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Popular Abstract in Swedish En central fråga av både teoretisk och praktisk betydelse är varför vissa företag är mer framgångsrika - vilket ofta uttrycks som att de har större konkurrensfördelar - än andra. Speciellt uppkommer frågan då vissa fabriker inom samma företag år efter år uppvisar ett bättre ekonomiskt resultat än andra. Fokus i denna avhandling är att förstå varför så sker inom ett utvaThe most central question in the strategic management literature is why some firms are more successful than others, often expressed as an aim to understand sources of competitive advantage. In this thesis, an empirical observation is made that a number of manufacturing plants belonging to the same firm show sustainable differences in financial success, and the question is why. The main theoretical

A method for the reconstruction and motion problems is presented, under the assumption that a number of point correspondences in a pair of images are known. A geometric and algebraic theory is based on invariance properties of point configuration under affine and projective transformations. In particular, a characterization of those image pairs which correspond to the same point configuration in a

We investigate whether the recently observed population of high-velocity white dwarfs can be derived from a population of binaries residing initially within the thin disc of the Galaxy. In particular, we consider binaries where the primary is sufficiently massive to explode as a Type II supernova. A large fraction of such binaries are broken up when the primary then explodes as a supernova, owing

Experimental studies are carried out to investigate the heat transfer characteristics involving an impinging jet with a shallow-angle in a crossflow. A rib is applied to control the jet impingement heat transfer Liquid crystal technique is employed to measure the wall temperature and obtain the heat transfer coefficients. In the study, the Reynolds number for the crossflow is 80,000 and the Reynol

In order to identify the protein responsible for a dopamine peroxidizing activity, previously described in human normal and parkinsonian substantia nigra by our group, we developed non-denaturing polyacrylamide gel electrophoresis conditions, mimicking the characteristic colour in vitro reaction, resulting from cyclic oxidation of dopamine (DA). After separating protein mixtures from human normal

Human C4b-binding protein (C4BP) is a soluble, multiple-subunit inhibitor of complement that circulates in blood. Recently C4BP was shown to bind DNA, reduce DNA release from necrotic cells and limit DNA-mediated complement activation in solution. Herein we employed nuclear magnetic resonance spectroscopy to measure chemical shift perturbations and used them to restrain the computational docking o

It is widely believed that DC, but not macrophages, prime naïve T cells in vivo. Here, we investigated the ability of CD68-expressing cells (commonly defined as macrophages) in priming autoreactive T cells and initiating collagen-induced arthritis (CIA) in the mouse. For this purpose, a transgenic mouse was developed (MBQ mouse) where macrophages exclusively expressed the MHC class II H2-A(q) (A(q

The existence of T cells restricted for the MHC I-like molecule CD1 is well established, but the function of these cells is still obscure; one implication is that CD1-dependent T cells regulate autoimmunity. In this study, we investigate their role in experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, using CD1-deficient mice on a C57BL/6 background. We show t

The function of the nucleolus is intimately connected to cell proliferation, division and growth. Many cancer cells have enlarged nucleoli, and several nucleolar proteins have been linked to tumorigenesis. In order to find proteins whose expression is altered in the nucleoli of leukemic cells, we carried out two-dimensional difference gel electrophoresis (2-D DIGE) analyses. Prohibitin (PHB) and T

Leukemic cells from 85 children with newly diagnosed precursor B-lineage ALL were tested for in vitro drug sensitivity to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. There was a significant correlation between MRD day 29 and in vitro sensitivity to prednisolone (p < 0.001) and doxorubicin (p = 0.01 7), drugs administered during induction therapy. In patient

The detection of the formyl radical (HCO) is of great interest in the field of combustion research since it can provide information about the local heat release (HR) rate which is a key parameter in the understanding of combustion processes. Unfortunately, due to the low signal level, HCO planar laser-induced fluorescence (PLTF) has so far not been applicable for single-shot imaging, which is nece

People aged 60 or more are the most frequent users of healthcare services. In this age range, however, both frequent and infrequent users can be found. Frequent users have high rates of illnesses. Previous research has found that the frequency may be influenced also by psychological and social factors. The aim of this study was to investigate to what degree such factors add to the explanation of d

Type 1 diabetes mellitus (T1DM) is an autoimmune disorder in which genetics and environmental factors play a role. Among the environmental factors, viruses (especially Coxsackie virus B [CBV]), and among genetic markers, human leukocyte antigen (HLA) DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8) and DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2), and major histocompatibility complex class I chain-related gene-A (M

Background-Atrial fibrillation (AF) is heterogeneous at the clinical and molecular levels. Association studies have reported that common single-nucleotide polymorphisms in KCNE1 and SCN5A may predispose to AF In this study, we tested the hypothesis that specific AF-associated genotypes confer variation on the appearance of AF assessed by analysis of fibrillatory rate of the atria. Methods and Resu

This paper presents a new fast approach to improving stability in polynomial equation solving. Gröbner basis techniques for equation solving have been applied successfully to several geometric computer vision problems. However, in many cases these methods are plagued by numerical problems. An interesting approach to stabilising the computations is to study basis selection for the quotient space C[