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Recent work has uncovered a role of the microRNA (miRNA) miR-29 in remodeling of the extracellular matrix. Partial bladder outlet obstruction is a prevalent condition in older men with prostate enlargement that leads to matrix synthesis in the lower urinary tract and increases bladder stiffness. Here we tested the hypothesis that miR-29 is repressed in the bladder in outlet obstruction and that th

BACKGROUND: Arsenic in drinking water causes severe health effects. Indigenous people in the South American Andes have likely lived with arsenic-contaminated drinking water for thousands of years. Inhabitants of San Antonio de los Cobres (SAC) in the Argentinean highlands generally carry an AS3MT (the major arsenic-metabolizing gene) haplotype associated with reduced health risks due to rapid arse

In this paper, we show how studies of fracture mineral paragenesis, their orientation and Ar-40/Ar-39 geochronology can be applied in order to recognise the brittle tectonothermal evolution in an area. Samples were selected from nearly 18 km of drill cores from the upper I km of the Fennoscandian Shield obtained during the site investigation for a repository of spent nuclear fuel in Forsmark, cent

Disperse dyes are common sensitizers among textile dyes. Contact allergy to disperse dyes has been documented in studies carried out in southern Europe, however, corresponding studies have not been performed in the Scandinavian countries. The aim of this study was thus to evaluate the prevalence of allergic reactions to a mix of textile dyes consisting of 8 disperse dyes: Disperse (D) Blue 35, 10

Popular Abstract in Swedish Under de senaste årtiondena har prestandan i elektriska kretsar växt i en rasande takt. Detta har lett till otaliga innovationer som har förbättrat samhället. Grunden till denna utveckling grundar sig i två uppfinningar: transistorn och den integrerade kresten. Till skillnad från många andra grundläggande elektroniska komponenter har en transistor tre elektroder. En eRecent decades have seen an exponential increase in the functionality of electronic circuits, allowing for continuous innovation, which benefits society. This increase in functionality has been facilitated by scaling down the dimensions of the most important electronic component in modern electronics: the Si-based MOSFET. By reducing the size of the device, more transistors per chip area is possib

The aim of this article is to offer an object lesson in how historians could make use of feature film as primary source material if they were to use the analytical tools developed in the field of film studies and by historians who started to work with film in the 1970s and 1980s. My own work on representations of maidservants in Swedish feature films in the 1930s and 1940s is used as a case in poi

Background: Prostate cancer patients have an increased risk of fractures as a consequence of skeletal metastases and osteoporosis induced by endocrine treatment. Data on incidence of fractures and risks in subgroups of men with prostate cancer are sparse. Our aim with this study is to report the risk of fractures among men with prostate cancer in a nationwide population-based study. Patients and m

Background: Regional myocardial function is typically evaluated by visual assessment by experienced users, or by methods requiring substantial post processing time. Visual assessment is subjective and not quantitative. Therefore, the purpose of this study is to develop and validate a simple method to derive quantitative measures of regional wall function from velocity encoded Cardiovascular Magnet

BACKGROUND: The aim of the current study was to investigate the possibility of increasing the maximal tolerated dose (MTD) of a tumor-selective radiolabeled antibody when radioimmunotherapy (RIT) is combined with extracorporeal depletion of radioimmunoconjugates from the circulation. Furthermore, the authors evaluated whether this increase in dose improved the therapeutic effect on solid manifest

Malarial infection is associated with complex immune and erythropoietic responses in the host. A quantitative understanding of these processes is essential to help inform malaria therapy and for the design of effective vaccines. In this study, we use a statistical model-fitting approach to investigate the immune and erythropoietic responses in Plasmodium chabaudi infections of mice. Three mouse ph

Background: High plasma copeptin (copeptin), the C-terminal fragment of arginine vasopressin pro-hormone, has been associated with the metabolic syndrome (MetS), diabetes mellitus (DM) development and nephropathy. Here we tested whether elevated copeptin level is associated with later development of the MetS, its individual components and microalbuminuria. Methods: We analysed copeptin at baselin

Aims/hypothesis Latent autoimmune diabetes in adults (LADA) is phenotypically a hybrid of type 1 and type 2 diabetes. Genetically LADA is poorly characterised but does share genetic predisposition with type 1 diabetes. We aimed to improve the genetic characterisation of LADA and hypothesised that type 2 diabetes-associated gene variants also predispose to LADA, and that the associations would be s

Magnetotactic bacteria (MTB) are known to biosynthesise single-domain magnetite (Fe3O4) for geomagnetic navigation and their relict magnetosomes (called magnetofossils) can control the magnetic properties of lake and marine sediments. Magnetotactic bacteria also produce greigite (Fe3S4) magnetosomes but, compared to those made of magnetite, relatively little is known about the sedimentary environm

Hydrothermal alteration resulting in albitization and quartz dissolution has been identified in Paleoproterozoic metagranites down to - 1000 m elevation at Forsmark, Sweden. The alteration features were discovered during investigations to locate a site for the disposal of spent nuclear fuel in a deep geological repository. In general, albitization occurs extensively, but it is also observed locall

Objective: Development of biomarkers for early detection of Alzheimer's disease (AD) is a major clinical research goal. On the basis of the hypothesis that cardiovascular risk factors contribute to the pathogenesis of AD, we investigated whether the cardiovascular risk markers midregional proadrenomedullin (MR-proADM) and midregional proatrial natriuretic peptide (MR-proANP) predict a major clinic

Introduction: Risedronate, a bisphosphonate for treatment and prevention of osteoporosis, has been shown in several clinical trials to reduce the risk of fractures in postmenopausal women with osteoporosis. The cost-effectiveness of risedronate treatment has previously been evaluated within different country settings using different model and analysis approaches. The objective of this study was to

In this paper a study of a career planning project launched by the Swedish National Tax Board is reported. The project, named Propeller, was initiated in 1998 as a joint endeavour among three agencies: the Swedish National Tax Board, the Regional Stockholm Tax Office and the Enforcement Authority. The intention was to create a common micro labour market in order to encourage employees to become mo

Popular Abstract in Swedish Köpenhamnsevangeliariet skrevs och illuminerades i England omkring år 1000, och intar en viktig position i konsthistorien genom sina ikonografiska likheter med det 300 år äldre Lindisfarneevangeliariet. I föreliggande avhandling behandlas handskriften i sin helhet med avseende på dess framställning och senare historia, men den huvudsakliga analysen rör bildernas stilistThe subject of this thesis is the Copenhagen Gospel Book , written and illuminated in England c 970 with additions from c 1020. The thesis is divided into three main parts focusing on different aspects of the manuscript. The first part deals with problems concerning provenance, palæography, later additions and the physical architecture of the manuscript. The author questions the opinion that the m

OBJECTIVES: Sleep deprivation has experimentally been shown to adversely influence glucose metabolism, endocrine function and sympathovagal balance in young men without known serious disease. We investigated the impact of sleep problems and resting heart rate in a large sample of self-reported, healthy middle-aged men and women on long-term mortality. METHODS: In all 22,444 men and 10,902 women pa

Popular AbstractAvhandlingen är en feministisk analys av regionalpolitiken som möjliggörare för kvinnor som vill försörja sig på landbygden som egna företagare. Fokus i studien är kvinnor som ville men inte ansåg sig ha eller fick möjlighet driva sina företagsidéer vidare och därför avvecklade dem på ett tidigt stadium. I intervjuer redogör ett antal kvinnor för sina upplevelser av att arbeta för This thesis deals with questions concerning the different strategies women adopt in order to support themselves when they become unemployed in rural areas. One strategy is to start a business of one's one, a strategy supported and called for by the Swedish Government, especially during the 1990s economic recession. Another important factor was the Swedish membership in the EU that demanded cutback