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Limb-girdle muscular dystrophy types 2E and F are characterized by skeletal muscle weakness and often cardiomyopathy and are due to mutations in the genes encoding beta- and delta-sarcoglycan. We previously demonstrated that loss of sarcoglycans in smooth muscle leads to constrictions of the microvasculature that contributes to the cardiac phenotype. It is unclear how vasculature abnormalities aff
In developing countries such as Ethiopia, where chronic gastritis and peptic-ulcer disease are the most common endoscopic findings, it is important to study the association between Helicobacter pylori infection and gastroduodenal diseases. Both invasive and non-invasive diagnostic methods were therefore used to investigate 300, consecutive, adult patients with dyspepsia, from the gastrointestinal
Antibody microarray based technology is a powerful emerging tool in proteomics, target discovery, and differential analysis. Here, we report the first study where recombinant antibody fragments have been used to construct large scale antibody microarrays, composed of 127 different antibodies against mostly immunoregulatory antigens. The arrays were based on single framework recombinant antibody fr
PRR recognize conserved structures on pathogenic microbes and are important for the defense against invading microorganisms. However, accumulating evidence indicates that many pathogens have evolved mechanisms to avoid recognition by PRR. One type of PRR is the macrophage scavenger receptor A (SR-A), which has been shown to play an important role in recognition and non-opsonic phagocytosis of path
In 2006 a genetic signal within the gene encoding transcription factor 7-like 2 (TCF7L2) was first reported to be associated with type 2 diabetes. Since then multiple genome-wide association studies have revealed this signal to be among the most strongest associations reported with this disease to date. Furthermore, multiple studies around the world have revealed the global relevance of this locus
BACKGROUND: Butyric acid is produced by degradation of dietary fibre by microbiota and is crucial for maintaining a healthy colon. The physicochemical properties are important for butyric acid formation, and this study aimed to evaluate the use of malting to tailor the functional characteristics of barley dietary fibre. The effect of different steeping conditions was evaluated in laboratory-scale
In this paper, we cast the idea of antithetic sampling, widely used in standard Monte Carlo simulation, into the framework of sequential Monte Carlo methods. We propose a version of the standard auxiliary particle filter where the particles are mutated blockwise in such a way that all particles within each block are, first, offspring of a common ancestor and, second, negatively correlated conditio
The Swedish alternative movement’s place-making activities in the seventies have been understood as an attempt to escape the political sphere. In this thesis, I investigate the ideas and practices of societal transformation seen in rural intentional communities and, to a lesser degree, urban sites. Challenging the idea that such intentional communities were solely concerned with the creation of ‘p
Manufacturing Renaissance, i.e. return of manufacturing to west, has been recently observed. This paper analyzes the patterns observed within each of the four main drivers behind this new phenomenon and delves more deeply into the driver that centers on the new manufacturing technologies such as Additive Manufacturing (AM) and 3D Printing. Next, this paper will make the case that the location of m
Quantitative concentrations measurements using time-resolved laser-induced fluorescence have been demonstrated for nitric oxide (NO) in flame. Fluorescence lifetimes measured using a picosecond Nd:YAG laser and optical parametric amplifier system have been used to directly compensate the measured signal for collisional quenching and evaluate NO concentration. The full evaluation also includes the
Patients with cold urticaria can after exposure to cold air or infusions react with hypotension and cardiovascular collapse. We here report on a patient having a severe cold urticaria who because of angina required myocardial revascularization: She was successfully operated in normothermic cardiopulmonary bypass with cardioplegia.
The effect of a nonspherical particle shape on the dynamics in crowded solutions presents a significant challenge for a comprehensive understanding of interaction and structural relaxation in biological and soft matter. We report that small deviations from a spherical shape induce a nonmonotonic contribution to the crowding effect on the short-time cage diffusion compared with spherical systems, u
Research has been performed model the dynamics of different kinds of wastewater treatment systems. Plant models are built up from standard modules of subprocesses. Available model knowledge has been packaged into suitable software modules and a library of simulation models has been created. The paper describes this library and the kind of simulations that can be performed.
A computer simulated microworld was used to study risk management in a critical infrastructure context. 36 students assumed the role of an electric distribution company Chief Executive Officer (CEO) making decision on how to spend resources between investments in risk reduction and other investments. We studied the effect of differences in terms of the incentives to invest in risk reduction and th
Performing risk assessments for hierarchical, multi-functional systems, such as a municipality, is an activity that requires input from a multitude of actors. In such systems risk assessments can be performed at many system levels and support different types of decisions. For issues that are constrained to a specific sub-system, such as a municipal department, decisions can be preferably taken at
This article deals with an essential problem in the metal cutting industry, the problem of predicting tool wear and tool life. This is also a problem that has been studied by academia for the last century, often with very little added knowledge. The possibility to replace a large number of systematic wear tests with only a few specially designed
