MYH9-related platelet disorders are inherited macrothrombocytopenias with additional clinical manifestations including renal failure, hearing loss, pre-senile cataract, and inclusion bodies in leucocytes that are present in different combinations. The MYH9 gene codes for the cytoplasmic contractile protein non-muscular myosin heavy chain IIA, present in several tissues. The bleeding tendency is us

A new type of chip based microelectrode for acute electrophysiological recordings in the CNS has been developed. It's designed to be adaptable to a multitude of specific neuronal environments, in this study the cerebellar cortex of rat and cat. Photolithographically patternened SU-8 is used to yield flexible and biocompatible penetrating shanks with gold leads. Electrodes with an impedance of abou

Popular Abstract in Swedish I denna avhandling presenteras olika studier om röstimitation. Det unika i den individuella rösten och om det är möjligt att förändra sin röst så att man blir till förväxling lik någon annan vad gäller rösten och talet diskuteras. Syftet med studierna var i första hand att ta reda på hur och i vilken omfattning en imitatör förändrar sin egen röst och sitt tal för att blThis thesis is about voice imitations, more specifically impersonation. Questions are raised about the uniqueness of a person’s voice and speech behaviour and if it is possible to get close to another speaker’s voice and speech. Four main research questions are investigated in different studies. The studies focus mainly on how close the imitation is to the target speaker, and addresses to a lesser

Retinitis Pigmentosa involves a hereditary degeneration of photoreceptors by as yet unresolved mechanisms. The secretable protein α-Klotho has a function related to ageing processes, and α-Klotho deficient mice have reduced lifespan and declining functions in several tissues. Here, we studied Klotho in connection with inherited photoreceptor degeneration. Increased nuclear immunostaining for α-Klo

Dopamine (DA) replacement therapy with l-DOPA remains the most effective treatment for Parkinson's disease, but causes dyskinesia (abnormal involuntary movements) in the vast majority of the patients. The basic mechanisms of l-DOPA-induced dyskinesia (LID) have become the object of intense research focusing on neurochemical and molecular adaptations in the striatum. Here we review this vast litera

Two constructions of binary concatenated convolutional codes are considered. In our previous work [Proc. 4th Int. Symp. Commun. Theory Appl., Lake District, UK (1997)] such codes were called woven convolutional codes. In the present paper, asymptotic lower bounds on active distances of woven convolutional codes are investigated. It is shown that these distances can be bounded from below by linearl