Cell of Origin of Breast Cancer: An Updated Hypothesis Merging Epidemiological Data with Molecular Biology
Two different hypotheses about cell of origin of breast cancer have been proposed. One theory states that breast cancer originates from an epithelial stem cell and subsequent genetic changes determine the phenotype, while another hypothesis postulates that breast cancer could originate from different cells, both stem cells and progenitor cells. Therefore, the phenotype in the latter situation is p
