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Granulomatosis with polyangiitis and microscopic polyangiitis are ANCA-associated vasculitides (AAVs). The Vasculitis Damage Index (VDI) quantifies damage. This study aims to determine the factors associated with long-term damage in the AAVs.
BACKGROUND: Health-economic models of diabetes are complex since the disease is chronic, progressive and there are many diabetic complications. External validation of these models helps building trust and satisfies demands from decision makers. We evaluated the external validity of the IHE Cohort Model of Type 2 Diabetes; the impact of using alternative macrovascular risk equations; and compared t
The recently identified phylogenetic subgroup B5 of fungal glycoside hydrolase family 18 genes encodes enzymes with mannosyl glycoprotein endo-N-acetyl-b-D-glucosaminidase (ENGase)-type activity. Intracellular ENGase activity is associated with the endoplasmic reticulum associated protein degradation pathway (ERAD) of misfolded glycoproteins, although the biological relevance in filamentous fungi
A series of QM/MM optimizations of the full protein of [Fe] hydrogenase were performed. The FeGP cofactor has been optimized in the water-bound resting state (1), with a side-on bound dihydrogen (2), or as a hydride intermediate (3). For inclusion of H4MPT in the closed structure, advanced multiscale modeling appears to be necessary, especially to obtain reliable distances between CH-H4MPT+ and th
Pathogenic mycobacteria reside in, and are in turn controlled by, macrophages. However, emerging data suggest that neutrophils also play a critical role in innate immunity to tuberculosis, presumably by their different antibacterial granule proteins. In this study, we purified neutrophil azurophil and specific granules and systematically analyzed the antimycobacterial activity of some purified azu
Candida albicans binds and utilizes human complement inhibitors, such as C4b-binding protein (C4BP), Factor H, and FHL-1 for immune evasion. Here, we identify Candida pH-regulated antigen 1 (Pra1) as the first fungal C4BP-binding protein. Recombinant Pra1 binds C4BP, as shown by ELISA and isothermal titration calorimetry, and the Pra1-C4BP interaction is ionic in nature. The Pra1 binding domains w
U-Pb baddeleyite geochronology and geochemistry of mafic cobbles from the similar to 300 Ma Dwyka diamictite on the western boundary of the Kalahari Basin provide new insights into the sub-Kalahari basement. Palaeo-ice flow directions indicate that the origin of the Dwyka diamictite deposits on the border between South Africa and Namibia is from beneath the Kalahari sands to the east or north-east
During the last century (1900s) industrialized forms of agriculture and human activities have caused eutrophication of Baltic Sea waters. As a consequence, the hypoxic zone in the Baltic Sea has increased, especially during the last 50 years, and has caused severe ecosystem disturbance. Climate forcing has been proposed to be responsible for the reported trends in hypoxia (< 2 mg/l O-2) both durin
This review aims to sum up current knowledge on the sensitivity and specificity of ultrasound features suggestive of acute pelvic inflammatory disease (PID).
Satellite remote sensing has the potential to contribute to plant phenology monitoring at spatial and temporal scales relevant for regional and global scale studies. Historically, temporal composites of satellite data, ranging from 8 days to 16 days, have been used as a starting point for satellite-derived phenology data sets. In this study we assess how the temporal resolution of such composites
Risk for drug abuse (DA) is strongly associated with neighborhood social deprivation (SD). However, the causal nature of this relationship is unclear.
Purpose The aim of this study was to examine the incidence of musculoskeletal injuries, site and type of injury, and the most common injury diagnoses in young ballet dancers at the Royal Swedish Ballet School, a public school in Stockholm. Methods This retrospective study of 476 students (297 girls and 179 boys) aged 10-21 years was based on medical records for the period August 1988 to June 1995.
We present measurements of Underlying Event observables in pp collisions at root s = 0 : 9 and 7 TeV. The analysis is performed as a function of the highest charged-particle transverse momentum p(T),L-T in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions coll
Background: The atrial fibrillatory rate (APR), on AZD7009 as compared to placebo, was investigated as a potential biomarker for electrophysiological effect in early antiarrhythmic drug development. Methods: Patients with permanent AF received infusions of AZD7009 and placebo in an exploratory two-way, single-blind, randomized cross-over study. The ECG was continuously recorded, and following QRST
The way relationships between symbols and thoughts are created is a general problem in learning, mainly described as "how students' learn to mean". This general problem raises some basic questions concerning how students' relate understanding to words used in learning. The present research provides an alternative perspective on the relationship between thought and language derived from the phenome
Popular Abstract in Swedish Denna avhandling i nationalekonomi består av fyra stycken självständiga akademiska arbeten. Syftet med avhandlingen är att studera vilken roll hälsoförsäkringar spelar för den privata finansieringen av hälso- och sjukvården i låg- och mellaninkomstländer. Arbetena studerar både effektivitets- och fördelningsfrågor med hjälp av olika typer av metoder. De enskilda arbetenThe thesis consists of an introductory chapter and four independent research papers, summarized as follows. The introductory chapter discusses the role of economics in international health and the policy contributions of each of the particular papers. In addition, the data and the methods that have been used are discussed. Paper I, entitled Community-based health insurance in low-income countries:
Background. In a search for immunosuppressive drugs having novel mechanisms, monocarboxylate transporter (MCT-1) inhibitors were identified that markedly inhibited immune responses. Here, we report the effects of AR-C117977, a potent MCT-1 inhibitor, on alloimmune responses in the rat. Methods. In vitro activity was determined in a rat mixed lymphocyte response (MLR). In vivo activity was tested i
