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Purpose. Radiation enteritis is the main acute side-effect during pelvic irradiation. The aim of this study was to quantify the dose-volume relationship between irradiated bowel volumes and acute enteritis during combined chemoradiotherapy for rectal cancer. Material and methods. Twenty-eight patients with locally advanced rectal cancer received chemoradiotherapy. The radiation therapy was given w
The effect of irradiation on S-phase duration (Ts), labelling index (LI), potential doubling time (Tpot), and cell cycle phase distributions was determined by DNA flow cytometry in xenografted human squamous cell carcinoma of the head and neck (SCCHN). Tumours were treated with a single dose of 3 Gy, and excised at intervals over a 90-h period. Six hours before each excision the tumours were label
BACKGROUND AND PURPOSE: Although the incidence of and mortality from myocardial infarction (MI) have declined in most industrialized countries, incidence studies of stroke have shown less consistent trends. This study examines time trends in the incidence of stroke and case fatality rates in relation to socioeconomic circumstances and history of MI.METHODS: Stroke incidence in the city of Malmö, S
Surface exposed cysteines were genetically engineered in the structure of recombinant horseradish peroxidase (rHRP). Recombinant forms of HRP with either a His-tag or a Strep-tag at the C-terminus were produced, which additionally had cysteines at positions 57, 189 or 309 (C-terminus) of the polypeptide chain. An E coli expression system was exploited. The effect of these mutations on the direct e
BACKGROUND: Immunohistochemical staining for tumor-associated proteins is widely used for the identification of novel prognostic markers. Recently, a tissue-conserving, high-throughput technique, tissue microarray, has been introduced. This technique uses 0.6-mm tissue core biopsy specimens, 500 to 1000 of which are brought into a new paraffin array block, which can be sectioned up to 100 times. M
The prescribing of selective serotonin reuptake inhibitors for adolescents is extensive despite the fact that there are few pharmacokinetic (PK), efficacy, safety, or tolerability studies on this group. This study reports the PK findings from two trials in adolescents treated with citalopram (CIT) in naturalistic clinical settings: one retrospective and one prospective. The aim of our study was to
Objectives. To compare perinatal and infant mortality in breech and cephalic presentations and between planned vaginal and cesarean section (CS) breech deliveries in Sweden. Methods. The study comprised two parts. Study A is a national cohort study for the period 1991-2001, including 22 549 breech presentations and 875 249 cephalic presentations born at >= 38 completed weeks. Study B is a case-con
Context: SHBG regulates free sex steroid levels, which in turn regulate skeletal homeostasis. Twin studies have demonstrated that genetic factors largely account for interindividual variation in SHBG levels. Glucuronidated androgen metabolites have been proposed as markers of androgenic activity. Objective: Our objective was to investigate whether polymorphisms in the SHBG gene promoter [(TAAAA)(n
Background and Purpose - Regular endurance exercise has been shown to reduce the age-related increase in arterial stiffness that is thought to contribute to cardiovascular risk. The aim of this study was to evaluate the influence of age and habitual physical activity on carotid artery wall thickness and stiffness in a population of young to middle-age subjects at low cardiovascular risk. Methods -
Background: The 39 item Parkinson's disease questionnaire (PDQ-39) is the most widely used patient reported rating scale in Parkinson's disease. However, several fundamental measurement assumptions necessary for confident use and interpretation of the eight PDQ-39 scales have not been fully addressed. Methods: Postal survey PDQ-39 data from 202 people with Parkinson's disease (54% men; mean age 70
The aim of the present study was to examine the effects of wearing a light-weight ice-vest (1 kg, water) on physiological and subjective responses in fire fighter’s work. The experiments were carried out in a climatic chamber, in a container under extreme radiant heat, and during simulated smoke-diving. In addition, the physical cooling effect of the ice-vest was measured with a thermal mannequin.
Popular Abstract in Swedish Studien handlar om en konflikt kring en muslimsk friskola i Jönköping. Utifrån fältarbete på den muslimska friskolan och en ordinarie grundskola i kommunen, femton intervjuer och ett omfattande tidningsmaterial har jag problematiserat relationen mellan olika grupper i samhället och vem som har tolkningsföreträde i frågor om skola, fostran och värderingar. De muslimska fThe study is about a conflict concerning a Muslim Independent School in Jönköping. Based on fieldwork carried out on the Muslim Independent School and one of the local authority´s comprehensive schools - which included fifteen interviews and a comprehensive collection of newspaper articles and reports - I have problemised the relationship between the different groups in the local community and who
Popular Abstract in Swedish Syftet är att utifrån studenters livsberättelser, få kunskap om och förståelse för hur de upplever och hanterar sjuksköterskeutbildningens olika delar med särskilt fokus på spänningsfälten mellan: yrkesexamen ? akademisk examen, högskoleförlagd utbildning ? verksamhetsförlagd utbildning samt huvudämnet omvårdnad ? stödämnet medicinsk vetenskap. Syftet är vidare att få kThe aim of this study is to gain knowledge and understanding of how nursing students experience and manage the different parts of the education. A particular focus is set on the tension between a professional degree and an academic degree, between theoretical and clinical studies, and between the subjects nursing and medical science. Furthermore, the aim is to gain knowledge and understanding of a
This thesis is about understandings of understanding and has developed from previous research on study skill and conceptions of learning among participants in various forms of education. The purpose was to investigate understandings of understanding as a phenomenon and the significance of understanding of understanding for learning. The investigation involved 101 persons between 12 and 75 years of
Popular Abstract in Swedish Det har varit långt ifrån självklart att kvinnor ska få ägna sig åt högre studier. För hundra år sedan kom t ex medicinska undersökningar som ”visade” att kvinnor som studerade riskerade att bli sterila. I denna bok undersöker Lina Carls hur kvinnors högre studier 1930-1970 beskrivits i samhällsdebatten och i de lokala diskussionerna vid universiteten i Lund och UppsalaThis dissertation’s overall purpose has been to achieve an increased understanding of why women’s integration into universities has progressed so slowly. Through the analysis of the debates on women in higher education I have wanted to see if the main figures reproduce or contradict the discourse. I have had the aim of not only to show how the genus discourse was possibly repeated but also how in
Popular Abstract in Swedish HIV-2 isolerades första gången 1986, fem år efter att de första fallen av AIDS (orsakade av HIV-1) hade upptäckts i USA. Undersökningar har visat att HIV-2-infekterade individer också kan utveckla AIDS på samma sätt som HIV-1-infekterade personer, men smittsamheten är lägre och inkubationstiden från smitta till symtom förefaller vara längre för HIV-2 jämfört med HIV-1. We have followed a cohort of police officers in Guinea-Bissau between 1990 and 1997 for the study of clinical, immunological and epidemiological aspects of HIV-2 infection. Initially the prevalence of HIV-2 was high (11.6 %) and HIV-1 infection was rare (0.4 %), but over the study period the prevalence of HIV-1 increased significantly whereas the incidence of HIV-1 was relatively stable. For HIV-2
After centuries of feudalism, the establishment of the Japanese parliament (the Diet) in 1890 marked a major turning point in Japanese history. Before 1890, politics as a subject of discussion was confined, more or less, to peer groups in Japanese society. In addition, at certain periods, movements promoting the spread of ideas were strictly controlled or even prohibited. Then came the new Diet,
Colonization consists of two parts, a dispersal phase followed by establishment and reproduction at a new site. Dispersal behaviour influences survival and the access to resources and mates of individuals and is thus closely linked to an organism's fitness. The dispersal ability of two collembolan species, Protaphorura armata and Folsomia fimentaria, was determined in a laboratory experiment. The
Popular Abstract in Swedish Inledning För att kunna sätta in resurser där de behövs bäst, finns det en önskan att kunna förutsäga vilka graviditeter som kommer att bli komplicerade. Vid preeklampsi (havandeskapsförgiftning), tillväxthämning hos fostret samt blodproppssjukdom finns det idag inget säkert sätt att tidigt i graviditeten veta vilka som kommer att drabbas. Denna oförmåga att kunna föruThe aim of this thesis was to improve background knowledge for making a reliable medical evaluation at the first visit of a woman in her 13th gestational week, to the antenatal clinic. We have focused on the prediction and the risk estimation of preeclampsia, intra-uterine growth restriction (IUGR), and thrombosis. The thesis was based on five studies, in which we have evaluated biochemical analy
Cytogenetic analyses of four squamous cell carcinomas (SCC) of the esophagus showed complex numerical and structural abnormalities. Chromosomal bands or regions preferentially involved were 11q13, 8q10, 21q10, 3p10similar top11, 1p11similar toq11, 5p11similar toq11, and 14p11similar toq11. For the first time, to our knowledge, recurrent aberrations were identified in esophageal SCC, including homo
