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We consider a popular model for long-duration gamma-ray bursts, in which the progenitor star, a stripped helium core, is spun up by tidal interactions with a black hole companion in a compact binary. We perform population synthesis calculations to produce a representative sample of such binaries, and model the effect that the companion has on material that falls back on to the newly formed black h
Antibody-based microarrays are a rapidly evolving affinity-proteomic methodology that recently has shown great promise in clinical applications. The resolution of these proteomic analyses is, however, directly related to the number of data-points, i.e. antibodies, included on the array. Currently, this is a key bottleneck due to limited availability of numerous highly-characterized antibodies. Her
The article analyzes the recent genre of Islamic children’s picture books, originally produced as a means of religious socialization for the British Muslim communities, but marked on a global Islamic market. Particular attention is devoted to the visual norms of the books produced by one of the pioneering publishers of Islamic children’s literature, the Islamic Foundation. With one foot in the ped
BACKGROUND: Folate is involved in DNA synthesis and methylation and may thereby influence carcinogenesis. OBJECTIVES: We examined plasma folate (P-folate) concentration in relation to genotypes of the folate-metabolizing enzyme methylenetetrahydrofolate reductase [MTHFR 677C<--T (rs1801133) and 1298A<--C (rs1801131)]. We also explored whether P-folate was associated with risk of postmenopausal bre
B-cell development into antibody producing cells is a complex process that relies on the tightly controlled production of hundreds of genes and proteins. A B-cell is activated through the B-cell receptor (BCR) and this activation is modified by different co-stimulatory or inhibitory co-receptors. The concerted action of signals from BCR and from co-receptors decides the fate of the B-cells. The ma
Monoclonal anti-collagen type II antibody CIIC1 is an arthritogenic autoantibody, which induces arthritis in mice. We crystallized and solved the structure of CIIC1 Fab molecule. Analysis of structure revealed an interaction between the CDR regions of one Fab to the CH1 domain of another Fab, which resembles an antibody-antigen interaction. ELISA experiments confirmed the cross-reactivity of both
Treatment and management of chronic wounds is a large burden on the health sector and causes substantial suffering for the patients. We believe that 13 lactic acid bacteria (LAB) symbionts isolated from the honey crop of the honeybee are important players in the antimicrobial action of honey, by producing antimicrobial substances and can be used in combination with heather honey as an effective tr
The binaries PSR J1141-6545 and PSR B2303+46 each appear to contain a white dwarf that formed before the neutron star. We describe an evolutionary pathway to produce these two systems. In this scenario, the primary transfers its envelope on to the secondary, which is then the more massive of the two stars, and indeed sufficiently massive later to produce a neutron star via a supernova. The core of
Mid-infrared polarization spectroscopy (IRPS) was applied to detect HCl in flames. For the first time, sensitive and nonin trusive HCl detection with a manner of high spatial- and temporal-resolution in harsh reactive gas flow has been demonstrated in this work. In an atmospheric pressure premixed CH4/O-2/Ar flat flame, trace level HCl was prepared by seeding small amount chloroform through the Ar
Multiple Sclerosis (MS), is a neurologic, autoimmune disease characterized by CNS immune cell infiltration and demyelination. To experimentally study MS, we have utilized the mouse model Experimental Autoimmune Encephalomyelitis (EAE). EAE is induced through immunization with myelin antigens, which elicits an autoreactive Th1 cell response. Encephalitogenic T cells migrate into the CNS where they
The growing field of biotechnology is in constant need of proteins that can function as recognition tools for separational, analytical and therapeutic purposes. Different molecular engineering approaches are applied on natural proteins in order to create variants with desired properties. This thesis is based on five original papers that deal with selection, characterisation and application of nove
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Components derived from cartilage have been suggested to maintain the inflammation in joints in arthritis. Small leucine-rich repeat proteins (SLRPs) are structural components of cartilage important in organizing the meshwork of extracellular matrix components. It has recently been shown that the SLRP fibromodulin interacts with complement initiator C1q, leading to complement activation. The compl
Artificial neural networks (ANNs) are nonlinear pattern recognition techniques that can be used as a tool in medical decision making. The objective of this study was to develop an ANN model for predicting survival in patients with pancreatic ductal adenocarcinoma (PDAC).
CD4+ T cells that recognize residues 256–270 of type II collagen (CII) associated with the I-Aq (Aq) molecule play a central role in disease pathogenesis in murine collagen-induced arthritis (CIA). Disease is most efficiently induced by immunization with heterologous CII, which elicits heterologous, e.g. bovine, CII256–270:I-Aq-specific T cells that only poorly cross-react with mouse CII. The self
Background Rare cancers are a challenge to clinical practice, and treatment experience, even in major cancer centres to which rare cancers are usually referred, is often limited. We aimed to study the epidemiology of rare cancers in a large population of several countries. Methods We analysed survival by age, sex, subsite, and morphology in 57 144 adults with 14 selected rare cancers diagnosed 198
Recent progress on the nature of short-duration gamma-ray bursts has shown that a fraction of them originate in the local Universe. These systems may well be the result of giant flares from soft gamma-repeaters (highly magnetized neutron stars commonly known as magnetars). However, if these neutron stars are formed via the core collapse of massive stars then it would be expected that the bursts sh
Detta arbete behandlar frågan om vad det inom migrationsrätten gällande beviskravet sannolikt innebär ur ett sannolikhetsteoretiskt perspektiv vid tillämpning framför allt av utlänningslagen (2005:716) 4 kap. 1 §. Utvald del av denna paragraf tolkas och delas upp i delteman. Utifrån dessa delteman undersöks vad som måste uppnå vilken sannolikhet och hur sannolikheten för olika delteman påverkar saThis is a thesis on the issue of what the evidentiary requirement within the field of migration law, probable, implies, from a probabilistic point of view, especially when applying the 1st article of the 4th chapter in the Swedish Aliens Act (2005:716), about refugee status. A selected part of this article is interpreted and divided into sub-themes of proof (these could also be referred to as prop
