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While several scholars do not consider the anointing of (the feet of) Jesus in Bethany described in the Gospel of John to carry any messianic connotations, some claim that a royal messianic notion is behind the anointing. The hypothesis of this paper is that the anointing is indeed to be understood as messianic, but that it is insufficient to consider only one Christological motif to be in the bac
Hypertension is the leading risk factor for premature death worldwide. The identification of modifiable causes of hypertension remains an imperative task. We aimed to investigate associations between 79 proteins implicated in cardiovascular disease and longitudinal blood pressure (BP) changes in three Swedish prospective cohorts. In a discovery phase, we investigated associations between baseline
Fire regimes across the world are expected to be altered by continuing variations in socio-economic conditions and climate. Current global fire-vegetation models are able to represent the present-day fire activity, but it is unclear how well they can simulate past or future scenarios. Here we use sedimentary charcoal-based biomass burning reconstructions to evaluate fire probability and total carb
Much of the income equalization that took place during the first half of the twentieth century was driven by shifts in the shares of the incomes of the rich, such as the top 1 percent. But the available studies using tabulated data have not been wholly able to account for the relative decline in top earners’ incomes. In this paper, we present the first evidence on the composition of the top grou
Aggregated α-synuclein (α-syn) is the main constituent of Lewy bodies, which are a pathological hallmark of Parkinson’s disease (PD). Environmental factors are thought to be potential triggers capable of initiating the aggregation of the otherwise monomeric α-syn. Braak’s seminal work redirected attention to the intestine and recent reports of dysbiosis have highlighted the potential causative rol
Diamond-Blackfan anemia (DBA) is a rare genetic disorder in which patients present a scarcity of erythroid precursors in an otherwise normocellular bone marrow. Most, but not all, patients carry mutations in ribosomal proteins such as RPS19, suggesting that compromised mRNA translation and ribosomal stress are pathogenic mechanisms causing depletion of erythroid precursors. To gain further insight
This study aimed to analyze stressors to which medical staff is vulnerable due to the coronavirus disease 2019 (COVID-19) pandemic. It also imposes a hierarchy on complex relations among stressors for excavating underlying structure and builds a model of interrelationships contrasting reality. The design of this study comprises a literature survey, data collection from primary sources, and analysi
Extending beyond previous research biases towards large cities or analyses based largely on one type of urban agriculture (UA) (such as market gardening, or home gardening), this research aimed to investigate all forms of UA within two intermediate-sized Ghanaian cities (Techiman and Tamale). Where was being farmed? For whom, and why? The paper considers how findings compare to Ghana's larger citi
In ecological sciences, animal diets are often simplified to ‘resources' or ‘caloric quantities'. However, in the present study, we investigated the optimal foraging strategy of Atlantic cod Gadus morhua when both macro- and micro-nutritional requirements are accounted for. Proteins cannot be synthesized from fatty acids, so the proteins for gonad development must come from other dietary sources.
Genomic rearrangements in cancer cells can create gene fusions where the juxtaposition of two different genes leads to the production of chimeric proteins or altered gene expression through promoter-swapping. We have previously shown that fusion transcripts involving microRNA (miRNA) host genes contribute to deregulation of miRNA expression regardless of the protein-coding potential of these trans
Background: Traumatic brain injury (TBI) is a common injury and constitutes up to 3% of emergency department (ED) visits. Current studies show that TBI is most commonly inflicted in older patients after ground-level falls. These patients often take medications affecting coagulation such as anticoagulants or antiplatelet drugs. Guidelines for ED TBI-management assume that anticoagulation therapy (A
INTRODUCTION: Since 2005, disease-related human genetic diversity has been intensively characterized using genome-wide association studies (GWAS). Understanding how and by whom this work was performed may yield valuable insights into the generalizability of GWAS discoveries to global populations and how high-impact genetics research can be equitably sustained in the future.MATERIALS AND METHODS: W
Over the years, technological developments and societal changes have forced companies to modify their organizing practices. Companies operating in the construction sector are no exception, but due to their project-based structure, it is more difficult to coordinate change initiatives. Indeed, the construction sector is often described as conservative and unwilling to adopt change. However, there i
PURPOSE: Children with cerebral palsy (CP) have an increased risk of cognitive difficulties and should be offered cognitive assessments. In Sweden, the CP Cog protocol recommends children with CP undergo cognitive assessments at the start of primary and secondary school. To assess children with CP can be challenging, in particular when children are non-vocal or do not speak the local language. In
Background: Patient safety gained public notoriety following the 1999 report of the Institute of Medicine: To Err is Human – Building a Safer Health System which summarized a culminated decades' worth of research that had so far been largely ignored. The aim of this study was to analyze the report's impact on patient safety research in anesthesiology.Methods: A bibliometric analysis was performed
Nurses’ work-related stress during the Covid-19 pandemicNagel C. Nilsson K. BackgroundDuring the Coronavirus pandemic, healthcare workers and primarily the nurses, were on the frontline. Many nurses have had to face exposure and facing higher risks to their own health. It is known that stress is a factor that can contribute to mental health issues and an increased turnover intention. Objective Thi
Objectives. To discover whether the proteolytic activity of prostate- specific antigen (PSA) affects the structure and function of parathyroid hormone-related protein (PTHrP), as both are abundant components of human seminal plasma. Methods. The ability of PTHrP to act as a substrate was studied by incubating a synthetic polypeptide, consisting of 34 amino acid residues of the amino-terminal domai
Summary: Currently, there is no reproducible, widely accepted gold standard to classify osteoporotic vertebral body fractures (OVFs). The purpose of this study is to refine a method with clear rules to classify OVFs for machine learning purposes. The method was found to have moderate interobserver agreement that improved with training. Introduction: The current methods to classify osteoporotic ver
PURPOSE: Water saturation shift referencing (WASSR) Z-spectra are used commonly for field referencing in chemical exchange saturation transfer (CEST) MRI. However, their analysis using least-squares (LS) Lorentzian fitting is time-consuming and prone to errors because of the unavoidable noise in vivo. A deep learning-based single Lorentzian Fitting Network (sLoFNet) is proposed to overcome these s
Treatment of chronic osteomyelitis by radical debridement and filling of the dead space with antibiotic containing calcium sulphate/hydroxyapatite (CaS/HA) bone substitute has shown excellent long-term outcomes. However, in extensive infections, sessile bacteria may remain in bone cells or soft tissues protected by biofilm leading to recurrences. The primary aim of this study was to evaluate if sy
