Popular Abstract in Swedish Astma är en sjukdom som karakteriseras av upprepade anfall av andningssvårigheter, orsakade av kramp, slemhinnesvullnad och segt sekret i luftvägarna. Den finns beskriven i texter redan från det antika Grekland och rapporteras idag vara en sjukdom med utbredning över hela vårt klot. Astma är den vanligaste kroniska sjukdomen bland barn och är oavsett ålder den vanligastAsthma is a chronic disorder of the lower airways, characterized by inflammation and hyperreactivity. Pro-inflammatory cytokines like tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) are known to play important roles in the pathogenesis, but our knowledge how these cytokines contribute to the development of airway hyperreactivity is limited. The aims of the present study

The influence of predatory fish on the structure of stream food webs may be altered by the presence of forest canopy cover, and consequent differences in allochthonous inputs and primary production. Eight sites containing introduced brown trout (Salmo trutta) and eight sites that did not were sampled in the Cass region, South Island, New Zealand. For each predator category, half the sites were loc

The critical role of polyamines in key processes such as cell growth, differentiation and macromolecular synthesis makes the enzymes involved in their synthesis potential targets in the treatment of certain types of cancer and parasitic diseases. Here we present a study on the inhibition of human and Leishmania donovani ODC (ornithine decarboxylase), the first committed enzyme in the polyamine bio

The results of a preliminary investigation into the theoretical evaluation and study of the relationship between some room acoustical descriptors used for the subjective assessment of performance halls are considered. The concern is about three parameters, namely, the inter-aural cross-correlation coefficient (IACC), the early lateral energy fraction (ELEF) or a related measure, the spaciousness S

The congenital disorders of glycosylation (CDG) are a rapidly expanding group of metabolic syndromes with a wide symptomatology and severity. They all stem from deficient N-glycosylation of proteins. To date the group contains 18 different subtypes: 12 of Type I (disrupted synthesis of the lipid-linked oligosaccharide precursor) and 6 of Type II (malfunctioning trimming/processing of the protein-b

The scaling of results from combustion experiments with four organic substances containing heteroatoms, carried out on four different scales, is discussed. The scales ranged from the micro-scale, using about 2 x 10(-3) kg of the substances, to large scale using about 50 kg of the substances. The content of O-2, CO, CO2, NOx, HCl, HCN and SO2 in the combustion gases were determined with special att

The study of developmental language disorders is discussed from an interdisciplinary perspective. It is argued that retrospective studies have provided valuable information on developmental language disorders that needs to be integrated into a theoretical model capable of capturing the basic mechanisms of language development. Conclusion: It is concluded that interdisciplinary and prospective stud

BACKGROUND: Trimellitic anhydride (TMA) is a low molecular weight chemical that may cause occupational asthma in human beings. The objectives of this study were to determine the time course of immune and airway responses to TMA in guinea pigs and to relate the immunologic response to the immediate responses in lung resistance (RL) and plasma exudation induced by allergen challenge. METHODS: We stu

Popular Abstract in Swedish Ämnen i bröstmjölk kan få cancerceller att begå självmord - in vivo effekter och mekanismer för celldöd Sedan länge är det känt att bröstmjölk skyddar det ammande barnet mot infektioner och hjälper till att bygga upp des's immunförsvar. Ett skyddande ämne som kan bilda's av molekyler från bröstmjölk är HAMLET (human alpha-lactalbumin made lethal to tumor cell's), som kHAMLET (human alpha-lactalbumin made lethal to tumor cells), a molecular complex derived from human milk, is an interesting new tool in cancer research since it induces programmed cell death in tumor cells while leaving normal, differentiated cells unharmed. The in vivo effects of HAMLET were studied in a rat xenograft model of human glioblastoma. HAMLET reduced the tumor volume and delayed the o

In type I diabetes mellitus (T1DM), the frequency of antibodies against insulin (IAA), glutamic acid decarboxylase-65 (GAD65), ICA512/IA2 (IA2), and islet cell antigens (ICA) vary with human leukocyte antigen (HLA) composition of the patient. IAA, IA2 autoantibodies, and ICA are increased in DQ8 positives; GAD65 antibodies are increased in DQ2 positives. MHC class I chain-related gene-A (MICA) is

In this paper, the accuracy of dye tracer concentration estimations using image analysis is examined. The variability before and after application of different image correction methods was investigated in three experiments using a digital camera. In each of these experiments, one correction was applied and the remaining variability after correction was calculated as the SD of uniformly colored pat

The aim of this paper is to analyse the role that the Japanese Government has played in the development of alternatives to conventional vehicles, the effect of government programmes, and the importance of technical flexibility in government support schemes. The focus is on battery-powered electric vehicles (BPEVs), hybrid electric vehicles (HEVs), and fuel cell electric vehicles. The effects of go

In a previous study, we showed that diabetic patients exhibited significantly increased concentrations of total plasma homocysteine (tHcy), but not until the onset of nephropathy. It was suggested that the hyperhomocysteinaemia might contribute to the accelerated atherosclerotic process in diabetic patients. In the present study, we have analysed the main determinants of plasma homocysteine (i.e.

Li insertion into a thin anatase TiO2 film is studied for the first time in an ultra-high vacuum (UHV) environment. Using synchrotron radiation photoelectron spectroscopy, we demonstrate that the evaporated Li is inserted into the anatase and that the maximum amount that can be dissolved is 0.41 Li/Ti. Two most important properties are found in the UHV insertion process that can be directly relate