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The transcriptional factor SOX11 is a disease-defining antigen in mantle cell lymphoma (MCL) and absent in most non-malignant tissues. To explore the role of SOX11-related cell signaling, and potentially take benefit from these for targeted therapy, associated networks and proteins need to be defined. In this study, we used an inducible SOX11 knock-down system followed by gene expression analysis
Objectives To validate the two recently developed disease activity indexes for assessment of primary Sjogren's syndrome (SS): the European League Against Rheumatism (EULAR) SS Patient Reported Index (ESSPRI) and the EULAR SS Disease Activity Index (ESSDAI). Methods A prospective international 6-month duration validation study was conducted in 15 countries. At each visit, physicians completed ESSDA
In this study we investigated the intricate interplay between central linguistic processing and peripheral motor processes during typewriting. Participants had to typewrite two-constituent (noun-noun) Finnish compounds in response to picture presentation while their typing behavior was registered. As dependent measures we used writing onset time to assess what processes were completed before writi
There is a general trend that parasitism risk declines as latitude increases. Host populations breeding at high latitudes should therefore invest less in costly immune defenses than populations breeding in temperate or tropical zones, although it is unknown if such an effect is mediated by environmental (photoperiodic) or genetic factors or both. Acquired immune function (humoral, cell-mediated) a
The standard approach in computer-controlled systems is to sample and control periodically. In certain applications, such as networked control systems orenergy-constrained systems, it could be advantageous to instead use event-based control schemes. Aperiodic event-based control of first-order stochastic systems has been investigated in previous work. In any real implementation, however, it is nec
In the Eastern Alps (Austria) several marine successions, which were deposited ranging from shallow shelf to bathyal slope and abyssal basin, provide detailed records across the Paleocene/Eocene-boundary. These records indicate a two-step event starting with a prominent sea-level fall and followed by climatic changes. At the northern and southern shelves that fringed the Penninic Basin, the shallo
Lifestyle changes such as caloric over-consumption and decreased physical activity are causing overweight and obesity, leading to an epidemic increase in type 2 diabetes mellitus (T2DM). Overweight, cardiovascular disease and diabetes are closely linked, and cardio-vascular disease is the most important cause of morbidity and mortality among patients with T2DM. Identifying food that can reduce blo
This study analyses the development of the Lao freight logistics sector with a special focus on factors influencing freight logistics services efficiency after the processes of liberalization and deregulation of the economy. Based on empirical data, the study focuses on two main dimensions of the Lao freight logistics sector: (i) the development of a private freight logistics sector since the form
Enterococcus faecalis exhibits high resistance to oxidative stress. Several enzymes are responsible for this trait. The role of alkyl hydroperoxide reductase (Ahp), thiol peroxidase (Tpx), and NADH peroxidase (Npr) in oxidative stress defense was recently characterized. Enterococcus faecalis, in contrast to many other streptococci, contains a catalase (KatA), but this enzyme can only be formed whe
Assessment of costs accompanying activation of immune system and related neuroendocrine pathways is essential for understanding the selective forces operating on these systems. Here we attempted to detect such costs in terms of disruption to redox balance and interference between different immune system components in captive wild-caught greenfinches (Carduelis chloris). Study birds were subjected
This thesis presents methods for improving machining with industrial robots using control, with focus on increasing positioning accuracy and controlling feed rate. The strong process forces arising during high-speed machining operations, combined with the limited stiffness of industrial robots, have hampered the usage of industrial robots in high-end machining tasks. However, since such manipulato
I denna artikel studeras metaforer i den svenska civilrätten med hjälp av en modern teori om metaforer – den kognitiva lingvistiken och dess undergrupp, den konceptuella metaforteorin. Syftet är att göra observationer av konceptuella metaforer och visa på metaforerna och deras underliggande tankestrukturers grundläggande betydelse för civilrättslig reglering, och vi använder oss därför av flera ex
Popular Abstract in Swedish Luftföroreningar har i många studier visat sig skada vår hälsa. Även om risken för den enskilda individen kan vara relativt liten så kan omfattningen av hälsoeffekterna bli stora eftersom det är så många som exponeras. Tidigare har man huvudsakligen sett effekter på andningsorganen men under de senare åren har man även börjat se effekter som sträcker sig bortom våra andWe had in the present thesis the unique possibility to use, in a socio-economically relatively homogenous population, high quality registry information on a population-based birth cohort (84 039 births during the period 1999-2005) in Scania (Skåne), the most Southern county of Sweden. The aim of the thesis was to investigate whether exposure to air pollution, in an area of low-levels exposures, du
Frontotemporal dementia (FTD) is associated with a broad spectrum of clinical characteristics. The objective of this study was to analyze the prevalence of unexplained somatic complaints in neuropathologically verified FTD. We also examined whether the somatic presentations correlated with protein pathology or regional brain pathology and if the patients with these somatic features showed more dep
This paper analyzes the impact of intermarriage on the economic integration of immigrants in Sweden, measured by annual earnings. We use longitudinal register data for the period 1990-2009 for the total population of immigrant men born 1960-1974. The results reveal large intermarriage premiums, but overall this seems to be a result of selection effects as most of the premium is visible already at
