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Lack of supportive evidence for the use of immunohistochemical staining to identify occult regional lymph node metastases in primary lung cancer.

Immunohistochemical (IHC) staining for the identification of nodal occult metastases (OM), not detected by routine histological examination, has been proposed for improved staging, prognostication and decision of adjuvant treatment in surgically treated primary lung cancer. In a prospective study, we analysed 178 cases of primary lung cancer stage I-III (N0-N1) for OM by immunostaining lymph node

A hydrogeological study of the Nhandugue River, Mozambique – A major groundwater recharge zone

The Nhandugue River flows over the western margin of the Urema Rift, the southernmost extension of the East African Rift System, and marks the north-western border of Gorongosa National Park, Mozambique. It constitutes one of the major indispensable water resources for the ecosystem that the park protects. Our study focused on the hydrogeological conditions at the western rift margin by resistivit

The hunt for the Milky Way's accreted disc

The Milky Way is expected to host an accreted disc of stars and dark matter. This forms as massive greater than or similar to 1 : 10 mergers are preferentially dragged towards the disc plane by dynamical friction and then tidally shredded. The accreted disc likely contributes only a tiny fraction of the MilkyWay's thin and thick stellar disc. However, it is interesting because (i) its associated '

TGF-β-mediated epithelial–mesenchymal transition and tumor-promoting effects in CMT64 cells are reflected in the transcriptomic signature of human lung adenocarcinoma

Epithelial–mesenchymal transition (EMT) is a cellular process during which epithelial cells acquire mesenchymal phenotypes. Cancer cells undergo EMT to acquire malignant features and TGF-β is a key regulator of EMT. Here, we demonstrate for the first time that TGF-β could elicit EMT in a mouse lung adenocarcinoma cell line. TGF-β signaling activation led to cell morphological changes corresponding

Multiple conceptualizations of nature are key to inclusivity and legitimacy in global environmental governance

Despite increasing scientific understanding of the global environmental crisis, we struggle to adopt the policies science suggests would be effective. One of the reasons for that is the lack of inclusive engagement and dialogue among a wide range of different actors. Furthermore, there is a lack of consideration of differences between languages, worldviews and cultures. In this paper, we propose t

A Note on Terminology in Multigrid Methods

We compare terminology used in the literature on multigrid methods for compressible computational fluid dynamics to that used in linear multigrid theory. Several popular iterative and direct smoothers are presented side-by-side using the same terminology. We argue for greater analysis of these methods in order to place them into a more rigorous framework and to identify the most promising candidat

Immunohistochemical analysis of cannabinoid receptor 1 expression in steatotic rat livers

The primary aim of the present study was to determine the expression levels of cannabinoid receptor type 1 (CB1) in steatotic rat livers. The secondary aim was to clarify whether steatosis and inflammation are more marked in areas with increased CB1 overexpression. For ethical and economic reasons, the present study investigated tissue from archived liver blocks, which were obtained from 38 rats t

Is there an exoplanet in the Solar system?

We investigate the prospects for the capture of the proposed Planet 9 from other stars in the Sun's birth cluster. Any capture scenario must satisfy three conditions: the encounter must be more distant than ∼150 au to avoid perturbing the Kuiper belt; the other star must have a wide-orbit planet (a ≳ 100 au); the planet must be captured on to an appropriate orbit to sculpt the orbital distribution

Common Susceptibility Loci for Male Breast Cancer

BackgroundThe etiology of male breast cancer (MBC) is poorly understood. In particular, the extent to which the genetic basis of MBC differs from female breast cancer (FBC) is unknown. A previous genome-wide association study of MBC identified 2 predisposition loci for the disease, both of which were also associated with risk of FBC.MethodsWe performed genome-wide single nucleotide polymorphism ge

Market driving at Bottom of the Pyramid (BoP) : An analysis of social enterprises from the healthcare sector

To date, scholarly understanding of external dimensions of market driving for the purposes of 'societal change' is largely unexplored in both developed and emerging market contexts. This paper uses a multiple case study approach to understand how market driving social enterprises (across the hybrid spectrum) create societal change in emerging markets. By drawing on Scott's (1995) three-part concep

Femtosecond time-resolved absorption spectroscopy of astaxanthin in solution and in alpha-crustacyanin

Steady-state absorption and femtosecond time-resolved spectroscopic studies have been carried out on astaxanthin dissolved in CS2, methanol, and acetonitrile, and in purified alpha-crustacyanin. The spectra of the S-0 -> S-2 and S-1 -> S-n transitions were found to be similarly dependent on solvent environment. The dynamics of the excited-state decay processes were analyzed with both single wavele

Engagemang i Lutherhjälpen : studier av motiv och drivkrafter hos frivilligt aktiva

Popular Abstract in Swedish Del 1. Introduktion I kapitel 1 presenteras arbetets problem, syfte och metod. Det arbete som olika frivilligorganisationer och deras medlemmar utför har de senaste åren uppmärksammats alltmer. Detta ökade intresse finner man såväl i Sverige som internationellt. Fokus i detta arbete riktas mot drivkrafterna bakom frivilligt engagemang. Det övergripande problemet är varfThis thesis focuses on the incitement to commitment and voluntary work. The overall problem is the question why you get involved in voluntary work for an organisation like Lutherhjälpen, the organisation for international development co-operation of the Church of Sweden, one of the largest NGOs of the country. The theoretical perspectives are seen from the position of the increasing pace of change

Resonance in the K2-19 system is at odds with its high reported eccentricities

K2-19 hosts a planetary system composed of two outer planets, b and c, with size of 7.0 ± 0.2 R⊕ and 4.1 ± 0.2 R⊕, and an inner planet, d, with a radius of 1.11 ± 0.05 R® A recent analysis of Transit-Timing Variations (TTVs) suggested b and c are close to but not in 3:2 mean motion resonance (MMR) because the classical resonant angles circulate. Such an architecture challenges our understanding of

Trajectory Optimization for Physics-Based Reconstruction of 3d Human Pose from Monocular Video

We focus on the task of estimating a physically plausi-ble articulated human motion from monocular video. Ex-isting approaches that do not consider physics often pro-duce temporally inconsistent output with motion artifacts, while state-of-the-art physics-based approaches have either been shown to work only in controlled laboratory conditions or consider simplified body-ground contact limited to f

Pragmatic Muslim Politics : The Case of Sri Lanka Muslim Congress

This book analyses and discusses the use of Islamic terms and symbols in the political party Sri Lanka Muslim Congress (SLMC). It is based on interviews with the leading members of the party and on analyses of the party’s official documents. It describes the history of Muslims in Sri Lanka, presents the analytical framework used, and discusses the official documents and narratives of party members