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NADH:quinone oxidoreductase, or Complex I, is a multi-subunit membrane-bound enzyme in the respiratory chain of many pro- and eukaryotes. The enzyme catalyzes the oxidation of NADH and donates electrons to the quinone pool, coupled to proton translocation across the membrane, but the mechanism of energy transduction is not understood. In bacteria the enzyme consists of 14 subunits, seven membrane

Group G streptococci (GGS) may be of four different species and may infect humans and also animals. S. dysgalactiae equisimilis most commonly cause human GGS infections. These bacteria are part of the normal flora, but can cause pharyngitis, erysipelas and impetigo. In the immunocompromised host severe conditions, such as sepsis and necrotising fasciitis, may develop. In this thesis the interactio

The Knee injury and Osteoarthritis Outcome Score (KOOS) was developed as an extension of the WOMAC Osteoarthritis Index with the purpose of evaluating short-term and long-term symptoms and function in subjects with knee injury and osteoarthritis. The KOOS holds five separately scored subscales: Pain, other Symptoms, Function in daily living (ADL), Function in Sport and Recreation (Sport/Rec), and

This paper investigates the impact of labour-market attachment on first births of foreign-born women in Sweden. The study uses a longitudinal, register-based dataset consisting of the entire population of immigrants from ten nations and a 5-per-cent random sample of natives. The effects of earned income are evident, with increased income levels increasing the probability of becoming a mother for a

Two new antimicrobial metabolites, zopfiellamides A (1) and B (2) were isolated from fermentations of the facultative marine fungus Zopfiella latipes CBS 611.97. Their structures were elucidated by spectroscopic techniques, and they are pyrrolidinone derivatives. (C) 2002 Elsevier Science Ltd. All rights reserved.

Eight secondary metabolites were isolated from submerged cultures of the ascomycete A111-95 during a search for new nematicidal metabolites. (-)-Galiellalactone (7) and compound 2 are metabolites previously obtained from cultures of Galiella rufa while the compounds 1, 3, 4, 5, 6 and 8 (3 and 4 were obtained as an unseparable mixture), were isolated as natural products for the first time. Compound

This thesis is devoted to the characterisation in time and frequency, and to spectroscopic application, of extreme ultraviolet (XUV) pulses. High-order harmonic generation or wave mixing processes were used to produce the pulses in the XUV spectral region. Time-frequency characterisation of femtosecond XUV pulses generated as high-order harmonics is important both for applications in XUV spectrosc

Popular Abstract in Swedish Denna avhandling handlar om hur man kan utläsa klimatiska signaler från klastiska årsvarviga sediment i Ångermanälven i södra Norrland. Avhandlingen bidrar med kunskap till den pågående diskussionen om klimatets- och den hydrologiska cykelns förändringar, framförallt sett ur ett retrospektiv men den behandlar också frågor om framtiden och en eventuellt ökande växthuseffAny future climate variation forced by human activities will be superimposed on the background of natural climate variation. Therefore, before interpreting the present climate and addressing future climate scenarios some knowledge of past climate is necessary. This thesis offers a rare glimpse into a long record of fluvial activity in Central Sweden and illuminates some of the possible forcing age

Crosslinking of small heat-shock proteins (sHsps) by tissue transglutaminase (tTG) is enhanced by stress and under pathological conditions. We here used hexapeptide probes to determine the amine donor (K) and acceptor (Q) sites for tTG in Hsp20. Mass spectrometric peptide mass fingerprinting and peptide fragmentation established that Q(31) and the C-terminal K-162 are involved in inter- and intram

Popular Abstract in Swedish Två observationer tjänar som utgångspunkt för denna avhandling: (1) globaliseringens allt snabbare och mer eller mindre gränslösa flöde av information har medfört ökad press på företag och organisationer, liksom stater och regioner, att ständigt förnya sig för att kunna behålla sin konkurrenskraft. (2) kunskapsintensiv industri tenderar att samlas i geografisk närhet tiThe accelerated speed and intensity of global interconnections in all segments of society during the last couple of decades have had a profound impact on the workings of contemporary capitalism. Increased pressure is put on national and regional economies to continuously upgrade their competitive advantages, at the same time as new learning opportunities occur at a faster rate than ever. For reaso

As society today increasingly understands the impact of transnational corporate operations, an increasing recognition on the part of corporations of their responsibility for social and environmental well being of people in poor countries appears. The norm - Corporate Social Responsibility (CSR) grew out of such logic. The present study explores the extent to which CSR can be expected to contribute