Sökresultat

Over the last years an expanding family of small RNAs (i.e. microRNAs, siRNAs and piRNAs) was recognized as key players in diverse forms of gene silencing and chromatin organization. Effectors functions of these small RNAs are achieved through ribonucleoprotein (RNP) complexes containing at their center an Argonaute/Piwi protein. Although these proteins and their small RNA-associated machinery can

Estimating the change in groundwater recharge from an introduced artificial recharge system is important in order to evaluate future water availability. This paper presents an inverse modeling approach to quantify the recharge contribution from both an ephemeral river channel and an introduced artificial recharge system based on floodwater spreading in arid Iran. The study used the MODFLOW-2000 to

In this study, we investigate which factors affect the false positive fraction (FPF) for digital breast tomosynthesis (DBT) compared to digital mammography (DM) in a screening population by using classification and regression trees (C&RT) and binary marginal generalized linear models. The data was obtained from the Malmö Breast Tomosynthesis Screening Trial, which aimed to compare the performa

This paper reports a method to produce a solvent-free extract from green tea leaves with high content of catechins and low content of caffeine, in two steps and using only "green" solvents. The method is based on the pressurized liquid extraction (PLE) of the green tea leaves using ethyl lactate as solvent, followed by a selective precipitation procedure using the supercritical carbon dioxide (SCC

Acute treatment with 17β-estradiol provides effective neuroprotection during the first days after acute brain injury, however, effects of chronic activation of estrogen receptor beta (ERβ) on recovery of function after experimental stroke have not been investigated. The present study, therefore, was conducted to test if delayed treatment with the specific ERβ ligand 4-(1-phenyl-cyclohexyl)-phenol

Neighborhood characteristics have been associated with both depression and diabetes, but to date little attention has been paid to whether the association between depression and diabetes varies across different types of neighborhoods. This prospective study examined the relationship between depression, neighborhood deprivation, and risk of type 2 diabetes among 336,340 adults from a national-repre

Background: Ratios of values of brachytherapy source strengths, as measured by hospitals and vendors, comprise constant differences as, e.g., systematic errors in ion chamber calibration factors and measurement setup. Such ratios therefore have the potential to reveal the systematic changes in routines or calibration services at either the hospital or the vendor laboratory, which could otherwise b

This study addresses development of a content-valid cross-Nordic version of the Housing Enabler and investigation of its inter-rater reliability when used in occupational therapy rating situations, involving occupational therapists, clients, and their home environments. The instrument was translated from the original Swedish version of the Housing Enabler, and adapted according to accessibility no

Popular Abstract in Swedish Introduktion I Sverige dör i genomsnitt 4 personer i självmord dagligen vilket gör detta till en av de absolut vanligaste dödsorsakerna bland unga människor. Varje självmord föregås av ofattbart mänskligt lidande och innebär en tragedi för de anhöriga. Antalet självmordsförsök som kommer till vårdens kännedom är cirka 9000 varje år, men det finns ett stort mörkertal. BaRisk assessment of suicidal behaviour is one of the most important tasks in clinical psychiatry and a major determinant of subsequent care and treatment selections. To date, suicide risk assessment is based solely on clinical evaluations, which inevitably leads to subjective interpretations and decisions by the psychiatrist. In order to find more robust instruments in the evaluation of suicidality

Work in rodents has demonstrated that progenitor transplantation can achieve limited photoreceptor replacement in the mammalian retina; however, replication of these findings on a clinically relevant scale requires a large animal model. To evaluate the ability of porcine retinal progenitor cells to survival as allografts and integrate into the host retinal architecture, we isolated donor cells fro

The global socially engaged Buddhist movement emphasis Buddhism’s engagement with society. It is a socially and politically active form of Buddhism that came into being in the twentieth century. Engaged Buddhism is a non-centralized movement that emerged in response to multiple crises in modern Asia. It has been described as a modern form of Buddhism, influenced by; modern, social, economic, psych

We report on the disruption of DNA gels cross-linked with ethylene glycol diglycidyl ether (EGDE), by sunlight exposure. The disruption over exposure time was characterized through the cumulative DNA release, the evolution in dry weight and extent of swelling, and also rheologically. The network disruption is shown to depend strongly on the degree of cross-linking density. Bovine serum albumin has

The use of nonstandardized and inadequately validated outcome measures in atopic eczema trials is a major obstacle to practising evidence-based dermatology. The Harmonising Outcome Measures for Eczema (HOME) initiative is an international multiprofessional group dedicated to atopic eczema outcomes research. In June 2011, the HOME initiative conducted a consensus study involving 43 individuals from

Context: Our aim was to present a summary of the Second International Consultation on Bladder Cancer recommendations on the diagnosis and treatment options for non-muscle-invasive urothelial cancer of the bladder (NMIBC) using an evidence-based approach. Objective: To critically review the recent data on the management of NMIBC to arrive at a general consensus. Evidence acquisition: A detailed Med

In the present study, the electrocatalytic oxidation of reduced beta nicotinamide adenine dinucleotide (NADH) was investigated using a pencil graphite electrode modified with quercetin (PGE/QH(2)). The PGE/QH(2) was prepared through two steps: (i) the pre-treatment of PGE at 1.40V vs. Ag vertical bar AgCl vertical bar KCl(sat.) in pH 7.0 phosphate buffer containing 0.1 M KCl for 60 s and (ii) adso

Context: Magnetic resonance imaging (MRI) combined with magnetic resonance spectroscopy imaging (MRSI), dynamic contrast-enhanced MRI, and diffusion-weighted MRI emerged as promising tests in the diagnosis of prostate cancer, and they show encouraging results. Objective: This review emphasizes different functional MRI techniques in the diagnosis of prostate cancer and includes information about th

For ionic surfactants in general, a change from simple to polymeric counterions leads to increasing attraction between micelles, condensing them in a concentrated phase. In the present study, two novel “complex salts” were prepared in which the cationic surfactant hexadecyltrimethylammonium was neutralized by two different copolyions, both having poly(methacrylate) main chains randomly decorated w

Phenological models have mainly been developed to capture the seasonal development of individual trees and local populations, using data from meteorological stations. Ecosystem models that incorporate phenology are however commonly driven by gridded climate data. Using two phenological models to simulate budburst of birch in Germany, we assessed how combining phenological point observations with g

Background: The aim was to study health-related quality of life, five years after an intervention study among young adults with asthma. Method: The design was a follow-up study of a cohort of young adults with asthma (n = 64) and 248 general, population controls. Both groups were investigated at follow-up with a respiratory questionnaire and one generic quality-of-life instrument, and the asthma c