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An implicit formulation of the Bodner-Partom constitutive equations

The framework for an implicit implementation of the Bodner-Partom material model is presented. All equations needed for using a Newton-Raphson algorithm to solve the stress and hardening equations at the integration points are derived. In addition, the algorithmic tangential stiffness tensor, ensuring quadratic convergence in the global loop is presented.

Proteomics - the protein expression technology to study connective tissue biology

During the formation of peribronchial fibrosis in asthma, remodeling of connective tissue is due to an increase in deposition of extracellular matrix components like that of specific types of collagens and proteoglycans. By taking bronchial biopsies, we were able to isolate cell cultures derived from asthmatic patients and healthy volunteers, which provides a good model system to study differences

Multi-level analysis of alcohol-related injury among emergency department patients: a cross-national study

AIM: The aim of this analysis was to examine the average rate and variation of alcohol-related injury across emergency department (ED) studies, the effect of usual drinking on likelihood of alcohol-related injury, whether cross-study variation in rate of alcohol-related injury can be explained by between-study difference in usual consumption and whether social-cultural contextual variables help ex

Nasal Challenge with LPS Stimulates the Release of Macrophage Inflammatory Protein 1 alpha

Background: Bacterial infections can cause a variety of airway diseases. Toll-like receptors (TLRs) directly respond to the presence of microbes and partake in the innate immune defense. TLR4 is activated by lipopolysaccharide (LPS), and has been detected in sinonasal tissue, epithelial cells and various inflammatory cells. Macrophage inflammatory protein 1 alpha (MIP-1 alpha) is a chemokine relea

Stroke induces widespread changes of gene expression for glial cell line-derived neurotrophic factor family receptors in the adult rat brain

Gene expression for glial cell line-derived neurotrophic factor (GDNF) family ligands and receptors was analyzed with in situ hybridization after two focal ischemic insults of different severities. Focal ischemia was induced in rats by either 30 min or 2 h of middle cerebral artery occlusion (MCAO), causing damage to the striatum only, or involving also the parietal cortex, respectively. We found

Locating nanowire heterostructures by electron beam induced current

Electron beam induced current ( EBIC) in a scanning electron microscope ( SEM) was used to identify the positions of heterostructures in InAs/InP nanowires. Composite SEM and EBIC images were used to locate heterostructures and quantum dots in the nanowires, and used in subsequent electron beam lithography to align local gate electrodes to these quantum dots. This has made it possible to use indiv

A Feedback Scheduler for Real-Time Controller Tasks

The problem studied in this paper is how to distribute computingresources over a set of realtime control loops in order to optimizethe total control performance. Two subproblems are investigated: howthe control performance depends on the sampling interval, and how arecursive resource allocation optimization routine can be designed.Linear quadratic cost functions are used as performance indicators.

Comparison of different extraction techniques for isolation of antioxidants from sweet grass (Hierochloe odorata)

Strong antioxidants, 5,8-dihydroxycoumarin and 5-hydroxy-8-O-beta-D-glucopyranosyl-benzopyranone were extracted from sweet grass (Hierochloe odorata L.) by using Soxhlet (SE), microwave-assisted (MAE) and supercritical fluid carbon dioxide (SFE) extractions at different extraction schemes and parameters. One-step MAE gave the most concentrated extract with 8.15% of 5,8-dihydroxycoumarin (extract y

Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells

Insulin secretion is controlled by the beta cell's metabolic state, and the ability of the secretory granules to undergo exocytosis increases during glucose stimulation in a membrane potential-independent fashion. Here, we demonstrate that exocytosis of insulin-containing secretory granules depends on phosphatidylinositol 4-kinase (PI 4-kinase) activity and that inhibition of this enzyme suppresse

Design issues and priorities in team and nonpharmacological arthritis care research

Nonpharmacologic and team care research present unique design challenges. Nonpharmacologic care by nature is multifaceted and complex. Rarely do patients receive an intervention in isolation. The delivery of a single or group of interventions can be provided by one provider but is frequently provided by teams. Therefore, it is imperative that clinical researchers design studies that evaluate singl

Analysing the Moran effect and dispersal: their significance and interaction in synchronous population dynamics

Population synchrony over various geographical scales is known from a large number of taxa. Three main hypotheses have been put forward as explanations to this phenomenon. First, correlated environmental disturbances (so called Moran effect). Moran showed that at least for linear models, the population synchrony would exactly match that of the corresponding environment. Second, the migration, or d

Prostate-specific antigen (PSA) protein does not affect growth of prostate cancer cells InVitro or prostate cancer xenografts in vivo

BACKGROUND. Prostate-specific antigen (PSA) is produced in high amounts by normal and malignant prostate cancer cells. PSA is a serine protease with substrates that include semenogelin I and II, insulin-like growth factor binding protein 3, fibronectin, and laminin. PSA, via its enzymatic activity, may play a role in growth, invasion, and metastasis of prostate cancer cells. Recent data also sugge

Introduction of human papillomavirus (HPV) vaccination in Sweden

The Swedish National Board of Health and Welfare (NBH) decided that a vaccine that protects against cervical cancer caused by human papillomavirus (HPV) should be included in the childhood vaccination directive as a nationwide-programme targeting 12-yearold girls from 2010 as a part of the school-health programme. Currently, vaccination of girls 13-18 years of age is covered by the public insuranc

An amperometric biosensor based on laccase immobilized in polymer matrices for determining phenolic compounds

An amperometric enzyme electrode based on laccase for determining phenolic compounds is proposed. The following three types of polymer materials were used for enzyme immobilization on the surface of a glassy-carbon electrode: positively charged cetyl ethyl poly (ethyleneimine) (CEPEI) and negatively charged commercial Nafion and Eastman AQ 29D polymers. The advantages and disadvantages of each of

Large eddy simulations of a turbulent thermal plume

Large eddy simulations of a three-dimensional turbulent thermal plume in an open environment have been carried out using a self-developed parallel computational fluid dynamics code SMAFS (smoke movement and flame spread) to study the thermal plume's dynamics including its puffing, self-preserving and air entrainment. In the simulation, the sub-grid stress was modeled using both the standard Smagor

Suppression Pattern of Neutral Pions at High Transverse Momentum in Au plus Au Collisions at root S-NN=200 GeV and Constraints on Medium Transport Coefficients

For Au + Au collisions at 200 GeV, we measure neutral pion production with good statistics for transverse momentum, p(T), up to 20 GeV/c. A fivefold suppression is found, which is essentially constant for 5 < p(T) < 20 GeV/c. Experimental uncertainties are small enough to constrain any model-dependent parametrization for the transport coefficient of the medium, e. g., in the parton quenching mode