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Popular Abstract in Swedish Bakgrund: Det första elektrokardiogrammet (EKG) utfördes 1887 av Augustus Desiré Waller. Det innebar att spänningsskillnader mellan olika delar av hjärtat, under hjärtats arbete dvs. vid upprepade sammandragningar och avslappningar, kunde registreras med elektroder på kroppens yta. Metoden utvecklades vidare av Willem Einthoven, som fick nobelpriset för sitt arbete 1924Background and Methods: Signal-averaging ECG (SAECG), a bioelectrical processing method, is a further development of the conventional ECG. SAECG can detect voltage potentials in the microvolt range and provide a noise-reduced determination of QRS duration. Extended frequency spectra can be analysed. In adult patients after myocardial infarction it is used to predict the risk for arrhythmias and su

Background and Purpose-The proportion of immigrants has increased in Sweden markedly during the last decades, as in many other Western countries. Incidence of stroke has increased during this period. However, it is primarily unknown whether incidence of stroke and stroke subtypes in Sweden is related to country of birth. Methods-Incidence of first-ever stroke was followed during 10 years in a coho

The aims of this thesis were to 1) compare different methods for detection of antibodies against thyroglobulin (TgAb) and thyroid peroxidase (TPOAb), particulary in children with chronic autoimmune thyroditis (AIT), 2) investigate if maternal enterovirus infection is a risk factor for development of AIT in offspring, 3) ascertain the prevalence of thyroid autoantibodies in cord blood sera from chi

Recent studies have indicated a decline in sperm number in the western world during the past 50 years, sperm concentration changing from 113 to 66 millions per mL. Furthermore, significant geographical differences in male reproductive function have been observed. In Finland, the sperm concentration was found to be substantially higher than in Denmark. In parallel, the incidence of testicular cance

We used site-directed mutagenesis to alter the specificity of human cystatin C, an inhibitor with a broad reactivity against cysteine proteinases. Nine cystatin C variants containing amino acid substitutions in the N-terminal (L9W, V10W, V10F and V10R) and/or the C-terminal (W106G) enzyme-binding regions were designed and produced in Escherichia coli. It was discovered that the inhibition profile

Evidence suggests that educational differences in perinatal outcomes have increased in some countries (Eastern Europe) while remained stable in others (Scandinavian countries). However, less is known about the experience of Southern Europe. This study aims to evaluate the association between maternal education and perinatal outcomes derived from birthweight (low birthweight and macrosomia) and ges

The amyloid cascade hypothesis on the pathogenesis of Alzheimer's disease (AD) states that amyloid beta (A beta) accumulation in the brain is a key factor that initiates the neurodegenerative process. A beta is generated from amyloid precursor protein (APP) through sequential cleavages by BACE1 (the major beta-secretase in the brain) and gamma-secretase. The purpose of this study was to characteri

Electrocardiograms are routinely obtained in clinical follow-up of patients with asymptomatic aortic stenosis (AS). The association with aortic valve, left ventricular (LV) response to long-term pressure load, and clinical covariates is unclear and the clinical value is thus uncertain. Data from clinical examination, electrocardiogram, and echocardiogram in 1,563 patients in the Simvastatin and Ez

PURPOSE. Alzheimer disease (AD) and age-related ocular diseases are characterized by inflammation and accumulation of insoluble proteins. We aimed to investigate the detectability and clinical relevance of a panel of AD-related markers, such as Alzheimer peptides and chemokines, in the aqueous humor (AH) samples taken from patients with cataract only, or cataract and 1 other ocular disease. METHOD

Lake sediments and peat deposits from two basins on Nightingale Island (37 degrees S), in the Tristan da Cunha archipelago, South Atlantic, have been analyzed. The studies were focused on the time period 16.2-10.0 cal ka BP, determined by 36 C-14 dates from the two sequences. A wide variety of proxies were used, including pollen and diatom analyzes, biogenic silica content, C and N analyzes, stabl

P>Background Acrylates/methacrylates are volatile substances. There might be a gradual decrease in acrylate/methacrylate allergen content over time in patch test preparations but this has not yet been documented. Objectives To determine the allergen content of acrylates/methacrylates in patch test preparations over time under different storage conditions. Methods Five acrylate/methacrylate allerge

In February 2002, the UNITA rebel leader Jonas Savimbi was shot dead by Angolan Government forces, thereby putting an end to almost four decades of war in Angola. Once peace had been declared, the Government of Zambia together with the Government of Angola and the UNHCR began to make arrangements for the voluntary repatriation of the large Angolan refugee population residing in Zambia. However, du

The topic of this thesis deals with the implementation deficit in the environmental sector that exists within the EU. According to the 25th annual, report from the Commission, there were over 3400 complaints and infringement files under 2007. The environmental sector was the area with the highest number of open cases that concerned non-compliance in 2006 Sweden is however one of the best Member St

Det Palestinska Territoriet har sedan 1967 varit ockuperat av Israel. Som följd av ett stort antal oroligheter och protester mot ockupationen har Israel infört restriktioner för rörlighet inom Västbanken och Gaza. Rörligheten är styrd med hjälp av exempelvis vägspärrar och blockerade vägar. År 2002 började Israel bygga en betongmur runt om och inuti Västbanken, trots att det motsätter sig internatThe Palestinian Territory has since 1967 been occupied by Israel. Following a large number of disturbances as protests to the occupation, Israel has imposed mobility restrictions for Palestinians in the West Bank and Gaza. The mobility is regulated by for example checkpoints, roadblocks and earth mounds. In 2002, Israel started to build a concrete wall around and inside the Palestinian Territory o

In February 2009, ST‐Ericsson was formed as a joint venture bringing Ericsson Mobile Platforms and ST‐NXP Wireless together, creating an industry leader in development and design of wireless semiconductor components and platforms. The new company became one of the top players in wireless semiconductors. During the integration, purchasing of indirect material at ST‐Ericsson was outsourced to an out

The Master Thesis, which is a part of the education to become Master of Science in Engineering, Industrial Engineering and Management, Faculty of Engineering, Lund University, has been written at Gambro in Lund. In 2006 new owners bought Gambro and Gambro has been working on new guidelines and strategies during the past year. The Master Thesis became a part of the work with new strategies and ther

The nonionic low-osmolar contrast medium iohexol was used as marker of glomerular filtration rate (GFR) in 53 patients with stable renal function (group I: n = 32, group II: n = 21). All the patients had clearance values < or = 30 ml.min-1.1.73 m-2 body surface; 40 patients < 20 ml.min-1.1.73 m-2 body surface. Simultaneous determinations of renal clearance and plasma clearance, both as slope clear

In recent decades, obesity has gone from being a problem of first world countries to a global one. It is considered one of the main risk factors for many serious medical conditions. In order to treat and/or prevent obesity different strategies have been considered, one of the most common being the inhibition of lipase, the enzyme that is mainly responsible for lipid digesti

Obesity is a well-established risk factor for colorectal cancer (CRC), but the association with the tumor microenvironment has been sparsely described. Herein, we examined the relationship between pre-diagnostic anthropometry and CRC risk according to tumor immune cell composition, with particular reference to potential sex differences. The density of different immune cell subsets was assessed by

Background: Patients with squamous cell skin cancer (SCC) have an excellent prognosis but second primary cancers (SPCs) weaken survival prospects. Family history is a known risk factor for cancer but whether it is a risk factor for SPC in patients with SCC is not known. Objectives: To quantify the risk of family history on SPCs in patients with SCC and estimate survival probabilities of patients w