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This account describes our efforts toward developing a stereodivergent entry to perophoramidine and the communesin alkaloids. The original approach toward our simplified model substrates relied on a palladium-catalyzed carbopalladation–carbonylation of a tetrasubstituted olefin to install the vicinal all-carbon quaternary stereocenters present in the target molecules, the olefin's stereochemistry
The international prognostic index (IPI) and similar models form the cornerstone of clinical assessment in newly diagnosed diffuse large B-cell lymphoma (DLBCL). While being simple and convenient to use, their inadequate use of the available clinical data is a major weakness. In this study, we compared performance of the International Prognostic Index (IPI) and its variations (R-IPI and NCCN-IPI)
Background: Standard treatment of localized squamous cell carcinoma of the anus (SCCA) is radiotherapy (RT) combined with chemotherapy, that is, chemoradiation (CRT). Primary surgery has a limited role, but is a recommended treatment for small well differentiated SCCA localized in the anal margin, with re-excision or postoperative RT/CRT in case of involved surgical margins. The evidence supportin
Context Emerging evidence has related the gut microbiome and circulating metabolites to human obesity. Gut microbiota is responsible for several metabolic functions, and altered plasma metabolome might reflect differences in the gut microbiome. Objective To identify a plasma metabolite profile associated with body mass index (BMI) in a general population and investigate whether such metabolite pro
This study evaluated the psychometric properties of the Swedish version of the Behavior Rating Inventory of Executive Function – Second Edition (BRIEF2) across self-, parent-, and teacher-report forms in a gender- and age-balanced community sample of Swedish youth. We examined factor structure, internal consistency, inter-rater reliability, measurement invariance, and age- and gender-related diffe
Objective: Although rare, malignant ovarian germ cell tumors (MOGCTs) account for 70 % of ovarian malignancies in women younger than 30 years. Given the rarity of MOGCTs and the limited population-based data, this study aims to examine national treatment patterns and survival in women with MOGCTs, with a focus on fertility-sparing surgery. Methods: This nationwide population-based study included a
Toxins are naturally poisonous small compounds, peptides and proteins that are produced in all three kingdoms of life. Venoms are animal toxins and can contain even hundreds of different compounds. Numerous approaches have been used to detect toxins, including prediction methods. We developed a novel machine learning-based predictor for detecting protein toxins from their sequences. The gradient b
Agriculture 4.0, the 4th agricultural revolution, aims to adopt digital technologies to make farming more planned, predictive, and productive. The emergence of innovative ecosystems with increased relevance in implementation, integration, and connectivity is evident nowadays. The influence of all these technical innovations on our daily lives is immense. From a technical perspective, this leads us
Phylogenetic relationships of the predominantly Andean species-rich nymphalid genus Perisama are explored based on five genetic markers and a total of 3719 bps, and morphological characters of the adults with an emphasis on male genitalia and wing colour patterns. Its monophyly is recovered by including the genera Orophila, which turns out polyphyletic, and Mesotaenia. Two main, highly supported c
The present study aims to explore in what ways teachers at upper secondary level work in a diverse classroom with particular focus on the students’ heterogeneous knowledge of the English language. This heterogeneity, the participants experience, is primarily caused by the discrepancy between those students who use English to a great extent outside the classroom through, for example, frequently pla
Following a macroeconomic stabilization and consistent economicgrowth during the 2000s, Brazil experienced a continuous decrease on povertyincidence for the first time in its contemporary history. While the literatureemphasizes the importance of economic growth alongside social developmentto fight poverty, the Brazilian experience also displays strong governmentaction through expanding social cove
Water sources near mining regions are often susceptible to contamination from toxic elements. This study employs machine learning (ML) techniques to evaluate drinking water quality and identify pollution sources near a chromite mine in Iran. Human health risks were assessed using both deterministic and probabilistic approaches. Findings revealed that concentrations of calcium (Ca), chromium (Cr),
Graphene presents unique optoelectronic properties, making it attractive for the development of a wide range of new and advanced technological applications such as high-speed photodetectors and all-optical modulators. The study and control of the generated carriers in graphene, namely their ultrafast relaxation dynamics, are of great importance for these applications. Here, we report the ultrafast
INTRODUCTION: We examined the relations of misfolded alpha synuclein (α-synuclein) with Alzheimer's disease (AD) biomarkers in two large independent cohorts. METHODS: We included Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably Two (BioFINDER-2) and Alzheimer's Disease Neuroimaging Initiative (ADNI) participants (n = 2315, cognitively unimpaired, mild cognitive impairment,
HPLC-PDA-MS/MS analysis of Syzygium jambos leaf extract allowed the identification of 17 secondary metabolites, including flavonol glycosides, flavonol di-glycosides, and flavones as well as ellagitannins and phenolic acids. The extract showed promising antioxidant activities in different experimental models. In Caenorhabditis elegans, the extract mediated a dose dependent survival rate and decrea
AI-enabled technologies are developing rapidly, but the first wave of the Digit Employers’ Digital Practices at Work Survey (2021-22) showed that their use by firms is not yet widespread. This Data Commentary presents findings from the second wave of the Survey, conducted during 2023, based on responses from 1,150 firms.The findings show that adoption of AI-enabled technologies by UK firms remains
BACKGROUND: Upper gastrointestinal bleeding (UGIB) is a common and potentially fatal medical emergency. This study aimed to investigate the frequency, causes, outcomes, and efficacy of endoscopy in the treatment of UGIB at King Fahad Central Hospital in Jazan, Saudi Arabia.METHODS: Between January 2017 and December 2023, a retrospective study was performed including all hospitalized patients with
This paper investigates whether executive boards consider firm-specific inefficiencies when they change CEOs in the Swedish electricity distribution sector. Firm-level inefficiencies are calculated using data from all Swedish electricity distributors from 2001 to 2022 and a data envelopment analysis (DEA) approach. DEA has advantages over standard financial key performance indicators since it cont
The minimal SO(10) grand unified theory, augmented by higher-dimensional operators, is based on the following Higgs representations: adjoint 45H, spinor 16H, and complex vector 10H. It was recently realized that, as opposed to the conventional wisdom, any intermediate mass scale has to lie close to the grand unification one. This bears profound consequences for the scalar particles mass spectrum a
Introduction Simulation-based studies indicate that crisis checklist use improves management of patients with critical conditions in the emergency department (ED). An interview-based study suggests that use of an emergency manual (EM) - a collection of crisis checklists - improves management of clinical perioperative crises. There is a need for in-depth prospective studies of EM use during clinica
