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Expression of human all-trans-retinoic acid receptor beta and its ligand-binding domain in Escherichia coli

all-trans-Retinoic acid, one of the hormonally active derivatives of vitamin A, occurs physiologically in plasma at a concentration below 10 nmol/l. The methods currently used for its quantification are based on HPLC, need about 1 ml of serum, are relatively laborious and thus not well suited for mass analysis. The affinity and specificity of retinoic acid receptors for all-trans-retinoic acid enc

The FERRUM project: improved experimental oscillator strengths in CrII

We report absolute oscillator strengths for 119 Cr II transitions in the wavelength region 2050-4850 angstrom. The transition probabilities have been derived by combining radiative lifetimes, measured with time- resolved laser induced fluorescence, and branching fractions from intensity calibrated Fouirer transform spectrometer data. New radiative lifetimes for the 3d(4)(D-5)4p F-4, D-4 and P-6 te

The Recontextualisation of Social Pedagogy. A study of three curricula in the Netherlands, Norway and Ireland.

Popular Abstract in Swedish Avhandlingens syfte är att beskriva, analysera och jämföra rekontextualiseringen av socialpedagogik i tre olika curriculum; I Nijmegen (Nederländerna), Lillehammer (Norge) och Sligo (Irland). Rekontextualisering, ett begrepp hämtat från Basil Bernstein, syftar på den transformation som sker när socialpedagogik flyttas in i ett undervisningssammanhang. Materialet bestårThe purpose of this thesis is to describe, analyse, and compare the recontextualisation of social pedagogy in three different curricula; in Nijmegen (NL), Lillehammer (N), and Sligo (IRL). The curricula represent different academic orientations and are located in different social-political contexts. The recontextualisation of social pedagogy, the concept derived from the works of Basil Bernstein,

Bootstrap control

In this paper, we present a new way to control linear stochastic systems. The method is based on statistical bootstrap techniques. The optimal future control signal is derived in such a way that unknown noise distribution and uncertainties in parameter estimates are taken into account. This is achieved by resampling from existing data when calculating statistical distributions of future process va

Disruption of the microbial food web and inhibition of metazooplankton development in the presence of iron- and DOM-stimulated Baltic Sea cyanobacteria

Summer N-2-fixing cyanobacterial blooms are a common feature in the Baltic Sea, and the occurrence of Nodularia spumigena toxic blooms is of particular concern. Cyanobacterial blooms can be favoured by certain conditions including high concentrations of dissolved organic matter, which may increase the availability of iron critical for N-2 fixation. Cyanobacteria may negatively affect grazers becau

Particle number projection in the macroscopic-microscopic approach

We perform nuclear ground-state pairing calculations with the monopole pairing interaction. The particle number fluctuations are taken into account by the particle number projection method, with variation after projection. The pairing-correction energies obtained in this approach are compared to the BCS-model results. We discuss extensively how to properly incorporate different pairing models in g

Spectroscopic techniques for photodynamic therapy dosimetry

Popular Abstract in Swedish Denna avhandling handlar till stora delar om fotodynamisk tumörterapi (PDT). PDT har sedan början av förra århundradet undersökts som ett tänkbart alternativ till strålningsbehandling, kirurgi och kemoterapi för behandling av cancertumörer i kroppen. Precis som namnet antyder involverar metoden en fotodynamisk reaktion. För att denna reaktion skall ske behövs tre kompoPhotodynamic therapy (PDT) as a cancer treatment modality relies on the simultaneous presence of three components; light, photosensitiser and oxygen. Once excited by the light, the photosensitiser can interact with oxygen, leading to the formation of toxic oxygen species. These reactive substances induce cellular damage within the irradiated tissue volume. PDT has been investigated for treating ma

Cause, effect, and fake causation

The possibility of apparently negative causation has been discussed in a number of recent works on causation, but the discussion has suffered from being scattered. In this paper, the problem of apparently negative causation and its attempted solutions are examined in more detail. I discuss and discard three attempts that have been suggested in the literature. My conclusion is negative: Negative ca

Chromosomal aberrations and SCEs as biomarkers of cancer risk

Previous studies have suggested that the frequency of chromosomal aberrations (CAs), but not of sister chromatid exchanges (SCEs), predicts cancer risk. We have further examined this relationship in European cohorts comprising altogether almost 22,000 subjects, in the framework of a European collaborative project (CancerRiskBiomarkers). The present paper gives an overview of some of the results of

Upconversion luminescence of CdTe nanoparticles

Efficient upconversion luminescence is observed from CdTe nanoparticles in solution and precipitated as solids. In the solids, the upconversion luminescence spectrum is significantly red shifted relative to the photoluminescence spectrum, whereas in solution, there is very little spectral shift. The upconversion luminescence exhibits a near-quadratic laser power dependence, both at room temperatur

The Role of Matrix Metalloproteinases in Leukocyte Transmigration in Murine Experimental Autoimmune Encephalomyelitis

Murine experimental autoimmune encephalomyelitis (EAE) is a commonly used model in the investigation of the human disease multiple sclerosis (MS), a debilitating inflammatory disease of the central nervous system (CNS). MS and EAE involve multiple steps, primarily, auto-antigenic leukocyte (mainly T-cells and macrophages) crossing the blood-brain barrier and later their invasion into the CNS where

What Determines the Costs of Repair and Rehabilitation of Flexor Tendon Injuries in Zone II? A Multiple Regression Analysis of Data From Southern Sweden.

The epidemiology and costs of repair and rehabilitation of zone 11 flexor tendon injuries in 135 patients from the southern part of Sweden were analysed. The little finger was most frequently injured (43%), usually with a knife (46%), and 30% of the injuries were work related. Total median costs within the health-care sector for the injuries were SEK 48,500 (1 EURO = 9.23 SEK, 4/1/2002). Costs in