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Euro50 is a proposed optical telescope with an equivalent primary mirrordiameter of 50 m. Partners of the collaboration are institutes inSweden, Spain, Ireland, Finland, and the UK. The telescope will have asegmented primary mirror and an aplanatic Gregorian configuration withtwo elliptical mirrors. For a 50 m telescope there would be noeconomical advantage in going to a spherical primary. The siz
Popular Abstract in Swedish Antalet människor som insjuknar i cancer (cancerincidensen) runtom i världen ökar, exempelvis i Sverige har antalet diagnosticerade tumörer ökat med i snitt 2.1% per år de senaste 20 åren. Denna ökning förklaras bland annat av vår ökade livslängd och vårt val av livsstil. Trots detta har antalet människor som dör i cancer minskat de senaste 20 åren. Dessa motsägelsefullThe continual increase in incidence of cancer has created an urgent need for improved methods for diagnosis, prognosis and/or treatment. In this context, the field of biomarker research has expanded immensely during the last few years. This thesis, based on four original papers, revolves around protein biomarker discovery in cancer. For this purpose, an in-house design recombinant antibody microar
In the mythological texts from Ugarit in modern Syria (probably 14th century BC), the motif of the deadly, drought-inducing sun plays a large part: the burning sun casts its destroying rays as a result of the power and influence of death, especially the god of death himself, Mot. However, the solar goddess Shapshu is in other cases portrayed as quite a benevolent entity. In this paper, I discuss t
Today embedded system development is a complex task. To aid the engineers new methodologies and languages are emerging. During the development the system is modelled using different tools and languages. Transformations between the models are traditionally done manually. We investigate the automation of this process, specifically we are looking at automatic UML to SystemC transformation. In this pa
By partitioning a hardware design into several blocks and adjusting the voltage of the different blocks individually, an overall power consumption reduction is possible. An algorithm and a hardware solution for assigning two supply voltages to a design divided into blocks is presented. The two supply voltages are optimized using an on-chip controller. The on-chip controller assigns one of the two
In this paper an OFDM timing synchronization ASIC is presented. The proposed synchronization unit can be used in any OFDM system. The algorithm is based on the correlation introduced by the cyclic prefix, which is exploited in the time domain where the time offset is estimated. Although the algorithm is too complex to be implemented on today's most powerful standard DSP, a hardware architecture th
Quantification of in vivo proton magnetic resonance spectra (1H-MRS) still commonly involves evaluation of exclusively the real part of acquired spectral signals, but ignoring the information contained in the imaginary component may limit precise identification of individual metabolite contributions. Here, we assess quantification precision relative to SNR and noise correlation for both real and c
Gene amplification is a crucial process in cancer development, leading to the overexpression of oncogenes. It manifests cytogenetically as extrachromosomal double minutes (dmin), homogeneously staining regions (hsr), or ring chromosomes (r). This study investigates the prevalence and distribution of these amplification markers in a survey of 80 131 neoplasms spanning hematologic disorders, and ben
This study presents a thermodynamically consistent continuum damage model for fiber-based materials that combines elastoplasticity and damage mechanisms to simulate the nonlinear mechanical behavior under in-plane loading. The anisotropic plastic response is characterized by a non-quadratic yield surface composed of six sub-surfaces, providing flexibility in defining plastic properties and accurac
This chapter presents the personal experiences of an activist researcher. It describes the role of activism in Gaborit's trajectory from being a student research assistant, through PhD candidate to postdoctoral fellow, and finally, to breaking with academia. This chapter discusses the inherent contradictions of working against hegemonic structures that enable social harm, from within the hegemonic
We examined the effect of 17alpha-ethinylestradiol on immunity of the Western fence lizard, Sceloporus occidentalis. Injection of 17alpha-ethinylestradiol resulted in dose-dependent suppression of peripheral blood leukocyte levels as determined by cell counts, whereas total spleen cell levels were decreased only at higher doses of 17alpha-ethinylestradiol. In contrast, spleen cell proliferation wa
