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The recently identified phylogenetic subgroup B5 of fungal glycoside hydrolase family 18 genes encodes enzymes with mannosyl glycoprotein endo-N-acetyl-b-D-glucosaminidase (ENGase)-type activity. Intracellular ENGase activity is associated with the endoplasmic reticulum associated protein degradation pathway (ERAD) of misfolded glycoproteins, although the biological relevance in filamentous fungi
OBJECTIVE: To investigate effects of lipid lowering drug, simvastatin, on apolipoprotein M expression in the hyperlipidemic mice and in hepatic cell line, HepG2 cells. METHODS: Swiss male mice were randomly divided into the high fat group and control group, and were intragastrically fed with 0.9% saline (control group) or lipid emulsion (high fat group) at the daily dosage of 15 ml/kg body weight
A series of QM/MM optimizations of the full protein of [Fe] hydrogenase were performed. The FeGP cofactor has been optimized in the water-bound resting state (1), with a side-on bound dihydrogen (2), or as a hydride intermediate (3). For inclusion of H4MPT in the closed structure, advanced multiscale modeling appears to be necessary, especially to obtain reliable distances between CH-H4MPT+ and th
Pathogenic mycobacteria reside in, and are in turn controlled by, macrophages. However, emerging data suggest that neutrophils also play a critical role in innate immunity to tuberculosis, presumably by their different antibacterial granule proteins. In this study, we purified neutrophil azurophil and specific granules and systematically analyzed the antimycobacterial activity of some purified azu
In the autumn of 2003 newspaper headlines declared that Environment Commissioner Margot Wallström had poison in her blood. After a blood test 28 hazardous chemicals were found, among these DDT that had been abandoned from the market since 1983. In this thesis the reader will find a case study on the EU's chemical Regulation REACH (Regulation, Evaluation, Authorisation of Chemicals). REACH has
Abstract The main influences on growing conditions in pastures and hayfields are grazing and mowing, which regulate the species struggle for space and resources. If the management ceases, this will contribute to a change of the vegetation. A succession starts where the plant cover gradually will change according to a specific pattern. After some time a few competitive species, previously disfavou
The purpose of this study has been to explore the impact of everyday life and the family on women's political participation in India. This has been done by analysing the political life stories of nine women who have all been elected to the local governance system, Panchayati Raj, in the South Indian state of Karnataka. The family often plays a dual role in relation to women's political par
There are two matters, which have important impacts on development of the international intellectual property rights (IPRs). The first is the significant economic importance of the IPRs and its large share in international trade and the second is the protection of IPRs especially in developing and importing countries. More than two thirds of the WTO members are developing countries (DCs) and they
Anti-monopoly laws play an important role to protect the market economy and maintain healthy environment for competition. After China joined WTO, the anti-monopoly problems are becoming more and more obvious. Anti-monopoly rules are needed urgently. It is inspiring that finally the Draft Anti-monopoly Law was passed preliminarily by the State Council in June 2006 after a more than ten years' g
The purpose of this work was to scrutinize and investigate how collective marks can help protect works of Guatemalan artisans' small businesses in the local and international market by promoting them as an organization-association or cooperative. The first chapter contains the introduction of this paper. It is composed by the background of the work, the objective, delimitations, method and out
Minorities are the part of a population that suffer most from conflict and are most likely to become victims of crimes under international law. This is acknowledged by one of the fundamental principles of minority rights law, namely the contribution to peace and stability. Furthermore, the major international legal instruments governing the rights of minorities relate to this objective, by setting
The need for a corporate plan against infringing counterfeit products on your trademark is essential in today’s business climate. This research aims towards filling the current gap of existing literature from a business perspective. Results indicated that businesses need to take a pro-active stand against counterfeits to succeed. If corporations take a passive stand, counterfeits will affect the b
The purpose is to investigate whether the correlation between equity returns and changes in CDS spreads is stronger for sub-investment grade companies than for investment grade companies in the European iTraxx indices.
This paper departs from an interest which has grown exponentially since the beginning of the 2000s’ for cooperation between donor governments and diasporas in development initiatives directed at the diasporas’ country of origin. It notices a discrepancy between identified potential and observed practical results. In an attempt to understand this discrepancy, the thesis seeks to explore the seldom
von Willebrand disease (VWD) is a bleeding disorder caused by inherited defects in the concentration, structure, or function of von Willebrand factor (VWF). VWD is classified into three primary categories. Type 1 includes partial quantitative deficiency, type 2 includes qualitative defects, and type 3 includes virtually complete deficiency of VWF. VWD type 2 is divided into four secondary categori
