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Reduced ROS production triggers arthritis / The role of T cells in arthritis pathogenesis
Popular Abstract in Swedish Brist på fria radikaler kan ge artrit Fagocytiska celler i vårt immunförsvar producerar fria syre-radikaler för att eliminera fagocyterade (uppätna) mikroorganismer. Produktionen av dessa syre-radikaler sker med hjälp av ett enzymkomplex (NADPH oxidas) i cellmembranet samt i membranet på de fagosomer, innehållande mikroorganismer, som bildas i och med fagocytos. MännisThe aim of this thesis is to defend a novel mechanism that triggers arthritis susceptibility in both rats and mice through reduced production of reactive oxygen species (ROS), but also to introduce a novel model for chronic relapsing arthritis. Five papers are included, all of which employ animal models for rheumatoid arthritis and one that also uses animal models for multiple sclerosis. Paper I a
The study of different components in the social process of workplace incivility
Using measurements of fungal activity by isothermal microcalorimetry as a base for modelling fungal growth in buildings
Studies of time-resolved harmonic generation in intense laser fields in xenon
We report preliminary experimental and computational studies of the temporal evolution of the harmonics, generated in xenon, by 50-ps pulses from a Nd: YLF laser, amplified in Nd: glass amplifiers, and focused to produce intensities in the range 1013--5 {\texttimes} 1013 W cm{\textminus}2. Measurements were made of the temporal profiles of the seventh- and ninth-order harmonics using a specially m
The Challenge of Gender Bias in the IT Industry
Contextual Analysis through inquiries into Contextual Dependency is a way to specify and discuss more general issues of unequal distribution of power overall and the importance of gender issues as a specific example. This gives an Information Systems analyst an opportunity to ask some important questions. The sense making activities involved includes efforts to 'visualise' and communicate individu
Non-LTE calculations of radiative forces for thallium in the atmospheres of HgMn stars
Recent observations by the Goddard High-Resolution Spectrograph on the Rubble Space Telescope have dramatically improved our knowledge of the abundance of the heaviest elements in Mercury-Manganese (HgMn) stars (c.f. Leckrone et al. 1992 and Wahlgren et al. 1995). Explaining the observed abundance and isotope anomalies requires improved calculations of radiatively driven diffusion. We briefly revi
Tongue retraction is not so useful after all
This article reports model experiments where vocal tract profiles of high and mid unrounded front and high rounded back vowels were systematically modified to simulate small constriction shifts along the hard or soft palate, in order to test A. M. Bell's century-old proposal that small shifts of tongue arch fronting or retraction would yield audible shifts of vowel timbre. Such differences were cl
Permanent atrial fibrillation in patients without structural heart disease is not associated with signs of infection by Chlamydia pneumoniae and Helicobacter pylori.
OBJECTIVE: The objective of this study was to explore the role of Chlamydia pneumoniae and Helicobacter pylori infections in patients with idiopathic permanent atrial fibrillation. METHODS AND RESULTS: Sera from 72 patients with permanent atrial fibrillation without structural heart disease (mean age 69.6 years, 23 women) were analysed for IgG antibodies against Chlamydia pneumoniae and Helicobact
Preventing heart injury during negative pressure wound therapy in cardiac surgery: assessment using real-time magnetic resonance imaging.
OBJECTIVE: Heart rupture is a devastating complication to negative pressure wound therapy in cardiac surgery. Also, reduced cardiac output during negative pressure wound therapy has been reported. The present study aimed to examine the effects of negative pressure wound therapy on the position of the heart in relation to the thoracic wall using magnetic resonance imaging in a porcine sternotomy wo
Fibroblast phenotypes and their activity are changed in the wound healing process after lung transplantation.
BACKGROUND: Lung transplantation (LTx) is established as a life-saving treatment in end-stage lung disease. However, long-term survival is hampered by the development of chronic rejection, almost synonymous with bronchiolitis obliterans syndrome (BOS). The rejection is characterized by deposition of extracellular matrix in small airways. Fibroblasts/myofibroblasts are the main producers of extrace
Direct observation of the (forbidden) S-1 state in carotenoids
Carotenoids are involved in a variety of biological functions, yet the underlying mechanisms are poorly understood, in part because of the long-standing difficulty in assigning the location of the first excited (S-1) state. Here, we present a method for determining the energy of the forbidden S-1 state, on the basis of ultrafast spectroscopy of the short lived level. Femtosecond transient absorpti
The Cavitation Phenomenon: A Literature Survey
The meaning of the word cavitation is not known or understandable for many people. The definition which is commonly known about such phenomena is that the formation of cavities or bubbles is encouraged by a pressure change in the surroundings. However, cavitation is much more complex. A large amount of research work and studies on the dynamics of the cavitation phenomenon via numerical investigati
Preaching to Pilgrims: Ad vincula sermons at Vadstena Abbey
A survey of form and content of fifteenth-century sermons preached to pilgrims at the Birgittine Abbey of Vadstena, Sweden
Clinic versus patient association sampling of people with Parkinson’s disease.
Experiences for HILAS from integration of human factors into design in the car industry and from working with some human factors keystones.
High Order Boundary Corrections for Computation of Turbulent Flows
Fundamental nonlinearities of the reactor-settler interaction in the activated sludge process
Rendering the Rending of the Veil: What Difference Does It Make?
This article explores how the NT accounts of the rending of the veil in the Temple at the time of Jesus have been interpreted: as a sign of wrath, joy and grief.
Evaluating the impact of climate change on the risk assessment of Nuclear Power Plants
Technical Systems, Structures and Infrastructures (SSI) ought to be designed to be safe under current but also future environmental (climate) conditions. Therefore, there is a need to rigorously identify procedures to systematically consider different climate conditions into the risk assessments. In this paper, we consider climate change in the risk assessment of a Passive Containment Cooling Syst
