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During amino acid starvation the Escherichia coli stringent response factor RelA recognizes deacylated tRNA in the ribosomal A-site. This interaction activates RelA-mediated synthesis of alarmone nucleotides pppGpp and ppGpp, collectively referred to as (p)ppGpp. These two alarmones are synthesized by addition of a pyrophosphate moiety to the 3 position of the abundant cellular nucleotide GTP and
Purpose: When a child needs a hematopoietic stem cell transplant, the seriousness of the child's illness is highlighted. The purpose of this study was to explore parents' experiences of the transplantation process when two children in the family are involved, one severely ill child as the recipient and the other as the donor. Methods: In this qualitative study, interviews were conducted with 18 pa
This thesis concerns estimation in partially observed continuous and discrete time Markov models and focus on both inference about the conditional distribution of the unobserved process as well as parameter inference for the dynamics of the unobserved process. Paper A concerns calibration of advanced stock price models, in particular the Bates and NIG-CIR models, using options data observed th
The paper presents an analysis of context within which FAR, the Swedish professional association representing accountants has developed and revised the Code of Ethics from 1923 to 1995. The purpose is to enhance our understanding of the choices made as to what ethical rules were verbalized or codified and the motivations behind the codification. Building on Birkett and Evans’ (2005) model for orga
Public squares are everyday life-spaces, essential for supporting social interaction and thereby contributing to individuals’ wellbeing and quality of life. The provision of safe, accessible, and inclusive public squares is an imperative for sustainable urban development of cities and communities.After dark, electric lighting is necessary for sustaining activities, including social interaction, in
AbstractAim The aim of this thesis was to evaluate the treatment and follow-up of patients undergoing hypospadias surgery at the Department of Plastic and Reconstructive Surgery, Skåne University Hospital, Malmö, in an attempt to improve the overall care of these patients. It also aimed to investigate the tissue properties of the urethral plate and deep chordee in hypospadias patients with signifi
We previously reported that soluble decay-accelerating factor (DAF) and coxsackievirus-adenovirus receptor (CAR) blocked coxsackievirus 133 (CVB3) myocarditis in mice, but only soluble CAR blocked CVB3-mediated pancreatitis. Here, we report that the in vitro mechanisms of viral inhibition by these soluble receptors also differ. Soluble DAF inhibited virus infection through the formation of reversi
With advances in data acquisition and processing methods, spectral inversion of time domain (TD) induced polarization (IP) data is becoming more common. Geological interpretation of inverted spectral parameters, for instance Cole–Cole parameters, often relies on results from systematic laboratory measurements. These are most often carried out with frequency domain (FD) systems on sandstone samples
This paper tests the “Square Root Rule” (the SRR), a Basel sanctioned method of scaling 1-day Value At risk to higher time horizons. The SRR has come under serious assault from leading researchers focusing on its week theoretical basis: assuming i.i.d. asset returns. I performed an empirical test of the SRR on the 10-day horizon, the maximum horizon allowed by Basel, comparing SRR performance to d
Combination of right EGR rates with turbocharging has been identified as a promising way to increase the maximum load and efficiency of heavy duty spark-ignited natural gas engines. With stoichiometric conditions a three way catalyst can be used which means that regulated emissions can be kept at very low levels. However dilution limit is limited in these types of engines because of the lower burn
The focus of this study was exploring the product development process of a dairy- based drink which was co-created within a public-private partnership approach for Base of Pyramid (BoP) consumers in Zambia. An exploratory case-study research design was selected. Through interviews, documentation and observations, the steps of the product development process were mapped and the contributions from t
