment, treatment of primary and refractory disease and follow-up. •Treatment algorithms for each lymphoma type are provided. •The author group encompasses a multidisciplinary group of experts from different institutions and countries
Normally, the measurement limit for luminescence analysis of quartz is 50-70 ka with the most widely used single aliquot regeneration (SAR) protocol, consequently, the dating of MIS 3 and MIS 4 samples or older is problematic using quartz. However, recent studies propose that the sensitivity-corrected multiple aliquot regenerative dose (SMAR) measurement technique has the potential to extend the d
The introduction of “water-in-salt” electrolyte (WiSE) concept opens a new horizon to aqueous electrochemistry that is benefited from the formation of a solid-electrolyte interphase (SEI). However, such SEI still faces multiple challenges, including dissolution, mechanical damaging, and incessant reforming, which result in poor cycling stability. Here, we report a polymeric additive, polyacrylamid
Multi-hazard events, though infrequent and rare, are responsible for a substantial portion of global economic losses. This book chapter investigates the complexities of multi-hazard events and explores the design challenges and methodologies in multi-hazard risk assessment and structural resilience for wooden structures. Special attention is given to the interaction between earthquakes, fires, and
Context: AI technologies are increasingly embedded in products and software engineering processes of industrial IoT, autonomous systems, and cyber-physical systems. It is therefore essential to ensure alignment with safety, reliability, and ethical standards. However, practical software engineering methods for managing misalignment risks remain underdeveloped. Objective: This study aims to explore
Rationale: Proper sedation for neonates undergoing uncomfortable procedures may reduce stress and prevent complications. Midazolam is a short-acting benzodiazepine that is used in neonatal intensive care units. This is an update of a Cochrane review first published in 2003. Objectives: To assess the benefits and harms of midazolam – compared with placebo, other pharmacological interventions, and n
As 6G networks evolve, offloading extended reality (XR) applications emerges as a key use case, leveraging reduced latency and edge processing to migrate computationally intensive tasks, such as rendering, from user devices to the network. This enables lower battery consumption and smaller device form factors in cellular environments.However, offloading incurs delays from network transmission and
The objective of this study is to develop a prototype of an electronic system based on computer vision that enhances the level of autonomy in mission execution by a UAV. Unlike a final embedded electronic system, this prototype utilizes the capabilities of a personal computer, allowing for rapid configuration of equipment, algorithm refinement, and program adjustments.The developed system includes
In an interconnected world, climate change impacts can cascade across sectors and regions, creating systemic risks. Here we analyse cascading climate change impacts on the EU, originating from outside the region, and identify critical intervention points for adaptation. Using network analysis, we integrate stakeholder-co-produced impact chains with quantitative data for 102 countries across foreig
The AU Microscopii planetary system is only 24 Myr old, and its geometry may provide clues about the early dynamical history of planetary systems. Here, we present the first measurement of the Rossiter–McLaughlin effect for the warm sub-Neptune AU Mic c, using two transits observed simultaneously with the European Southern Observatory’s (ESO’s) Very Large Telescope (VLT)/Echelle SPectrograph for R
Objective: The aim of this study was to explore experiences and challenges in handling feedback and criticism among early career surgeons. Design: This study is part of a prospective, exploratory, longitudinal study evaluating surgical residents throughout residency. Semi-structured interviews were conducted with medical doctors applying to a locum or residency position in a surgical specialty. An
The modelling of filtered chemical source terms remains a fundamental challenges for large eddy simulation (LES) of reacting flows, such as combustion. This study investigates various scale similarity models for predicting filtered reaction rates. The theoretical foundation of scale similarity models is reviewed, and several extensions and generalisations are proposed. These include the distinctio
This letter addresses loss of packets in a wireless fronthaul link being interpreted as channel errors for the service link. This may occur if, for instance, User Equipment (UE) is served by a radio unit in an Uncrewed Aerial Vehicle (UAV) via a wireless fronthaul link to a baseband unit (BU) on the ground. The fronthaul packet loss leads to a mismatch between the real and estimated channel state,
The rapid growth of smart logistics, driven by IoT devices and data-intensive applications, necessitates secure, scalable, and efficient computing frameworks. As the edge-fog-cloud (EFC) paradigm supports real-time data processing, it faces significant security threats and attacks, including privacy risks, data breaches, and unauthorized access. To address these security threats and attacks, block
Improving lignocellulosic biorefineries is a crucial step in transitioning from a fossil-based economy to a bio-based one. These biorefineries convert lignocellulosic biomass feedstocks into value-added products such as biofuels, biopower, biochemicals, and biomaterials, while also recovering valuable components from underutilized process streams. Pulp and paper mills are lignocellulosic biorefine
This study explores the potential for stormwater reuse to reduce potable water consumption for toilet flushing and laundry. A pilot project utilizing silicon carbide (SiC) membranes in Lund achieved significant reductions in contaminants, with permeate meeting EU standards for non-potable applications.A permanent (SiC) membrane installation in Malmö demonstrated a 38% reduction in potable water us
Transformer models pre-trained on self-supervised tasks and fine-tuned on downstream objectives have achieved remarkable results across a variety of domains. However, fine-tuning these models for clinical predictions from longitudinal medical data, such as electronic health records (EHR), remains challenging due to limited labeled data and the complex, event-driven nature of medical sequences. Whi
pyPFC is a comprehensive open-source Python package for setting up, running and analyzing 3D phase field crystal (PFC) simulations. The object-oriented code is designed to take full advantage of GPU acceleration, but can also be ran on purely CPU-based systems. The overarching ambition with the pyPFC package is to provide an easily accessible and computationally efficient PFC simulation framework,
