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RATIONALE: Vascular calcification is a prominent feature of late-stage diabetes, renal and cardiovascular disease (CVD), and has been linked to adverse events. Recent studies in patients reported that plasma levels of osteomodulin (OMD), a proteoglycan involved in bone mineralisation, associate with diabetes and CVD. We hypothesised that OMD could be implicated in these diseases via vascular calci
Hypothesis: The classical STD NMR protocol to monitor solvent interactions in gels is strongly dependent on gelator and solvent concentrations and does not report on the degree of structuration of the solvent at the particle/solvent interface. We hypothesised that, for suspensions of large gelator particles, solvent structuration could be characterised by STD NMR when taking into account the parti
This paper presents a search for decays of the Higgs boson with a mass of 125 GeV into a pair of new pseudoscalar particles, H→aa, where one a-boson decays into a b-quark pair and the other into a muon pair. The search uses 139 fb-1 of proton-proton collision data at a center-of-mass energy of s=13 TeV recorded between 2015 and 2018 by the ATLAS experiment at the LHC. A narrow dimuon resonance is
A search optimized for new heavy particles decaying to two b-quarks and produced in association with additional b-quarks is reported. The sensitivity is improved by b-tagging at least one lower-pT jet in addition to the two highest-pT jets. The data used in this search correspond to an integrated luminosity of 103 fb-1 collected with a dedicated trijet trigger during the 2017 and 2018 s=13 TeV pro
In this article, we propose a novel solution to detect multiple targets using a distributed multiple-input multiple-output (MIMO) radar under the so-called 'defocused transmit-defocused receive' operating mode. The proposed method employs a grid-based data matching algorithm, aiming to associate the target responses to potential target locations, solving the resulting data puzzle that evaluates th
The least absolute shrinkage and selection operator (LASSO) algorithm is a promising method for sparse source location in time–division multiplexing (TDM) multiple–input, multiple– output (MIMO) radar systems, with notable performance gains in regard to resolution enhancement and side lobe suppression. However, the current batch LASSO algorithm suffers from high– computational complexity when deal
Background: The introduction of next-generation sequencing into the diagnosis of neuromuscular disorders has resulted in an increased number of newly identified RYR1 variants. The hypothesis was that there is an increased referral of patients to malignant hyperthermia units without a personal/family history of adverse anesthetic events suspected to be malignant hyperthermia. This retrospective mul
Variational nonlinear chirp mode decomposition (VNCMD) is a recently introduced method for nonlinear chirp signal decomposition that has aroused notable attention in various fields. One limiting aspect of the method is that its performance relies heavily on the setting of the bandwidth parameter. To overcome this problem, we here propose a Bayesian implementation of the VNCMD, which can adaptively
Organizational anticipation involves the ability to foresee and analyze potential threats and disturbances as a means to minimize the likelihood of hazard occurrence and to reduce the potential impacts. Common methods include Risk and Vulnerability Assessments (RVAs) and contingency planning, where potentially harmful events are identified and analyzed, and where measures to prevent, respond to an
Background: Parents of children with complex right ventricular outflow tract (RVOT) anomalies are con-fronted with their child’s need for heart surgery early in life and repeated reoperations later on. Preoperative assessment needs to be performed whenever an indication for reoperation is suspected. The aim was to illuminate the experiences of parents of children diagnosed with RVOT anomalies, in
Background: Core outcome sets (COSs) are important and necessary as they help standardize reporting in research studies. Cranioplasty following traumatic brain injury (TBI) or stroke is becoming increasingly common, leading to an ever-growing clinical and research interest, especially regarding the optimal material, cost-effectiveness, and timing of cranioplasty concerning neurological recovery an
Aims: The present study aimed at testing the hypothesis that atrial fibrillatory rate (AFR) is predictive of sinus rhythm maintenance after electrical cardioversion. Methods and results: The study comprised 32 patients admitted for cardioversion of atrial fibrillation of short duration (mean duration 3.8 ± 7.7 days). AFR was estimated using frequency power spectrum analysis of QRST-cancelled ECG.
Keratins are structural proteins that are abundant in human skin, nails, and hair, where they provide mechanical strength. In the present study, we investigate the molecular mobilities and structures of three keratin-rich materials with clearly different mechanical properties: nails, stratum corneum (upper layer of epidermis), and keratinocytes (from lower layer of epidermis). We use solid-state N
The performance of HVAC equipment, including chillers, is continuing to be pushed to theoretical limits, which impacts the necessity for advanced control logic to operate them efficiently and robustly. At the same time, their architectures are becoming more complex; many systems have multiple compressors, expansion devices, evaporators, circuits, or other elements that challenge control design and
Main recommendations: Endoscopic mucosal resection (EMR) is the standard of care for the complete removal of large (≥ 10mm) nonpedunculated colorectal polyps (LNPCPs). Increased detection of LNPCPs owing to screening colonoscopy, plus high observed rates of incomplete resection and need for surgery call for a standardized approach to training in EMR. 1 Trainees in EMR should have achieved basic co
This article examines the British anarchist Guy Aldred’s involvement in the Indian revolutionary movement from 1909 to 1914 in order to reflect on solidarities and antagonisms between anarchism and anti-colonial movements in the early twentieth century. Drawing on Aldred’s writings, court material and intelligence reports, it explores, first, his decision to print the suppressed Indian nationalist
PURPOSE: Radiation to the bone and exposure to alkylating agents increases the risk of bone cancer among survivors of childhood cancer, but there is uncertainty regarding the risks of bone tissue radiation doses below 10 Gy and the dose-response relationship for specific types of chemotherapy.METHODS: Twelve European countries contributed 228 cases and 228 matched controls to a nested case-control
In her own time, Anne Brontë the writer was regarded as inferior to the two older “Bells”, largely because of the perceived slightness of her first novel and the alleged coarseness and brutality of her second. For the next hundred years, it was accepted that she was a pale second-rater in relation to her sisters. That image has now been discarded; but the notion that Anne Brontë was not quite her
