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Vasopressin and oxytocin in normal reproduction and in the patophysiology of preterm labour and primary dysmenorrhoea. Development of receptor antagonists for therapeutic use in these conditions.

Vasopressin and oxytocin are synthesised in the hypothalamus and released to the blood stream via the posterior lobe of the hypophysis. Research during later years has shown that these peptides are also produced in other parts of the brain. The secretion to plasma is stimulated by oestrogen, an effect which is counteracted by progestagen. During delivery the fetus can also produce substantial amou

The dasyscyphins A similar to C and niveulone, new biologically active compounds from the ascomycete Dasyscyphus niveus

In the course of a screening for cytotoxic Compounds from fungi four new terpenoid metabolites, named dasyscyphins A, B, C, and niveulone were isolated from fermentations of Dasyscyphus niveus strain A0101. While dasyscyphin A (1) exhibited no significant biological activities in our test systems dasyscyphin B (2) and dasyscyphin C (3) showed cytotoxic activities against human (HepG2, Hela S3, U93

Timing the doxycycline yields different patterns of genomic recombination in brain neurons with a new inducible Cre transgene.

We have developed a transgenic mouse expressing the Cre recombinase under control of a tetracycline-responsive promoter. Using a CamKIIalpha-driven tTA transgenic strain and a lacZ reporter mouse, we obtained the expected neuronal pattern of recombination in the olfactory lobe, cortex, striatum, hippocampus and Purkinje cells. Moreover, recombination can be completely abolished by feeding the mice

Development of the assessment framework for sustainability networking

This paper is concerned with question of how to assess results of networking which is an important element in movement towards sustainable development. Although based upon a large body of research, including empirical studies, the question of assessment of the networking results remains un-addressed, to a large extent. Based on an in-depth analysis of two Swedish tourism networks for sustainabilit

A new business model for baby prams based on easing and product remanufacturing

A shift in business thinking from selling products to providing service solutions to customer needs is becoming noticeable. It is driven by increasing competition and the need to identify new profit centres for producers of mature products. This paper identifies a new product group that could be interesting from the product-service system perspective - baby prams. The study presents a new business

Bridging-type changes facilitate successive oxidation steps at about 1 V in two binuclear manganese complexes - implications for photosynthetic water-oxidation

The redox behavior of two synthetic manganese complexes illustrates a mechanistic aspect of importance for light-driven water oxidation in Photosystem 11 (PSII) and design of biomimetic systems (artificial photosynthesis). The coupling between changes in oxidation state and structural changes was investigated for two binuclear manganese complexes (1 and 2), which differ in the set of first sphere

On permutor designs based on cycles for serially concatenated convolutional codes

A new permutor design for serially concatenated convolutional codes is presented. It is based on the construction of a permutation matrix without short cycles of special types. For such a permutor, we give a lower bound on the minimum distance of the overall code that is significantly larger than that achievable with first-order separation (spreading factors). Additionally, the minimum distance ca

Temperature-induced phase partitioning of peptides in water solutions of ethylene oxide and propylene oxide random copolymers

A thermoseparating random copolymer (Ucon 50-HB-5100) composed of (50%) ethylene oxide and (50%) propylene oxide has been used to form an aqueous two-phase system by heating the polymer-water solution above the cloud point of the copolymer. In the formed two-phase system a water rich top phase is in equilibrium with an aqueous polymer rich bottom phase. The partitioning of amino acids and peptides

Structural basis of glycosaminoglycan modification and of heterotypic interactions of perlecan domain V

The C-terminal perlecan domain V of about 90 kDa consists of laminin-type G domain modules (LG) (25 kDa) and epidermal growth factor-like modules (EG) (4 kDa) in the tandem arrangement LG1-EG1-EG2-LG2-EG3-EG4-LG3. Several shorter fragments have been prepared by recombinant production in mammalian cells and used to map the single glycosaminoglycan (GAG) substitution site and the binding of several

Achieving balance in everyday life: Insights from women with stress-related disorders.

There is growing interest in developing a conceptual understanding of the experience of balance in everyday life, from an occupational perspective. The purpose of this study was to gain insights about balance in the everyday lives of women with stress-related disorders. Data were gathered from 19 women who were past the first phase of recovery from a stress-related disorder and participated in one

A model for stochastic drift in memory strength to account for judgments of learning

Previous research has shown that judgments of learning (JOLs) made immediately after encoding have a low correlation with actual cued-recall performance, whereas the correlation is high for delayed,judgments. In this article, the authors propose a formal theory describing the stochastic drift of memory strength over the retention interval to account for the delayed-JOL effect. This is done by firs

BlueBellMouse. A Tool for Kinetic Model Development

Popular Abstract in Swedish För att kunna simulera de fysikaliska fenomen som pågår i förbränning, krävs även en beskrivning av den kinetik som ingår i förbränningsprocessen. För detta ändamål utvecklas kinetiska modeller. En kinetisk modell är en lista med kemiska reaktioner och reaktionshastighetsparametrar. Modellernas tillämpningsområde begränsas av de valideringsfall och de fysikaliska parameThe simulation of physical phenomena occurring in chemical reactors requires the description of the kinetics involved in the underlying combustion process. Kinetic models are developed for this purpose. A software package, BlueBellMouse, has been developed to facilitate a deeper automatization and ease of simulation, reduction and optimization of kinetic models. A kinetic model is made of a list o

Supersymmetry and models for two kinds of interacting particles

We show that Calogero-Sutherland models for interacting particles have a natural supersymmetric extension. For the construction, we use Jacobians that appear in certain superspaces. Some of the resulting Hamiltonians have a direct interpretation as models for two kinds of interacting particles. One model may serve to describe interacting electrons in a lower and upper band of a one-dimensional sem