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Crosslinking of small heat-shock proteins (sHsps) by tissue transglutaminase (tTG) is enhanced by stress and under pathological conditions. We here used hexapeptide probes to determine the amine donor (K) and acceptor (Q) sites for tTG in Hsp20. Mass spectrometric peptide mass fingerprinting and peptide fragmentation established that Q(31) and the C-terminal K-162 are involved in inter- and intram
Popular Abstract in Swedish Två observationer tjänar som utgångspunkt för denna avhandling: (1) globaliseringens allt snabbare och mer eller mindre gränslösa flöde av information har medfört ökad press på företag och organisationer, liksom stater och regioner, att ständigt förnya sig för att kunna behålla sin konkurrenskraft. (2) kunskapsintensiv industri tenderar att samlas i geografisk närhet tiThe accelerated speed and intensity of global interconnections in all segments of society during the last couple of decades have had a profound impact on the workings of contemporary capitalism. Increased pressure is put on national and regional economies to continuously upgrade their competitive advantages, at the same time as new learning opportunities occur at a faster rate than ever. For reaso
As society today increasingly understands the impact of transnational corporate operations, an increasing recognition on the part of corporations of their responsibility for social and environmental well being of people in poor countries appears. The norm - Corporate Social Responsibility (CSR) grew out of such logic. The present study explores the extent to which CSR can be expected to contribute
With increasing age, human skeletal muscles gradually decrease in volume, mainly due to a reduced number of motor units and muscle fibers, and a reduced size of type 2 fibers. As a result, progressive weakening and impaired mobility occur. High-resistance strength training is beneficial, even in the very old, and could possibly reverse some of the detrimental effects of age-related weakness. The i
In this study of the transfer function of copies of the Vienna-type differential mobility analyser (DMA) it was found that three, supposedly identical, DMAs exhibited distinct differences with respect to the width of the transfer function. This means that the transfer function of a DMA needs to be determined on an individual basis in order to obtain accurate results from DMA measurements. The size
In this study the feasibility of applying proton-induced X-ray emission spectroscopy (PIXE) to the trace element analysis of human tooth enamel and dentine is investigated. Detection limits on the order of 1–10 ppm are obtained. Depth yields for different elements and proton energies are discussed. Enhancement calculations show that the effect for PIXE analysis is less important than for X-ray ind
Many people have experienced computers not doing what they were expected to do or, perhaps more often, met with computers that deliver faulty results. Frequently, if not always, such behavior is blamed the lack of a complete requirements specification. hi this assertion, it is tacitly understood that if a specification is correct and comprehensive enough then it is possible to avoid computing erro
Popular Abstract in Swedish Extrakt från växten Artemisia annua har dokumenterats för sina anti-malaria egenskaper. Substansen är en mycket effektiv medicin mot malaria och hjälper även mot de former där multi-resistens utvecklats.1979 presenterades strukturen på den aktiva substansen. Den benämns artemisinin och är uppbygd av femton kol innehållandes en peroxid-brygga (två syre kopplade till varaPlants produce a multitude of different compounds that may have biotic effects. Artemisia annua, produces a compound used as a drug against multi-drug-resistant strains of Plasmodium falciparum, the parasite causing malaria. The compound, artemisinin, is a sesquiterpene and is an essential component for the production of artemisinin drugs against malaria. In a first critical step of the biosynthes
In this thesis, the importance of cobalt and humic substances of terrestrial origin for the growth of some bloom-forming marine phytoplankton species is examined. Cobalt (Co) is considered an essential and potentially limiting trace metal for phytoplankton growth and is needed for the synthesis of vitamin B12. Since Co can be mobilised from soils at low pH values, acidification may have led to an
