Filtyp
Recent studies indicate that defective activity of complement factor H (FH) is associated with several human diseases, suggesting that pure FH may be used for therapy. Here, we describe a simple method to isolate human FH, based on the specific interaction between FH and the hypervariable region (HVR) of certain Streptococcus pyogenes M proteins. Special interest was focused on the FH polymorphism
We present how dramatically the nonequilibrium nature of an oppsitely charged polyelectrolyte/surfactant mixture can affect the interfacial properties. We show for the first time that the cliff edge peak in the surface tension of the poly(diallydimethylammonium chloride)/sodium dodecyl surfate system is produced as a direct result of depletion of surface-active material from the bulk solution due
Recent advances in the digital detector technology have paved the way for modalities such as two-dimensional digital mammography (DM) and three-dimensional breast tomosynthesis (BT). In this work, experimental studies were conducted to investigate the influence of reducing the average glandular dose (AGD) on detection of simulated lesions in DM and to compare the diagnostic accuracy of BT and DM.
The aim of our work was to calculate basic mathematical characteristics of payment functional, such as mathematical expectation, variation and expected risk in discrete and continuous market models. In our paper we present a model of financial market in which the entire time interval in the continuous model is divided into steps with exponential distribution, and in the discrete model into steps o
Patients with myocardial infarction (MI) and concomitant chronic obstructive pulmonary disease (COPD) constitute a high-risk group with increased mortality. β-Blocker therapy has been shown to reduce mortality, prevent arrhythmias, and delay heart failure development after an MI in broad populations. However, the effect of β-blockers in COPD patients is less well established and they may also be l
Flow cytometry provides accurate relative cellular quantitation (percent abundance) of cells from diverse samples, but technical limitations of most flow cytometers preclude accurate absolute quantitation. Several quantitation standards are now commercially available which, when added to samples, permit absolute quantitation of CD4+ T cells. However, these reagents are limited by their cost, techn
There is an increasing amount of knowledge on the cytotoxic properties of cyanotoxins, but relatively little is known regarding their fine specificity and mechanisms of action. In this study, we investigated the influence of microcystin-LR and AnTx-a on mouse B- and T-lymphocyte subpopulations in vitro. Cyanotoxins significantly decreased the cell viability after 4 and 24 h, compared to the untrea
Determination of D-arabinitol/L-arabinitol ratios (referred to as D/L-arabinitol ratios) in urine as a tool for the diagnosis of invasive candidiasis was investigated in a prospective study comprising 100 children with cancer. The analyses were made by gas chromatography. Positive D/L-arabinitol ratios were found for 10 of 10 children with confirmed invasive candidiasis, 12 of 23 patients undergoi
Staphylococcal enterotoxin H (SEH) is a bacterial superantigen secreted by Staphylococcus aureus. Superantigens are presented on the MHC class II and activate large amounts of T cells by cross-linking APC and T cells. In this study, RT-PCR was used to show that SEH stimulates human T cells via the V domain of TCR, in particular V10 (TRAV27), while no TCR V-specific expansion was seen. This is in s
Deklinationsdata från sedimentära borrkärnor från sjöarna Kälksjön, Gyltigesjön, Byestadsjön, Mötterudstjärnet, Furskogstjärnet, Frängsjön och Särsjön visar västlig riktning i den övre delen. Denna västliga riktning följer inte paleomagnetiska modeller och är missvisande. Med hjälp av Microsoft Excel har dessa missvisningar korrigerats och använts för att skapa en svensk version av FENNOSTACK, kalDeclination data from cores from swedish lake sediments show a westward declination in the upper part of most cores. This does not align with paleomagnetic models and is therefore considered false. Using Microsoft Excel these false values have been corrected and used in a swedish version of FENNOSTACK called SWESTACK. SWESTACK gives a mean value with 95\% confidence of the declination over the per
Quantification of in vivo proton magnetic resonance spectra (1H-MRS) still commonly involves evaluation of exclusively the real part of acquired spectral signals, but ignoring the information contained in the imaginary component may limit precise identification of individual metabolite contributions. Here, we assess quantification precision relative to SNR and noise correlation for both real and c
Elevated concentrations of inorganic arsenic, one of the most potent environmental toxicants and carcinogens, have been detected in well water around Lake Poopó, Bolivia. This study aimed to assess human exposure to arsenic in villages around Lake Poopó, and also to elucidate whether the metabolism and detoxification of arsenic in this population is as efficient as previously indicated in other An
Several scenarios have been proposed to explain the presence of multiple stellar populations in globular clusters. Many of them invoke multiple generations of stars to explain the observed chemical abundance anomalies, but it has also been suggested that self-enrichment could occur via accretion of ejecta from massive stars on to the circumstellar disc of low-mass pre-main sequence stars. These sc
