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Capsaicinoids are bioactive alkaloids produced by the chili pepper fruit and are known to be the most potent agonists of the human pain receptor TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1). They are currently produced by extraction from chili pepper fruit or by chemical synthesis. Transfer of the biosynthetic route to a microbial host could enable more efficient capsai

Factorization methods are frequently used for structure from motion problems (SfM). In the presence of noise they are able to jointly estimate camera matrices and scene points in overdetermined settings, without the need for accurate initial solutions. While the early formulations were restricted to affine models, recent approaches have been show to work with pinhole cameras by minimizing object s

The human amygdala is involved in processing of memory, decision-making, and emotional responses. Previous studies suggested that the amygdala may represent a neurogenic niche in mammals. By combining two distinct methodological approaches, lipofuscin quantification and 14C-based retrospective birth dating of neurons, along with mathematical modelling, we here explored whether postnatal neurogenes

This letter proposes a co-designed millimeter-wave (mm-wave) and sub-6GHz antenna system. The antenna system consists of four 28GHz mm-wave arrays with reconfigurable radiation patterns and two sub-6GHz antennas fed with two corner capacitive coupling elements (CCEs). Each corner CCE is formed by the connected ground planes of two mm-wave arrays in the shared-aperture configuration. The two CCEs a

The growing diversity of connected devices leads to complex network deployments, often made up of endpoints that implement in- compatible network application protocols. Communication between heterogeneous network protocols was traditionally enabled by hardware translators or gateways. However, such solutions are increasingly unfit to address the security, scalability, and latency requirements of m

With the increasing number of IoT devices deployed, the problem of switching ownership of devices is becoming more apparent. Especially, there is a need for transfer protocols not only addressing a single unit ownership transfer but secure transfer of a complete infrastructure of IoT units including also resource constraint devices. In this paper we present our novel ownership transfer protocol fo

The task of assessing the extent of a gas release during pipeline emergency situations is challenging. Traditional methodologies for risk analysis require significant computer capabilities and time; factors that have traditionally made emergency response teams unable to use gas dispersion modelling during real incidents.

The aim of this paper is to investigate the feasibility and limitations of activity-concentration estimation for 223Ra using SPECT. Phantom measurements are performed using spheres (volumes 5.5 mL to 26.4 mL, concentrations 1.6 kBq mL-1 to 4.5 kBq mL-1). Furthermore, SPECT projections are simulated using the SIMIND Monte Carlo program for two geometries, one similar to the physical phantom and the

A 2D motion estimator can estimate tissue motions and blood flow dynamics more accurately than a 1D motion estimator. In this study, we proposed a simple anti-Aliasing filter to unwrap the phase of the cross spectrum. The proposed method is evaluated by simulation mimicking steady flows, and the magnitude of the true velocity was changed from 200 to 2400 mm s-1. In the simulation, bias error was i

A model independent Lévy expansion method is introduced to describe nearly Lévy shaped squared moduli of Fourier transforms. We apply this method to precisely characterize the most recent elastic scattering data of proton-proton collisions at $$\sqrt s = 13$$ TeV. The results reveal a substructure of protons, which is found to be significantly larger and darker in high energy proton-proton collisi

Bioinformatics is a continuously evolving field since it came into existence and contributing significantly in all major areas of biological sciences. Advanced sequencing technologies and exponential growth in computational resources have facilitated the high-end bioinformatics application in various research areas such as microbiome research in biological system. Bioinformatics contributed signif

This article describes the development and deployment of Physics Toolbox Play, a gamified component of the Android Physics Toolbox Sensor Suite app, that can introduce young children through adults to fundamental physics principles. The app was used successfully in a variety of contexts, including STEM fairs with primary and secondary students and workshops with undergraduate physics majors and pr

We write with great concern in response to the recent systematic review and meta-analysis of cognitive-behavioral therapy (CBT) in pediatric obsessive-compulsive disorder (OCD) by Uhre et al.1 Although the authors’ results consistently support the clinical efficacy of CBT for pediatric OCD, we expect that, much like ourselves, readers will be confused by the discordant and inappropriate conclusion

Introduction: The aim was to assess cost-effectiveness of including pneumococcal vaccination for elderly in a national vaccination programme in Sweden, comparing health-effects and costs of pneumococcal related diseases with a vaccination programme versus no vaccination. Method: We used a single-cohort deterministic decision-tree model to simulate the current burden of pneumococcal disease in Swed

A simple second order feed-forward disturbance attenuation problem is analyzed. The problem has one free parameter, the control weight ρ in the loss function. It is found that controller structure and uniqueness for H∞ - control, in the optimal case, changes when ρ is varied. Sensitivity to initial conditions is also drastically changed. The example is simple enough to allow a solution by formula

INTRODUCTION: Chronic subdural haematomas (CSDHs) are one of the most common neurosurgical conditions. The goal of surgery is to alleviate symptoms and minimise the risk of symptomatic recurrences. In the past, reoperation rates as high as 20%-30% were described for CSDH recurrences. However, following the introduction of subdural drainage, reoperation rates dropped to approximately 10%. The stand

Motivated by the potential of nondiffraction limited, real-time computational image sharpening with neural networks in astronomical telescopes, we studied wavefront sensing with convolutional neural networks based on a pair of in-focus and out-of-focus point spread functions. By simulation, we generated a large dataset for training and validation of neural networks and trained several networks to

Efficient mitigation of power amplifier (PA) nonlinear distortion in multi-user hybrid precoding based broadband mmWave systems is an open research problem. In this article, we carry out detailed signal and distortion modeling in broadband multi-user hybrid MIMO systems, with a bank of nonlinear PAs in each subarray, while also take the inevitable crosstalk between the antenna/PA branches into acc