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Public involvement in health and social care research is increasingly prioritized by policy-makers and research funders. Often, the impact of the involvement is described in terms of how it has contributed to the research outcomes and how it has affected the involved members of the public. There is a dearth of studies reporting from the perspective of researchers themselves of having involved memb

We present the discovery and characterization of two transiting planets observed by TESS in the light curves of the young and bright (V = 9.67) star HD73583 (TOI-560). We perform an intensive spectroscopic and photometric space- and ground-based follow-up in order to confirm and characterize the system. We found that HD73583 is a young (∼500 Myr) active star with a rotational period of 12.08 ± 0.1

Background: Celiac disease (CD) is an immune-mediated inflammatory disease of the intestine in genetically susceptible individuals caused by loss of tolerance to the storage proteins (gluten) in wheat, rye, and barley. Little is known about CD and associated risk factors in Sub-Saharan African countries including Ethiopia. The main aim of the present thesis was to explore how the incidence of celi

Sepsis remains a major clinical challenge due to the limited efficacy of existing therapies in controlling excessive inflammation. The engineered stapled peptide sHVF18, derived from an evolutionarily conserved thrombin innate fold, binds both lipopolysaccharide (LPS) and the LPS-binding groove of CD14, enabling dual targeting of bacterial components and host immune signaling. To define structural

In June 2024, the community of Roxborough Park, Colorado conducted a wildfire evacuation exercise (or drill for short) that was observed by a team of researchers. This collaborative effort involved residents, community organizers, first responders, emergency managers, and researchers. The drill aimed to test and refine evacuation protocols, communication strategies, and coordination among various

Vaccination of neonates and young infants is hampered by the relative immaturity of their immune systems and the lack of safe and efficacious vaccine adjuvants. Immaturity of the follicular dendritic cells (FDCs), in particular, appears to play a critical role for the inability to stimulate immune responses. Using the CD21mT/mG mouse model we found that at 7 days of life, FDCs exhibited a mature p

The recent COVID-19 pandemic has considerably impacted negatively on many aspects of human life such as access to basic necessities including water, energy and food. This article aims to investigate the impact of the COVID-19 lockdown on the water, energy and food accessibility in Katsina state, Nigeria. The survey involved the administration of a questionnaire to a total of 900 households out of

Background: The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index to support local elective surgical system streng

Objectives To examine the associations between socioeconomic position (SEP) and the incidence of serious hand infections—pyogenic flexor tenosynovitis (PFT) and septic arthritis (SA)—as well as risks of opioid overuse following diagnosis using nation-level data. Design In a registry-based nationwide retrospective cohort study, (1) associations between SEP and incidence of PFT/SA; (2) SEP and infec

Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer with high heterogeneity and poor therapeutic responses to standard treatments. The use of herbal medicine for treatment of TNBC is gaining in popularity worldwide due to their better anti-tumor efficacy and less side effects compared to chemotherapy agents. Previous studies have shown that crocin, a natural carotenoid

Toxin-antitoxin (TA) systems are a large group of small genetic modules found in prokaryotes and their mobile genetic elements. Type II TAs are encoded as bicistronic (two-gene) operons that encode two proteins: a toxin and a neutralizing antitoxin. Using our tool NetFlax (standing for Network-FlaGs for toxins and antitoxins), we have performed a large-scale bioinformatic analysis of proteinaceous

This paper presents a statistical combination of searches targeting final states with two top quarks and invisible particles, characterised by the presence of zero, one or two leptons, at least one jet originating from a b-quark and missing transverse momentum. The analyses are searches for phenomena beyond the Standard Model consistent with the direct production of dark matter in pp collisions at

This short playful piece is a result of my participation in the Collaborative Foresight Cycle on the Futures of AI and Sustainability. Hosted by Media Evolution in Malmö between May and June 2022, the Cycle brought together a broad range of actors to co-create and explore the future possibilities of AI in relation to sustainability. This piece is a response to the hopelessness which has arisen due

The International Human Papillomavirus (HPV) Reference Center launches annual global HPV genotyping proficiency panels to enhance the precision and international standardization of HPV genotyping services. This study aims to assess the proficiency levels achieved in the global HPV genotyping proficiency panels conducted in 2022 and 2023, and to evaluate trends in performance over time. The profici

This study examines the role of the Sovereign ESG framework in assessing national progress toward Transformative Change (TC) via environmental, social, and governance metrics. Using data from the World Bank Sovereign ESG Data Portal, we conduct an empirical explorative quantitative study and analyze ESG development across country income groups to identify sustainability challenges and opportunitie