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The State of European Integration : Where Does the EU Stand and in What Direction Is It Heading?

In the concluding chapter, the editors take stock of the state of integration seventy years after the EU’s inception. In the early 2020s, the EU faces once again the fateful question of whether integration should proceed in a federal direction, or whether varied flexible solutions to concrete problems should guide its development instead. The stock-taking is seen against the acute challenges that

Circular economy adoption challenges in the food supply chain for sustainable development

Food loss and waste are major issues in the food industry, and they affect all stages of the food supply chain (FSC). Food loss and waste are linked to environmental deterioration, economic loss, and an increase in hunger. Therefore, the food industry requires sustainable consumption and production (SCP) to reduce losses and waste. The circular economy (CE) concept has become a popular strategy fo

Numerical simulation of saltwater intrusion into Laccadive Island aquifers due to climate change

Saltwater intrusion is a serious environmental problem in coastal subsurface water systems around the world. In the development of subsurface water protection and rehabilitation strategies in the coastal areas, mathematical models play an important role. This paper discusses the role of subsurface water contamination models in planning, management and regulation, with a focus on generic and site s

Feedback Control in the Olivocerebellar Loop

About 40 years ago, a subpopulation of small neurons in the cerebellar nuclei was shown to project to the inferior olive, the source of the climbing fiber input to the cerebellum. This nucleo-olivary projection follows the zonal and probably also microzonal arrangement of the cerebellum so that closed loops are formed between the neurons in the olive, the cerebellar cortex, and the nuclei. Althoug

Exoproducts of the Most Common Achromobacter Species in Cystic Fibrosis Evoke Similar Inflammatory Responses In Vitro

Achromobacter is a genus of Gram-negative rods, which can cause persistent airway infections in people with cystic fibrosis (CF). The knowledge about virulence and clinical implications of Achromobacter is still limited, and it is not fully established whether Achromobacter infections contribute to disease progression or if it is a marker of poor lung function. The most commonly reported Achromoba

Match Theory and the Asymmetry Problem : An Example from Stockholm Swedish

This article discusses what we call the Asymmetry Problem, a theoretical question of how asymmetric properties of prosodic phrasing should generally be accounted for within the framework of Match Theory. Unlike Alignment Theory, in which phrasing asymmetry can be derived by mapping constraints (e.g., Align-XP), Match Theory cannot derive any phrasing asymmetry from mapping (i.e., Match) constraint

A World of Persons

Detta är en studie i det internationella tänkandets subjekt. Människor och stater, om än ofta betraktade som varandras motsatser, delar en sak: de är det internationella tänkandets huvudsakliga subjekt. Avhandlingens argumentet är att orsaken till detta står att finna i det språk genom vilket subjektskap artikuleras, personbegreppets språk, som stipulerar vissa kriterier – i första hand rationalitThis is a study of subjecthood in international thought. Human beings and states, while often held to be opposed to one another, share this: they are international thought’s key subjects. The following chapters attempt to answer the question of why that is. The main argument advanced is that this is because of the particular language in which subjecthood is articulated, the language of personhood,

Biodiversity offsets may miss opportunities to mitigate impacts on ecosystem services

Biodiversity offsets are most commonly used to mitigate the adverse impacts of development on biodiversity, but some offsets are now also designed to support ecosystem services (ES) goals. Here, we assemble a global database of biodiversity offsets (n = 70) to show that 41% already take ES into consideration, with the objective of enhancing cultural, regulating, and provisioning services. We found

The Preterm Heart in Childhood : Left Ventricular Structure, Geometry, and Function Assessed by Echocardiography in 6-Year-Old Survivors of Periviable Births

BACKGROUND: Preterm birth has been associated with increased risk of cardiovascular morbidity in adult life. We evaluated whether preterm birth is associated with deviating cardiac structure and function before school start.METHODS AND RESULTS: In total, 176 children aged 6 years and born extremely preterm (EXPT; gestational age of 22-26 weeks) and 134 children born at term (control [CTRL]) were s

Informella stämledare : Körledares erfarenhet av samarbete mellan sångarna i körstämman

Informal leaders in the choral voice.Choir leaders’ experience of collaboration between the choristers.Most choirs and choir leaders have the aim to make the individual voices soundas unison as possible in the different choral voices, according to both timing,synchronisation and vocal blend.The aim of the present study was to investigate experienced choir leaders’experience and understanding of po

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

Peroxisome proliferator-activated receptor gamma (PPARG) is a master transcriptional regulator of adipocyte differentiation and a canonical target of antidiabetic thiazolidinedione medications. In rare families, loss-of-function (LOF) mutations in PPARG are known to cosegregate with lipodystrophy and insulin resistance; in the general population, the common P12A variant is associated with a decrea

Development and Life Cycle Assessment of Polyester Binders Containing 2,5-Furandicarboxylic Acid and Their Polyurethane Coatings

This work presents a new polyester binder based on 2,5-furandicarboxylic acid (FDCA) as precursors of polyurethane (PU) coatings. The new 100% bio-based structure is composed of four different monomers such as glycerine (Gly), 1,3-propanediol (1,3-PD), 2,5-furandicarboxylic acid (FDCA) and succinic acid (SA). The corresponding PU coating was obtained by crosslinking with a conventional polyisocyan

ALPPS Improves Resectability Compared with Conventional Two-stage Hepatectomy in Patients with Advanced Colorectal Liver Metastasis : Results from a Scandinavian Multicenter Randomized Controlled Trial (LIGRO Trial)

Objective: The aim of the study was to evaluate if associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) could increase resection rates (RRs) compared with two-stage hepatectomy (TSH) in a randomized controlled trial (RCT). Background: Radical liver metastasis resection offers the only chance of a cure for patients with metastatic colorectal cancer. Patients with colo

The Church of Yimrhane Kristos : An Archaeological Investigation

The purpose of this thesis is to augment our understanding of the Church of Yimrhane Kristos, and the Lasta period in which it was built, from the study of a variety of source materials. Due to the fact that the Lasta period suffers from the absence of adequate and reliable literary sources, this study largely depends on the elements of historic buildings as the basic data source. Using archaeomet

Incidence and trends of basal cell carcinoma in Sweden : A population-based registry study

BACKGROUND: Basal cell carcinoma (BCC) is the most common skin cancer. Incidence is largely unknown because of incomplete, or lack of, registration in most countries.OBJECTIVES: To assess current incidence rates and recent trends for BCC in the Swedish population.METHODS: Patient- and tumour-related features of all histologically confirmed BCC tumours diagnosed in Sweden from 2004 to 2017 were ext

Formation of supermassive black holes in galactic nuclei – I. Delivering seed intermediate-mass black holes in massive stellar clusters

Supermassive black holes (SMBHs) are found in most galactic nuclei. A significant fraction of these nuclei also contains a nuclear stellar cluster (NSC) surrounding the SMBH. In this paper, we consider the idea that the NSC forms first, from the merger of several stellar clusters that may contain intermediate-mass black holes (IMBHs). These IMBHs can subsequently grow in the NSC and form an SMBH.