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Effects of Coumarins from Roots of Paramignya scandens (Griff.) Craib on LPS-induced IL-1β and IL-10 Cytokine Production in RAW 264.7 Macrophages

Based on our previous study, we evaluated the modulatory effects on LPS-induced IL-1β and IL-10 cytokine production in RAW 264.7 macrophages of several medicinal herbs, including P. scandens. The results showed that P. scandens extract showed significant effects on LPS-induced IL-1β and IL-10 cytokine production in RAW 264.7 macrophages. Therefore, in the current research, we focused on the P. sca

LOCALLY CONSERVATIVE AND FLUX CONSISTENT ITERATIVE METHODS

Conservation and consistency are fundamental properties of discretizations of conservation laws, necessary to ensure physically meaningful solutions. In the context of systems of nonlinear hyperbolic conservation laws, conservation and consistency additionally play an important role in convergence theory via the Lax-Wendroff theorem. Here, these concepts are extended to the realm of iterative meth

Diastolic Filling in Patients After Heart Transplantation Is Impaired Due to an Altered Geometrical Relationship Between the Left Atrium and Ventricle

BackgroundThe geometrical relationship between atrial and ventricular short‐axis cross‐sectional area determines the hydraulic forces acting on intracardiac blood. This is important for diastolic filling. In patients undergoing heart transplantation (HTx), the left atrium is often enlarged as a result of the standard surgical technique. We hypothesized that diastolic filling in HTx patients is aff

The influence of different ultrafiltration set-ups on the mineral partitioning between skim milk streams

In this study, the partitioning of minerals in ultrafiltration (UF) streams of skim milk using cross-flow (CF-UF) and dead-end (DE-UF) was investigated using 50 kDa membrane at different temperatures (5, 10, 25, 35, 55°C). CF-UF showed higher protein retention (6.02–10.9%) compared with DE-UF (3.44–4.70%), along with more retention of calcium, with values ranging from 29.8 to 41.5 and 57.8 to 112

Who changes what, when and where? Elaborating postponement when integrating hardware and software objects in global supply chains

Purpose: The postponement principle concerns defining when and where value is added, usually referring to hardware components for physical products. However, in modern supply chains, software’s importance is increasing, impacting the timing and location of value-adding operations. Lacking insights into software-driven implications for postponement, we aim at elaborating on the postponement princip

Swelling kinetics of mixtures of soybean phosphatidylcholine and glycerol dioleate

Lipid-based drug delivery systems offer the potential to enhance bioavailability, reduce dosing frequency, and improve patient adherence. In aqueous environment, initially dry lipid depots take up water and form liquid crystalline phases. Variation of lipid composition, depot size and hydration-induced phase transitions will plausibly affect the diffusion in and out of the depot. Lipid depots of s

Journal of European Public Policy Virtual Special Issue on Normative Power

The social sciences have many different understandings of ‘normative power’, but in European Union (EU) studies normative power has three particular meanings. The first meaning of normative power is its emphasis on normative theory, that is, how we judge and justify truth claims in social science. The second meaning of normative power is as a form of power that is ideational rather than material o

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Abstract in SpanishEn este artículo se propone un acercamiento didáctico a la enseñanza del Pretérito Perfecto Compuesto (PPC) en contextos de español como lengua extranjera. Se analizan algunos problemas de la visión tradicional sobre el tema y se plantea que el concepto de referencia genérica propuesto en Henderson (2010) da una respuesta más coherente a usos que la bibliografía suele adjudicar This article proposes a didactic approach to teaching the compound past tense that is known in English as “Present Perfect” (PPC for its initials in Spanish) in contexts of Spanish as a Foreign Language. It analyses some issues concerning the traditional view on the subject and suggests that the concept of generic reference proposed by Henderson (2010) provides a more coherent explanation for some

Normative power Europe reconsidered : beyond the crossroads

The idea of being civilian, military, and civilizing at the same time is undoubtedly very seductive to the armies of academics now writing on EU military force. It is tempting to think that the EU can have-its-cake-and-eat-it-too in militarizing its normative power. In contrast, in my reconsideration of normative power Europe I suggest that militarization of the EU need not necessarily lead to the

An Act of Balance : Exploring the Boundaries of Librarianship in Times of Political Turmoil in Sweden and Denmark

This paper presents an analysis of how library professionals in Sweden and Denmark perceive the democratic role of the library profession in the polarised political landscape of today. Relating to research on the democratic role of libraries, professional ethics and cultural policies, empirical data was gathered through seven group interviews with library professionals from eleven local libraries

Design and evaluation of non-planar material extrusion on A3-axis printer

The use of material extrusion (MEX) has increased rapidly due to the affordability of 3D printers. This has led to a growing demand for improved print quality, high fidelity, strength, or fast print times. In this study, a non-planar approach for better surface quality is investigated. The hardware of a 3-axis MEX printer was developed together with testing new software for non-planar slicing. The

Enabling patient-physician continuity in Swedish primary care : the importance of a named GP

BACKGROUND: Continuity of care is important for patients with chronic conditions. Assigning patients to a named GP may increase continuity.AIM: To examine if patients who were registered with a named GP at the onset of their first chronic disease had higher continuity at subsequent visits than patients who were only registered at a practice.DESIGN & SETTING: Registry-based observational study

Electrophysiological Evidence for a Whorfian Double Dissociation of Categorical Perception Across Two Languages

Taza in Spanish refers to cups and mugs in English, whereas glass refers to different glass types in Spanish: copa and vaso. It is still unclear whether such categorical distinctions induce early perceptual differences in speakers of different languages. In this study, for the first time, we report symmetrical effects of terminology on preattentive indices of categorical perception across language

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A workshop and gallery space that hosts artists and local in co-creative processes.

Large-Eddy Simulation of Supersonic Combustion in a Mach 2 Cavity-Based Model Scramjet Combustor

In this study we report on reactive Large Eddy Simulations (LES) of flow and combustion in the US Air Force Research Laboratory Research Cell 19 cavity-based scramjet combustor. This case involves combustion of ethylene that is injected into a cavity. It has previously been studied experimentally with multiple techniques as well as numerically using hybrid RANS/LES. Here, we build on the existing

Real-World Treatment Patterns and Survival Outcomes for Patients with Non-Metastatic Non-Small-Cell Lung Cancer in Sweden : A Nationwide Registry Analysis from the I-O Optimise Initiative

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, with ~40–50% of patients diagnosed with non-metastatic disease (stages IA–IIIC). The treatment landscape is evolving rapidly as immunotherapies and targeted therapy are introduced in the non-metastatic setting, creating a need to assess patient outcomes prior to their introduction. This real-world study usin

Intracranial Atherosclerosis in Medieval Scandinavia

In past human populations, atherosclerosis has been identified in mummies from different regions of the world, and from a range of chronological periods (for extensive reviews see Chapters 3 and 4). This current study from Sweden aims to contribute to the limited evidence for atherosclerosis associated with human skeletal remains by presenting examples of atherosclerosis in another part of the bod