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Within-host competition between Borrelia afzelii ospC strains in wild hosts as revealed by massively parallel amplicon sequencing.

Infections frequently consist of more than one strain of a given pathogen. Experiments have shown that co-infecting strains often compete, so that the infection intensity of each strain in mixed infections is lower than in single strain infections. Such within-host competition can have important epidemiological and evolutionary consequences. However, the extent of competition has rarely been inves

CD11b(+)Ly6C(++)Ly6G(-) cells show distinct function in mice with chronic inflammation or tumor burden

Background: S100A9 has been shown to be important for the function of so called Myeloid Derived Suppressor Cells (MDSC). Cells with a similar phenotype are also involved in pro-inflammatory processes, and we therefore wanted to investigate the gene expression and function of these cells in animals that were either subjected to chronic inflammation, or inoculated with tumors. Methods: CD11b(+)Ly6C(

On the approximability of maximum and minimum edge clique partition problems

We consider the following clustering problems: given a general undirected graph, partition its vertices into disjoint clusters such that each cluster forms a clique and the number of edges within the clusters is maximized (Max-ECP), or the number of edges between clusters is minimized (Min-ECP). These problems arise naturally in the DNA clone classification. We investigate the hardness of finding

Bandwidth allocation in Bluetooth scatternets

This paper deals with bandwidth allocation in a Bluetooth scatternet. The proposed assignment of transmission rights provides a controlled traffic transfer between Bluetooth piconets and represents a key component in an ad-hoc wireless Bluetooth network in order to provide with efficient data packet passing within and across piconets. This assignment is obtained by executing a distributed algorith

To Boldly Go Where No Man has Gone Before: Seeking Gaia's Astrometric Solution with AGIS

Gaia is ESA's ambitious space astrometry mission with a foreseen launch date in late 2011. Its main objective is to perform a stellar census of the 1,000 million brightest objects in our galaxy (completeness to V=20 mag) from which an astrometric catalog of micro-arcsec (μas) level accuracy will be constructed. A key element in this endeavor is the Astrometric Global Iterative Solution (AGIS) - th

A Molecular Dissection of Mantle Cell Lymphoma - From gene expression analysis to functional evaluation of selected targets

Popular Abstract in Swedish Årligen diagnostiseras cirka 60 000 nya fall av cancer i Sverige (Socialstyrelsen, 2015), och var tredje person beräknas få en cancerdiagnos under sin livstid. Trots stora framsteg inom forskning och utveckling är cancer, näst efter hjärt- och kärlsjukdomar, den vanligaste dödsorsaken i vårt samhälle. Bland de tio vanligaste formerna av cancer hör lymfom, vilket är etMantle cell lymphoma (MCL) is an aggressive form of B-cell lymphoma (BCL) with poor clinical outcome. In this thesis, which is based upon five original papers, different approaches have been used to pinpoint and investigate molecular events that promote MCL tumor growth, progression or resistance to treatment. The aim has been to identify novel targets with the potential to eradicate malignant cel

Flexible baseband transmitter for OFDM

To fully utilize the available spectrum for a wireless communication system it is feasible to adapt to different situations on the channel. In this paper a flexible OFDM transmitter is presented together with basic theory behind OFDM transmission. It is shown that high flexibility can be obtained with a reasonable amount of additional hardware. Part of the design, the FFT-processor, has already be

Sodium Butyrate Enhancement of Protein Expression

We studied in chimeric EGFP-Photinus luciferase HeLa cells the expression of fluorescence and luminescence in different cell culture conditions (medium with or without Serum, static or dynamic conditions, in suspension or on microcarriers) as a model to follow the productivity of a recombinant protein. By studying the effect of Butyrate known as general but unpredictable stimulating agent for prot

Artificial Neural Networks for Diagnoses of Dysfunctions in Urology

In this article we evaluate the work out of artificial neural networks as tools for helping and support in the medical diagnosis. In particular we compare the usability of one supervised and two unsupervised neural network architectures for medical diagnoses of lower urinary tract dysfunctions. The purpose is to develop a system that aid urologists in obtaining diagnoses, which will yield improved

Chronic Arthritis in Rats; Pathogenesis and genetic factors

Popular Abstract in Swedish Ärfltiga faktorer orsakar ledgångsreumatism Reumatoid artrit (RA) även kallat ledgångsreumatism är en ledsjukdom som drabbar 1% av befolkningen, framförallt kvinnor. Orsaken till sjukdommen är inte känd, men man tror att det finns en ärftlig faktor som avgör om en viss individ kan utveckla reumatoid artrit eller inte. Den genetiskassociationen man idag vet om är till mThe immune pathology and MHC association of chronic arthritis was studied in three rat models for reumatoid arthritis (RA). Susceptible rat strains develop a T cell dependent chronic disease after immunization with rat collagen type II (CII). The LEW rat does not develop arthritis after immunization with rat CII, but a heterologous immune response to pepsin can break the tolerance to CII and rende

Initial, transient and steady state evaporative resistance of impermeable protective clothing

The measured water vapour resistances of clothing ensembles differ among laboratories particularly for impermeable clothing. Due to the moisture transfer in the clothing ensemble, evaporative heat losses in initial, transient and steady state phases are different. The purpose of this study was to investigate moisture absorption inside underwear and outer layer as a function of time, to quantify th

Interlaboratory tests on thermal foot models

In order to compare measurements in different laboratories and with different models and measuring principles a small Round Robin test was suggested. 8 test institutions were able to join the study (with foot model sizes from 254 mm to 275 mm and test boot sizes from 41 to 44). We got also a declaration of interest from several other institutes that were not able to carry out the tests. A database

Rule of Succession and Political Participation in the GCC States

The chapter discusses problms of succession in the GCC states and how they are likely to impact regimes' responses to domestic and foreign demands for political reforms. It attempts to put succession issues in the context the emerging new order in the Gulf.