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In this thesis, genetic alterations in bone and soft tissue tumors have been investigated with the purpose of identifying regions of importance for tumor development, diagnosis and prognosis. This has primarily been performed by array comparative genomic hybridization analysis and gene expression profiling of cytogenetically analyzed tumors. In Article I, the content of ring chromosomes in a subse
En ockult våg svepte fram över Europa kring förra sekelskiftet. Poeten W.B. Yeats var, liksom den store auktoriteten på Tarot-kort A.E. Waite, medlemmar av the Golden Dawn, en sluten ockult frimurarorden, som hade grundats i London 1887 och som hade ett både sociokulturellt och litterärt inflytande i speciellt England och USA, men också på kontinenten. Sin inspiration hämtade Golden Dawn från renä
Many mossy fiber pathways to the neurons of the deep cerebellar nucleus (DCN) originate from the spinal motor circuitry. For cutaneously activated spinal neurons, the receptive field is a tag indicating the specific motor function the spinal neuron has. Similarly, the climbing fiber receptive field of the DCN neuron reflects the specific motor output function of the DCN neuron. To explore the rela
A review of the two last volumes of Martin Schwarz Lausten's six volume study on Church and Jewry in Denmark.
Context. Metal-rich globular clusters provide important tracers of the formation of our Galaxy. Moreover, and not less important, they are very important calibrators for the derivation of properties of extra-galactic metal-rich stellar populations. Nonetheless, only a few of the metal-rich globular clusters in the Milky Way have been studied using high-resolution stellar spectra to derive elementa
Maria Nyman The Borders of travelling. Russia in Swedish travel accounts during the 18th century. The primary objective of this study concerns how culturally created images of the Same and the Other, is expressed in descriptions of a journey, a sojourn someplace else. More specifically, the dissertation investigates how a number of Swedes, travelling during the eighteenth- and early nineteenth cen
Estimates of relevant source area of pollen (RSAP) and relative pollen productivity (PPE) are critical parameters for quantitative reconstructions of past vegetation and land cover. This study provides estimates for PPE relative to Poaceae for ten taxa, characterizing the cultural landscape of south Estonia and the RSAP for 40 lakes with an average radius of approximately 100 m (22-274 m, average
Since knowability must emanate from the single individual, singularity constitutes the frame of reference, and the embodiment of knowing is expected to emerge through individual text production. Furthermore, the basis of the presented studies will consist of text materials with unknown frame factors. This is especially underlined by the fact that history at the Times of Tacitus was an art, not a s
Background: Global ischemic stroke is one of the most prominent consequences of cardiac arrest, since the diminished blood flow to the brain results in cell damage and sometimes permanently impaired neurological function. The post-arrest period is often characterised by cerebral hypoperfusion due to subacute hemodynamic disturbances, the pathophysiology of which are poorly understood. In two other
Popular Abstract in Swedish Blod består av flera olika typer av mogna celler som har specialiserat sig på olika uppgifter, till exempel transporterar röda blodkroppar, erytrocyter, syre, medan lymfoida celler, sk B och T-celler är en del av vårt immunförsvar. Alla dessa mogna celler kan bildas från en cell, nämligen den hematopoietiska stamcellen. Stamcellens dotterceller utvecklas sedan till mer All hematopoietic cells originate from hematopoietic stem cells (HSCs) residing in the bone marrow (BM). The classical model of hematopoietic lineage commitment, that has been the prevailing model for hematopoiesis, proposes that the first lineage commitment step of HSCs and progenitors results in a strict separation of myelopoiesis and lymphopoiesis. However, an alternative model has already been
Insulin secretion from pancreatic beta cells is a fundamental physiological process, and its impairment plays a pivotal role in the development of diabetes. Mathematical modeling of insulin secretion has a long history, both on the level of the entire body and on the cellular and subcellular scale. However, little direct communication between these disparate scales has been included in mathematica
Although Moraxella catarrhalis and Neisseria meningitidis are important human pathogens, they often colonize the human respiratory tract without causing overt clinical symptoms. Both pathogens express structurally unrelated proteins that share the ability to stimulate the adhesion molecule CEACAM1 expressed on human cells. Here we demonstrate that the interaction of CEACAM1 with ubiquitous surface
Purpose – The performance of service supply chains in terms of service levels and cost efficiency depends not only on the effort of service providers but also on the inputs of sub-contractors and the customer. In this sense, performance-based contracting (PBC) entails increased financial risk for providers. Allocating and managing risk through contractual relationships along the service supply cha
Multiconfigurational SCF and second-order perturbation theory have been employed to study seven low-lying singlet and triplet electronic states of the Mo-2 molecule. The bond order of the ground state has been analyzed based on the effective bond order (EBO), indicating that a fully developed sextuple bond is formed between the two Mo atoms. The experimentally observed excited states a(3)Sigma(+)(
Serotonin, a highly pro-inflammatory molecule released by activated platelets, is formed by tryptophan. Tryptophan is also needed in the production of kynurenine, a process mediated by the type I interferon (IFN)-regulated rate-limiting enzyme indoleamine 2,3-dioxygenase (IDO). The aim of this study was to investigate levels of serotonin in patients with the autoimmune disease systemic lupus eryth
Despite evidence that both pollinators and nonpollinator agents of selection can shape the evolution of floral characters, there have been few attempts to compare the strengths and directions of selection from pollinators and other agents in the same study system. In this investigation of Leucanthemum vulgare, a self-incompatible composite known for its conspicuous white rays, I obtained data from
In March 2011 the Supreme Court issued its Prometheus opinion and granted certiorari, and reversed and remanded Myriad I for consideration in light of Prometheus. In August 2012 the Myriad II decision was issued. The panel in Myriad II repeated most of their separate Myriad I opinions. Myriad deja vu looked much like Myriad I with panel members agreeing that Prometheus did not control the composit
Background and purpose The Charnley Elite-Plus stem was introduced in 1993 as a presumed improvement of the flanged Charnley stem. We started this study in 1996 to investigate the migratory pattern of the Elite-Plus stem. Patients and methods We followed 114 patients with osteoarthritis and a primary total hip replacement with the Elite-Plus stem. Mean age at the time of operation was 64 (50-76) y
Popular Abstract in Swedish Inom forskningsområdet biogeokemi studerar man hur naturens olika grundämnen, såsom kol, kväve, fosfor och kisel ändrar form och transporteras genom landskapet för att via bäckar och vattendrag till slut nå havet. Tillsammans beskriver dessa olika processer, som sker på olika tidsskalor, från sekunder till flera miljoner år, ett grundämnes kretslopp (eller biogeokemiskaSilicon is the next most abundant element in the Earth’s crust and its biogeochemical cycle is linked with that of carbon. Further, silicon is a beneficial nutrient for plants in terrestrial ecosystems and a key nutrient for diatoms in aquatic ecosystems. During the last decade the important role of terrestrial vegetation in controlling Si fluxes downstream aquatic environments, via incorporation
We investigate four different methods for background estimation in calcium imaging of the insect brain and evaluate their performance on six data sets consisting of data recorded from two sites in two species of moths. The calcium fluorescence decay curve outside the potential response is estimated using either a low-pass filter or constant, linear or polynomial regression, and is subsequently use
