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Aim: The Cockcroft-Gault (CG) creatinine-based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous over- or underdosing. Methods: In a cross-sectional analysis, CG was validated against measured GFR (mGFR) in 14 804 participants and compared with the Modification-of-Diet-in-Renal-Diseases (MDRD), Chronic-Kidney-Disea

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Negative health effects of exposure to particles of outdoor origin have been confirmed by epidemiological studies. In developed countries, we spend on average 65% of our time in our homes. Thus, the properties of airborne particles indoors need to be understood. The aim of this PhD thesis was to investigate the differences in physicochemical and toxicological characteristics of fine particles (PM2.5

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Summariskt kan skiljeförfarandet beskrivas syfta till ett snabbt och slutligt avgörande av tvister utan insyn från utomstående. Med denna bakgrund är det av stor vikt för de involverade parterna att tvistelösningen inte efterföljs av en långdragen och offentlig process i allmän domstol. I svensk rätt finns därav ingen möjlighet att överklaga ett skiljeförfarande. Detta sätter stora krav på att skiCommercial arbitration can briefly be described as being designed to offer a quick and final conclusion to disputes without transparency for the public. With this in mind, it is of great importance that the verdict isn’t followed by long and public proceedings in court. Thus, the Swedish regulation doesn’t allow the losing party to appeal against the arbitrators’ verdict. This puts a heavy burden

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Title: The relevance of knowledge transfer - A qualitative study of labour-intensive organisations with high employee turnover Seminar date: 2015-06-05 Course: FEKH19, Degree Project in Strategic Management, Undergraduate Level, 15 ECTS Authors: Elina Jonsson, Hanna Sjöstrand, Linnette Ericsson Advisor: Anna Brattström Key Words: Knowledge transfer, Labour-intensive organisations, Employee turnove

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We characterised patients with mantle cell lymphoma (MCL) with poor prognosis based on differences in immune infiltration. Different expressions of the tumour cell markers Cyclin D1 and sex-determining region Y-box transcription factor 11 (SOX11), and the immune markers cluster of differentiation 3 (CD3), CD4, CD8, CD25, forkhead box protein P3 (FoxP3), T-box transcription factor TBX21 (T-bet), pr

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Background and purpose — Many countries implemented strict lockdown policies to control the COVID-19 pandemic during March 2020. The impacts of lockdown policies on joint surgeries are unknown. Therefore, we assessed the effects of COVID-19 pandemic lockdown restrictions on the number of emergency and elective hip joint surgeries, and explored whether these procedures are more/less affected by loc

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Flood risk is a complex and transboundary issue that is expected to escalate with climate change and requires to be governed by collaborative networks of actors. Municipal administrations have been suggested to have a particularly important and challenging role in such governance. Although collaborative governance has attracted intense scientific attention, empirical studies generally focus either

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Background: Infertility affects 15%–25% of all couples during their reproductive life span. It is a significant societal and public health problem with potential psychological, social, and economic consequences. Furthermore, infertility has been linked to adverse long-term health outcomes. Despite the advanced diagnostic and therapeutic techniques available, approximately 30% of infertile couples

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BACKGROUND: Radiostereometric analysis (RSA) is a highly accurate tool to detect implant migration and predict loosening following total knee arthroplasty (TKA). However, little is known about the predisposing risk factors for implant migration, nor which migration profile should be considered physiological (i.e., merely part of an implant-settling phase) and which should be considered pathologica

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Background: Palliative care focuses on identifying, from a holistic perspective, the needs of those experiencing problems associated with life-threatening illnesses. As older people approach the end of their lives, they can experience a complex series of problems that health-care professionals must identify and document in their patients’ records. Documentation is thus important for ensuring high-

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Background: Dominant and recessive autosomal pathogenic variants in the three major genes (COL6A1-A2-A3) encoding the extracellular matrix protein collagen VI underlie a group of myopathies ranging from early-onset severe conditions (Ullrich congenital muscular dystrophy) to milder forms maintaining independent ambulation (Bethlem myopathy). Diagnosis is based on the combination of clinical presen

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Denna uppsats undersöker gränserna för ansvarsfriheten vid våld utövat i nödvärn enligt svensk rätt och granskar de rättspolitiska överväganden som ligger till grund för gränsdragningarna i lag och praxis. Framställningen är avgränsad till angrepp mot person och behandlar inte straffmätningen vid överskriden nödvärnsrätt. En grundläggande förutsättning för ansvarsfrihet är att rätt till nödvärn fThis paper examines the Swedish law relating to the limits of violence applied when exercising self-defence and explores the prescriptive considerations underlying law and practice. The exposition is delimited to assaults against individuals and does not cover questions regarding leniency of punishment. A basic condition for freedom of responsibility is the existence of a right of self-defence. S

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Genom en större lagreform, från år 2004, infördes nya bestämmelser i 6 kap., bland annat i syfte att förstärka skyddet för barn mot sexuella övergrepp. En av dessa var bestämmelsen om våldtäkt mot barn som bland annat kriminaliserar samlag eller med samlag jämförlig handling med barn under femton år. En lindrigare form av våldtäkt mot barn, sexuellt utnyttjande av barn, infördes med samma reform. In 2004, reforms were made in chapter 6 of the Penal Code in regards to strengthen the protection for children against sexual assaults. One of these was the provision regarding child rape that outlaws intercourse or comparable actions to intercourse with children under the age of fifteen. A minor form of child rape, sexual use of children, was implemented with the same reform. This was intended to

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Title: The perceived innovativeness of the manufacturing process and perceived product quality. The case of creative and technology-intensive industries. Course: BUSN39 Degree Project in Global Marketing Authors: Federica Piccone & Joanna Pilawa Supervisor: Javier Cenamor Keywords: manufacturing process; perceived innovativeness; perceived quality Thesis Purpose: The main purpose is to

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Filmdistributionen befinner sig i en ny digital verklighet. Den snabba tekniska utveckling som har ägt rum de senaste decennierna har inneburit stora utmaningar för såväl filmindustrins affärsmodell som de upphovsrättsliga bestämmelser som reglerar skyddet för filmverk och dess upphovsmän. Ett exempel på en bestämmelse vars tillämpningsområde är oklart till följd av den nya distributionen av digitFilm distribution has found itself in a new digital reality. The swift progress of technology that has taken place during the past decades has posed major challenges for both the film industry's business model and for the copyright laws that regulate the area. An example of a regulation whose scope is unclear as a result of the new distribution of digital copies is the principle of exhaustion.

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Skiljeförfarandet utgör det enda alternativ till domstolsförfarande som också resulterar i en exigibel dom med rättskraft. Ett avtal om skiljeförfarande utgör ett hinder mot domstolsprövning om det åberopas inför domstol. Motsvarande prövningshinder gäller för skiljenämnd om en tvistefråga som anhängiggörs skiljenämnden faller utanför skiljeavtalets tillämpningsområde, eftersom skiljenämnden då inArbitration constitutes the only alternative to a judicial proceeding in court that also results in a legally binding judgement. An arbitration agreement also constitutes a procedural impediment if reference to it is made before the court. Corresponding procedural hindrance applies to an arbitration tribunal or to an arbitrator if the matter of dispute referred to arbitration lies outside the scop

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Lithium ion batteries enable the implementation of renewable energy and electric vehicles, both of which are crucial for the transition to a sustainable society. Due to environmental, economic and political reasons, these batteries must be recycled efficiently. Most lithium ion batteries are placed on the market in electric vehicles, which are reaching end-of-life at an exponential pace, prompting

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Lagen om hemlig dataavläsning trädde i kraft den 1 april 2020. Lagen innebär att brottsbekämpande myndigheter, utöver säkerhetspolisen, kan få tillgång till innehållet i den enskildes mobiltelefon och dator. Särskilt vid tvångsmedelslagstiftning är det viktigt att lagstiftaren förhåller sig till de rättsliga principer och begrepp som gäller på ett korrekt vis. Denna uppsats ämnar att kritiskt graThe Secret data interception law was implemented on 1 of April, 2020. The law allows law enforcement authorities, not just the security police, to gain access to information from an individuals' mobile phone and computer. In the case of coercive measures legislation, it is important that the legislator relates to the corresponding legal principles and concepts in a correct way. This essay in

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I syfte att åstadkomma den gemensamma inre marknaden, har EU-domstolen fastslagit att medlemsstaterna vid utövandet av sin lagstiftningsbehörighet gällande direkt beskattning måste iaktta unionsrätten. Inom unionsrätten finns etableringsfriheten, vilken kräver att etableringar inte får missgynnas beroende på var inom unionen etablering genomförs. Som huvudregel har det, i de nationella skattesysteIn most national tax legislations within EU, only groups of companies within the same Member State are allowed to consolidate their gains and losses within the group, which clearly treats foreign establishments unfairly and therefore disregards the freedom of establishment. After the Marks & Spencer case, it’s been clear that national tax law that only allows group relief between national comp

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The removal of snow and ice from aircraft prior to take-off is a major task at all airports located in cold climates. Currently the removal of ice and snow is carried out using large amounts of costly and environmentally harmful glycol that is sprayed onto the outer surface of the aircraft. Tougher environmental regulations and a cost conscious market have created a growing need for alternative me