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Results from studies using mice deficient in specific complement factors and clinical data on patients with an inherited deficiency of the classical complement pathway component C2 suggest that the classical pathway is vital for immunity to Streptococcus pneumoniae. However, the consequences of defects in classical pathway activity for opsonization with C3b and the phagocytosis of different S. pne

Popular Abstract in Swedish Syfte Syftet med denna avhandling var att undersöka om barn födda i Sverige till invandrare (icke-Svenskar) hade en ökad risk för typ 1 diabetes (T1D) och om immunogenetiska markörer för T1D (HLA och icke-HLA genetiska faktorer samt ö-cellsantikroppar) skiljde sig från svenska T1D barn (Svenskar). Målsättningen var också att analysera ärftliga förutsättningar (T1D och TThis thesis examined whether the offspring of immigrants (non-Swedes) to Sweden are at increased risk of Type 1 Diabetes (T1D) when they are born or live in Sweden. It also evaluated if their T1D and T2D-related genes differed from Swedish patients and whether this genetic heritage determined the types and existence of islet autoantibodies at time of diagnosis and affected the classification of di

Abstract - Vol. I In this Volume of the thesis, which consists of two volumes, a risk analysis framework for application in the maritime transport system of packaged dangerous goods (PDG) is presented. In many countries, dangerous goods risks have been ranked high among public concerns. Such concerns are mainly due to the increasing volume of dangerous goods, human safety and health and environme

De novo differentiation of CD4(+) Foxp3(+) regulatory T cells (induced (i) Tregs) occurs preferentially in the gut-associated lymphoid tissues (GALT). We addressed the contribution of background genetic factors in affecting the balance of iTreg, T helper type 1 (Th1), and Th17 cell differentiation in GALT in vivo following the transfer of naive CD4(+) CD45RB(high) T cells to strains of RAG2-defici

BB rats develop various organ-specific autoimmune diseases, e.g. autoimmune diabetes and thyroiditis and have proven important to dissect genetic factors that govern autoimmune disease development. The lymphopenia (lyp) gene (iddm2) is linked to autoimmune disease development and is a major genetic difference between diabetes-resistant (DR) and diabetes-prone (DP) BB rats. To study the effects of

The Ncf1 gene was recently identified as a strong regulator of severe arthritis in rat. This finding was surprising, because the disease-promoting allele mediated a lower level of reactive oxygen species in NADPH oxidase-expressing cells. We have now investigated a splice mutation of the Ncf1 gene in B10.Q mice, causing a truncated and nonfunctional Ncf1 protein. We found that the mutated Ncf1 led

The role of fluid-phase regulators of complement is to inhibit excessive complement activation and maintain homeostasis in blood. By binding to and inactivating complement components on cell surfaces, they can also protect autologous cells from complement-mediated cytotoxicity and phagocytosis. In this study, we wanted to find out whether C4b-binding protein (C4bp), a fluid-phase regulator of the

Here we explore two new tree-ring parameters, derivedfrom measurements of wood density and blue intensity(BI). The new proxies show an increase in the interannualsummer temperature signal compared to establishedproxies, and present the potential to improve long-term performance.At high latitudes, where tree growth is mainlylimited by low temperatures, radiodensitometric measurementsof wood density

Popular Abstract in Swedish Zeoliter är en grupp av kisel-aluminium-föreningar, med karaktäristiska kanalsystem inuti strukturen, som har fått stor användning inom många områden inom teknik och vetenskap. Zeoliternas viktigaste användningsområden är som torkmedel, som molekylsiktar, som jonbytare och som katalysatorer. Användningen av naturligt förekommande zeoliter är relativt liten jämfört med aA highly dealuminated form of zeolite FAU, ultra-stable zeolite Y (USY), was used as an adsorbent matrix in the purification of proteins. Undesired proteins were removed from a crude preparation by adsorption on USY, increasing the purity of an unadsorbed protein (horse radish peroxidase), or the protein of interest was adsorbed on the zeolite and subsequently eluted through changes in the solutio

In conventional synthetic transmit aperture imaging (STA) the image is built up from a number of low resolution images each originating from consecutive single element firings to yield a high resolution image. This lowers the frame rate and may result in motion artifacts. This paper, describes a method in which all transmitting centers can be excited at the same time and separated at the receiver

In the peak of the 2015 refugee crisis, Sweden stipulated a new law in order to give the system respite while recovering from the pressure that followed from the 162 877 asylum applications Sweden received that year. The Act (2016:752) on temporary limitations of the opportunity to be granted residence permit in Sweden entered to force on 19 July 2016 to apply for three years. The law constitution

Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study RESEARCH ARTICLE Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study Pooja Mehta1, Qian LiID 2, Marisa Stahl1, Ulla UusitaloID 3, Katri Lindfors4, Martha D. Butterworth2, Kalle Kurppa5,6, Suvi Virtanen7, Sibylle Koletz

https://www.teddy.lu.se/sites/teddy.lu.se/files/2023-05/148.pdf - 2026-07-17

Syftet med föreliggande studie var att undersöka experimentledareffekter i ett false belief-test. Utifrån detta syfte konstruerades ett false belief-test i form av en kort tecknad film. Med utgångspunkt i tidigare forskning var hypotesen att de barn som tittade på filmen utan experimentledarens närvaro skulle klara false belief-uppgiften bättre än de som tittade tillsammans med en vuxen. Det fanns

A growing world population confronts humanity and the planet with several challenges due to its increased demand for food, space and energy, implying changes in land use. While agriculture currently provides enough food, it is destroying biodiversity and hence aggravates the planet ́s vulnerability to climate change. A paradigm shift might therefore be needed. Applying a political ecology lens, co

Denna rapport är framtagen som en del av kursen Brandteknisk riskvärdering (VBRN70), som ges vid Lunds Tekniska Högskola. Objektet är en idrottshall i Halmstad, kallad Söndrumshallen. Syftet med rapporten är att utreda personsäkerheten vid ett brandtillbud och målet är att undersöka om Söndrumshallen kan utrymmas på ett säkert sätt vid brand. Vid behov ska även åtgärdsförslag ges. Söndrumshallen b

In line with the Capitalocene narrative, this thesis argues how globally prevailing social* and environmental injustices (including ecological injustices) are driven by systemic capitalist patterns of thinking. In order to enhance social* and environmental justice, it seems thus essential to tackle these. However, there does not yet exist an analytical framework providing a comprehensive overview

Skiljeförfarandet är och har länge varit en populär alternativ tvistlösningsmetod. Detta gäller i synnerhet i internationella kommersiella tvister där parterna önskar ett neutralt förfarande utan koppling till endera parts nationella domstolar. Skiljeförfarandet har dock på senare tid börjat kritiseras för att ofta resultera i långdragna och kostsamma processer för parterna. Mot bakgrund av denna Arbitration is, and has been for long, a popular alternative dispute resolution. This is particularly true for international commercial disputes where the parties wish to have their case tried in a neutral setting. However, arbitration has in recent times received a lot of criticism for being slow and costly. In light of this criticism a new soft law-tool was presented in 2018 called the Rules on