Sökresultat

Kruppel-like factor 11 is a pancreatic transcription factor whose activity induces the insulin gene. A common glutamine-to-arginine change at codon 62 (Q62R) in its gene KLF11 has been recently associated with type 2 diabetes in two independent samples. Q62R and two other rare missense variants (A347S and T220M) were also shown to affect the function of KLF11 in vitro, and insulin levels were lowe

The location of the red edge of the ZZ Ceti instability strip is definedobservationally as being the lowest temperature for which a white dwarfwith a H-rich atmosphere (DA) is known to exhibit periodic brightnessvariations. Whether this cut-off in flux variations is actually due to acessation of pulsation or merely due to the attenuation of anyvariations by the convection zone, rendering them invi

Caveolin- 1 ( Cav- 1) is essential for the morphology of membrane caveolae and exerts a negative influence on a number of signaling systems, including nitric oxide ( NO) production and activity of the MAP kinase cascade. In the vascular system, ablation of caveolin- 1 may thus be expected to cause arterial dilatation and increased vessel wall mass ( remodeling). This was tested in Cav- 1 knockout

The choice of proper insulation for cold protection is important. However, “proper insulation” depends on activity and at lots of jobs the activity varies along the working day. The choice of low insulation for high metabolic rate makes people feel cold during low activity levels and the choice of high insulation for low metabolic rate makes them feel hot and sweat during high activity levels. The

Abstract in French Cet article est basé sur l’analyse de deux corpus de français écrit langue étrangère par des apprenants suédois ; l’un transversal et l’autre longitudinal. Les deux corpus permettent des approches différentes, l’une de caractère linguistique mettant l’accent sur le profil développemental de l’accord en nombre ; l’autre plus cognitive analysant les aspects des connaissances expliThis article is based on an analysis of two corpora in French as a foreign language by Swedish learners; one cross-sectional and the other longitudinal. These two corpora lent themselves to different approaches: a linguistic approach which stressed the developmental profile of agreement in number; and a more cognitive approach which analyzed various aspects of explicit and implicit knowledge in th

Essäns syfte är att med exempel ur olika texter ringa in några historiska, kulturella och existentiella aspekter av begreppet fotvandring.

We recently refined the in vitro motility assay for studies of actomyosin function to achieve rectified myosin induced sliding of actin filaments. This paves the way, both for detailed functional studies of actomyosin and for nanotechnological applications. In the latter applications it would be desirable to use actin filaments for transportation of cargoes (e.g., enzymes) between different predet

Planning management activities for a long-term sustainable forestry requires predictive tools designed for this kind of management. Many tools available today are either designed for planning periods that are too short to consider long-term sustainability, omit important parts of the forest ecosystem or are not capable of considering environmental changes. A long-term potential growth-limiting fac

Discussions about values are common in many contexts. Often, what is debated is the choice of means to realize or protect various values, but sometimes the discussion concerns the very values that ought to be realized or protected. Philosophical debate in this area has mainly been focused on two kinds of issues. Philosophers have tried to identify the set of fundamental values, i.e., to provide wh

Abstract is not available

Noninvasive methods for detecting cerebral artery vasospasm, still a serious complication following aneurysmal subarachnoid haemorrhage, are of vital interest. Up-to-date transcranial Doppler ultrasound (TCD) has proved to be sensitive in detecting vasospasm in the middle cerebral artery, but has less accuracy for other cerebral arteries. Transcranial cerebral oximetry (TCCO) is a new non-invasive

The Kaposi's, sarcoma-associated herpesvirus (KSHV) complement control protein (KCP) inhibits the human complement system, and is similar in structure and function to endogenous complement inhibitors. Other inhibitors such as C4d-binding protein and factor H, as well as the viral homologue vaccinia virus complement control protein are known to bind heparin and, for the two latter, also to glycosam

Background: beta(2)-Agonists may exert mast cell stabilizing and anti-plasma exudation effects. White available data suggest no or only marginal effects of beta(2)-agonists on symptoms of allergic rhinitis, little is known about whether these drugs may add to the efficacy of anti-rhinitis drugs. Objective: To examine effects of a beta(2)-agonist, alone and in combination with an intranasal glucoco

Popular Abstract in Swedish Elektroencefalogrammet (EEG), dvs mätning av potentialer på skalpen, är en relativt enkel och gammal teknik för att studera hjärnans aktivitet. Trots de stora framstegen inom s k brain-mapping-tekniker på senare år (magnetröntgen, PET, SPECT), är EEG fortfarande ett viktigt verktyg för diagnos. En av dess fördelar gentemot andra tekniker är dess fina tidsupplösning. EtThe thesis treats methods for pattern recognition in multichannel electroencephalogram (EEG) signals, for application to diagnostics of epilepsy. Parts I-IV treat methods for feature extraction and clustering of EEG spikes, occurring between epileptic seizures, and part V presents a method for filtering seizure onset EEG signals. In part I, Hermite functions are used for parametric description of