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Dendritic cells (DC) are a heterogeneous lineage of bone-marrow-derived leukocytes that serve as the link between innate and adaptive immunity. They are professional antigen-presenting cells that play an important protective and regulatory role in both health and disease. This thesis is based upon six original papers that deal with the function and transcription of human DCs, with focus on their r

Directions are given for demonstrating various topics from the other book chapters: The wave-nature of light, singlet oxygen, chromatic adaptation of cyanobacteria, the properties of the human visual system, photoconversion of rhodopsin, photosynthesis of previtamin D, spectral properties of chlorophyll, photoconversion of protochlorophyllide, separation of chloroplast pigments, photoadaptation of

Popular Abstract in Swedish Olika toleransmekanismer kontrollerar immunsystemets aktivitetThe immune system has evolved regulatory mechanisms in order to balance the effects of deleterious immune responses. Such immunological tolerance may be specifically acquired by lymphocytes, although different cells of the immune system participate in the induction and maintenance of tolerance. This thesis work is based on investigations of different tolerance mechanisms induced in CD4+ T lymphocy

The social dimensions of the great transformation from an agrarian to an industrial society are still poorly understood. Today there are challenging opportunities to study such processes in Asia, and to do this against a comparative background of similar transformations elsewhere, for example in Europe, and in the light of theories of social mobility, industrialisation and agrarian change. This st

The Swedish concept of folkbildning (the ‘bildung’ of the people) and its introduction in the mid-1900th century was connected to the advent of Folkhögskolan (the popular adult education) with explicit as well as implicit references to the Danish philosopher Gruntvig’s ideals of education. The broad popular movement which the adult education ideals was incorporated into during the beginning of the

This paper explores wartime relationships and the culture of armed groups in the Democratic Republic of Congo (DRC). Without exceptions, the crises in the Congo must be framed in local-global correlations, i.e. in terms of criminal network activities and its linkages to mining businesses and exploitation of natural resources. In the eastern DRC the boundaries between the different armed groups and

Land subsidence, a silent death, occurs due to various factors like significant reduction in groundwater (GW) levels. It is a widespread phenomenon with irreparable consequences on buildings, infrastructures, and, in severe cases, groundwater aquifers. This study aims to assess the impact of river flow on the acceleration and control of land subsidence in an arid and semi-arid region. To achieve t

Ancient mystery cults have long been considered as a special type of religious practice within Greco-Roman polytheism, defined by initiation rituals of individual and voluntary participation, the transmission of a secret knowledge and an implacable prohibition of disclosure, high levels of emotional arousal, and the promise of salvific benefits in this life and often also in the next. However, rec

This paper examines how the significant events and team member trust in new ventures affect exit from the team. We consider team member exit as an outcome that affects both individuals, the team, and the performance of the new venture. We develop our arguments based on event system theory, which is specifically beneficial to understand how new ventures develop. We test our arguments using a unique

CD4+ T cells that recognize residues 256–270 of type II collagen (CII) associated with the I-Aq (Aq) molecule play a central role in disease pathogenesis in murine collagen-induced arthritis (CIA). Disease is most efficiently induced by immunization with heterologous CII, which elicits heterologous, e.g. bovine, CII256–270:I-Aq-specific T cells that only poorly cross-react with mouse CII. The self

Background Rare cancers are a challenge to clinical practice, and treatment experience, even in major cancer centres to which rare cancers are usually referred, is often limited. We aimed to study the epidemiology of rare cancers in a large population of several countries. Methods We analysed survival by age, sex, subsite, and morphology in 57 144 adults with 14 selected rare cancers diagnosed 198

Recent progress on the nature of short-duration gamma-ray bursts has shown that a fraction of them originate in the local Universe. These systems may well be the result of giant flares from soft gamma-repeaters (highly magnetized neutron stars commonly known as magnetars). However, if these neutron stars are formed via the core collapse of massive stars then it would be expected that the bursts sh

Antibody-based microarray is a novel technology with great potential within high-throughput proteomics. The process of designing high-performing antibody (protein) microarrays has, however, turned out to be a challenging process. In this study, we have developed further our human recombinant single-chain variable-fragment (scFv) antibody microarray methodology by addressing two crucial technologic