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Aims: Iron deficiency (ID) is a common co-morbidity in heart failure (HF), associated with impaired functional capacity, poor quality of life and increased morbidity and mortality. Treatment with intravenous (i.v.) ferric carboxymaltose (FCM) has shown improvements in functional capacity, symptoms and quality of life in stable HF patients with reduced ejection fraction. The effect of i.v. iron sup
Hjärtsvikt betecknar ett syndrom som innebär att hjärtat har otillräcklig förmåga att försörja kroppen med blod. Detta kan antingen bero på att hjärtat inte kan fyllas med eller stöta ut tillräckligt med mängd blod. Patienter med hjärtsvikt har i allmänhet hög dödlighet, detta trots att stora framsteg har gjorts avseende behandlingen av hjärtsvikt, speciellt sedan 1980-talet. Femårsöverlevnaden föIntroduction: Despite major advances, the incidence rate and mortality of heart failure (HF) remains high, with a five-year survival of approximately 50%. At the time of inception of this thesis the familial risks of HF, including the aspects of mortality, were largely underdetermined. This thesis is composed of four papers with the main aims as follows:To determine the risk of hospitalization of
Background: Brief Admission is a crisis and risk management strategy in which self-harming and suicidal individuals with three or more diagnostic criteria of borderline personality disorder self-admit to hospital at times of increasing risk when other efforts to stay safe are failing. Standardized in the current randomized controlled trial, the intensity of Brief Admission Skåne is implemented in
Background: Survivors of childhood cancer are at increased risk for a wide range of late effects. However, no large population-based studies have included the whole range of somatic diagnoses including subgroup diagnoses and all main types of childhood cancers. Therefore, we aimed to provide the most detailed overview of the long-term risk of hospitalisation in survivors of childhood cancer. Metho
IMPORTANCE The clinical management of BRCA1 and BRCA2 mutation carriers requires accurate, prospective cancer risk estimates. OBJECTIVES To estimate age-specific risks of breast, ovarian, and contralateral breast cancer for mutation carriers and to evaluate risk modification by family cancer history and mutation location. DESIGN, SETTING, AND PARTICIPANTS Prospective cohort study of 6036 BRCA1 and
Serum levels of Anti-Mullerian Hormone (AMH) have been shown to be biomarker for prediction of the quantitative aspects of ovarian reserve. On the male side, sperm chromatin structure assay (SCSA) DNA fragmentation index (DFI) has been demonstrated to be an important predictor of outcomes in standard IVF procedures but to less degree in intracytoplasmic sperm injection procedures (ICSI). The purpo
Background: Little is known about accuracy of common risk prediction scores in elderly patients suffering from hip fractures. The objective of this study was to investigate accuracy of the Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity (POSSUM) score, Portsmouth-POSSUM (P-POSSUM) score and the Nottingham Hip Fracture Score (NHFS) for prediction of mortali
Pain, use of painkillers and alcohol are highly prevalent in the general population. Aims of the study were to describe differences in pain, alcohol consumption and use of painkillers among two 60 year old birth cohorts stratified by gender. Participants were recruited from the Skåne centre of The Swedish National study on Aging and Care, a multicentre, prospective, longitudinal study. The sample
Abstract Background: Advanced paediatric surgery is increasingly centralised in Sweden in order to improve treatment outcomes and reduce surgical risks. However, the overall need for surgery in the paediatric population has not been estimated, and the association between geographic access to surgical facilities and timely treatment for common surgical conditions in children is largely unknown.
The aim of the project MASTER (MAnaging Speeds of Traffic on European Roads) was to produce information that can be cited in the preparation of national and EU decisions concerning speed management and speed control equipment standards. For this purpose, the project looked for answers to three key questions: 1)What are acceptable ranges of speeds? 2)What are the key factors influencing drivers’ ch
Literature list Sustainability Science: The Field Development (MN) 1. Kates, Robert W., et al. (2001). Sustainability Science. Science 292(5517) (2 pages) 2. Clark, W. C. (Ed.). (2007). Sustainability science: A room of its own. Proceedings of the National Academy of Sciences (PNAS), 104(6), 1737-1738. (2 pages) 3. Spangenberg, J. H. (2011). Sustainability science: a review, an analysis and some e
https://www.lucsus.lu.se/sites/lucsus.lu.se/files/2024-01/PhD%20Course%20Literature%20List_25%20Jan.pdf - 2026-07-10
BioeconomyStakeholderConference_DK_170515.key Deniz Koca, Ph.D., Lund University, Centre for Environmental and Climate Research BIOECONOMY Graduate Research School deniz.koca@cec.lu.se http://www.cec.lu.se/bioeconomy Advancing the Transition to Bioeconomy: A Systems Approach Layout Background (What is bioeconomy? Do we all have a common vision?) Benefits and challenges of bioeconomy What is needed
https://www.hallbarhet.lu.se/sites/hallbarhet.lu.se/files/deniz_koca_15_maj_2017.pdf - 2026-07-10
Evidence for disease-regulated transgene expression in the brain with use of lentiviral vectors Evidence for Disease-Regulated Transgene Expression in the Brain With Use of Lentiviral Vectors Johan Jakobsson,1 Nina Rosenqvist,1 Karl Mårild,1 Denes v. Agoston,2 and Cecilia Lundberg1* 1Department of Experimental Medical Research, Section for Neuroscience, Wallenberg Neuroscience Centre, Lund Univer
Research School in Stem Cell Biology ANNUAL REPORT I 2020 2 QUOUSQUE TANDEM ABUTERE In brief The Research School in Stem Cell Biology is an academic consortium that focuses on excellence in research training and career development. We offer a diverse selection of educational activ- ities to provide the next generation of stem cell scientists with an excellent starting platform for a successful car
https://www.stemcellcenter.lu.se/sites/stemcellcenter.lu.se/files/annual_report_2020_rsscb.pdf - 2026-07-10
Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report https://doi.org/10.2337/dc18-2282 OBJECTIVE Assessment of the predictive power of TEDDY-identified risk factors for islet autoimmunity (IA), the type of autoantibody appearing first, and type 1 diabetes (T1D). RE
https://www.teddy.lu.se/sites/teddy.lu.se/files/105_mp221_krischer_diab_care_2019.pdf - 2026-07-10
Popular Abstract in Swedish Beräkningar från Cancerfonden visar på att ungefär var tredje person i Sverige kommer att få en cancerdiagnos under sin livstid. Cancerceller är celler som har utvecklat speciella förmågor som gör att de har börjat dela sig ohämmat. Denna ohämmade celldelning leder till bildandet av en tumör och när tumören har nått ett visst stadie i sin utveckling så börjar den spridaAs a cancer grows it will, at a certain stage of disease progression, start spreading in the body. For several types of cancer this spreading will first occur through the lymphatic system and the first place where metastatic cell will be encountered is the first lymph node that drains the area where the tumor is located. This lymph node is defined as the sentinel lymph node (SLN). By analyzing the
BACKGROUND AND OBJECTIVES: The treatment of acquired aplastic anemia (AA) is based on allogeneic bone marrow transplantation (BMT) and immunosuppressive therapy. The aim of this study was to assess the outcome of children and adults with AA treated in the last decade, and to determine whether results have improved in two sequential time periods,1991-1996 and 1997-2002. DESIGN AND METHODS: Two-thou
