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Introduction: Immune checkpoint inhibitors (ICIs) have transformed lung cancer treatment, yet their effectiveness seem restricted to certain patient subsets. Current clinical stratification on the basis of programmed death ligand 1 (PD-L1) expression offers limited predictive value. Given the mechanism of action, directly detecting spatial programmed cell death protein 1 (PD1)–PD-L1 interactions m
Community-acquired pneumonia (CAP) is a significant health threat for adults. Although conjugate vaccines have reduced pneumococcal CAP incidence in children, Streptococcus pneumoniae-related CAP remains prevalent among older adults. The nasopharynx acts as a reservoir for S. pneumoniae, yet the interplay between this pathogen and the nasopharyngeal microbiome during and after pneumonia remains po
ObjectivesThis nested case–control study aimed to investigate the relationship between components of the Swedish food-based dietary guidelines (SDG) from 2015 and the risk of developing rheumatoid arthritis (RA).MethodsData were obtained from the prospective Malmö Diet and Cancer Study (MDCS) conducted 1991–1996. Diet was assessed at baseline using a validated diet history method. Incident RA case
BACKGROUND: After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year re
NOVELTY - Pretreating non-wood lignocellulosic material containing less than 5 wt.% starch or sugar for producing ethanol from lignocellulose, comprises: (a) adding organic acid or organic acid-producing bacteria to the lignocellulosic material; (b) storing the lignocellulosic material in presence of organic acid for at least 2 weeks in an atmosphere of less than 5% oxygen to obtain organic acid-i
Aspects of labour market integration and employment strategies in relation to reasonable accommodation regulations and the individualised perspective of anti-discrimination legislation. In recent years an unquestionable shift towards disability anti-discrimination legislation can be observed in EC-law (see dir. 2000/78/EC) as well as in national legislations in many parts of the world. Disability
Eftersom snabb teknisk utveckling och globalisering har förändrat sättet på vilket vi anförtror oss personuppgifter till webbplatser för sociala medier samt sökmotorer, har den Europeiska kommissionen föreslagit en ny dataskyddsförordning som kommer att förbättra skyddet för den personliga integriteteten på internet för medborgarna i EU. Då den med stor sannolikhet träder i kraft år 2016 kommer etRapid technological developments and globalisation have profoundly changed the way people entrust their personal data to social media websites and search engines. As a result, the European Commission has proposed a General Data Protection Regulation (GDPR), to enhance online privacy rights for the citizens of the European Union. As the GDPR will most likely enter into force in 2016, one of the maj
The central theme of this thesis is anthropogenic climate change; governments' inability to create an effective, inclusive response mechanism that manages to mitigate anthropogenic emissions; and advocates efforts to coerce States to act by invoking State responsibility in adjudicatory dispute settlement processes. States' failure to act in accordance with scientific risk assessments and
Title: Blockchain Accounting in a Triple-Entry System - Its Implications on the Firm and its Stakeholders, a Case Study on the Request Network. Seminar date: 1st of June 2018 Course: FEKH69 & FEKH89, Degree Project Undergraduate Level, Business Administration, Undergraduate Level, 15 University Credits Points (UPC) or ECTS-cr) Authors: Mahir Hambiralovic & Rasmus Karlsson Advisor: Rolf G L
With the ongoing climate collapse, there is a need for a capital switch, rerouting investments into low carbon infrastructure. Green bonds are a new financial vehicle aimed to facilitate this transition. Through signaling the issuers’ intent to use the proceeds of the bonds towards environmentally beneficial activities, they increase transparency and allow investors to better calculate risks while
In Sweden the number of cars per person has increased since the mid-20th century. With negative impacts on both health and the environment, private ownership of vehicles represents one of the major challenges in urban transport. To move travelers from privately owned vehicles to public transport has shown to be beneficial in reducing carbon emissions. However, in order to create policies that attr
Housing market in Punjab faces number of challenges related to supply, population growth, access to utilities, affordability, and consumer mortgages. In 2017, Punjab, Pakistan, experienced a total urban housing deficit of about 2.3 million units. Due to the Punjab's low supply of affordable housing, home ownership is uneven, with the majority of owners being concentrated in the highest-income
This Bachelor Thesis discusses the American government’s initial fiscal response to the Covid-19 pandemic, the Cares Act, and investigates how the different disposition of money in the two States Mississippi and Alabama has affected entrepreneurship. This comparison is made through a descriptive analysis of how the two states, have distributed, focused and used their Cares Act capital. It is found
Although mRNA SARS-CoV-2 vaccines are generally safe and effective, in certain immunocompromised individuals they can elicit poor immunogenic responses. Among these individuals, people living with HIV (PLWH) have poor immunogenicity to several oral and parenteral vaccines. As the gut microbiome is known to affect vaccine immunogenicity, we investigated whether baseline gut microbiota predicts immu
Target Temperature Management (TTM) is standard care following out of hospital cardiac arrest (OHCA). The aim of the study was to evaluate if treatment temperature (33°C or 36°C) or other predefined variables were associated with the occurrence of bleeding in the TTM study. This study is a predefined, post hoc analysis of the TTM trial, a multinational randomized controlled trial comparing treatme
This work investigates the black hole (BH) population of globular clusters (GCs) in Milky Way- and Andromeda-like galaxies. We combine the population synthesis code MASinGa and the MOCCA-Survey Database I to infer the properties of GCs harbouring a stellar-mass BH subsystem (BHS), an intermediate-mass BH (IMBH), or neither of those. We find that the typical number of GCs with a BHS, an IMBH,
Ethiopia is implementing a Productive Safety Net Program (PSNP) as of 2005, claimed to be the largest social protection program in Africa, which sets out to link relief to development and curb the country’s long over dependence on food aid. This research,thus explores the theoretical framework regarding social protection programs and their ability to bridge the gap between relief and development b
This thesis explores current trends in social and political organising in Northern Syria, in areas controlled by the PYD. The research is built on discussions between eight participants from the Syrian Kurdish-speaking community living in the areas. While most discourses on Syria and the Kurdish-speaking community have a macro-political focus and produce racialising descriptions of “Kurdishness” i
