Filtyp
Phenotypic changes of myeloid cells are critical to the regulation of premature aging, development of cancer, and responses to infection. Heme metabolism has a fundamental role in the regulation of myeloid cell function and activity. Here, we show that deletion of heme oxygenase-1 (HO-1), an enzyme that removes heme, results in an impaired DNA damage response (DDR), reduced cell proliferation, and
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate
BACKGROUND: Cardiac rehabilitation (CR) programs addressing risk factor management, educational interventions, and exercise contribute to reduce mortality after myocardial infarction (MI). However, the fulfillment of guideline-recommended CR targets is currently unsatisfactory. eHealth, i.e., the use of electronic communication for healthcare, including the use of mobile smartphone applications co
In weed management, using native parasites to control exotic weeds is considered a better alternative than classical biological control. But the risk must be assessed because of the potential damage caused by these agents. We conducted this project to investigate the mechanism driving the choice of a native obligate parasite, Cuscuta australis, between the exotic, Humulus scandens, and native plan
Wernicke encephalopathy is a condition in which thiamine deficiency causes cognitive dysfunction, ataxia and eye motor abnormalities. The condition is potentially reversible if treated with high doses of intravenous thiamine (vitamin B1). The video head impulse test, in which the vestibulo-ocular reflex is tested, can reveal an early specific sign of selective dysfunction in the medial vestibular
Determining the pKa of key functional groups is critical to understanding the pH-dependent behavior of biological proteins and peptide-based biomaterials. Traditionally, ¹H NMR spectroscopy has been used to determine the pKa of amino acids; however, for larger molecules and aggregating systems, this method can be practically impossible. Previous studies concluded that the C-D stretches in Raman ar
Long-term stability of endosseous implants depends on successful bone formation, ingrowth and adaptation to the implant. Specifically, it will define the mechanical properties of the newly formed bone-implant interface. 3D imaging during mechanical loading tests (in situ loading) can improve the understanding of the local processes leading to bone damage and failure. In this study, titanium screws
Weathering rates are of considerable importance in estimating the acidification sensitivity and recovery capacity of soil and are thus important in the assessment of the sustainability of forestry in a time of changing climate and growing demands for forestry products. In this study, we modelled rates of weathering in mineral soil at two forested sites in southern Sweden included in a monitoring n
An overview of the insertion devices (ID) activities at MAX IV Laboratory will be presented. This paper describes the current status of the MAX IV insertion devices and the first commissioning results of some of the first 12 IDs installed at the three accelerators in MAX IV laboratory. The IDs are two Elliptically Polarizing Undulators (EPU), two In-Vacuum Undulators (IVU) and one In-vacuum wiggle
This article centres on the modal properties of recommendations. Using data from the genre of wine tasting notes, it argues that a recommendation is understood in relation to its role in the social and discursive practice in which it occurs. Recommendations are profiled against two layers of modal grounding in the communicative situation. At the discourse level, recommendations express a weakly de
Wine culture is a complex phenomenon of increasing importance in modern society, and it combines the joys of wine appreciation with the frustrations of trying to verbally communicate sensory impressions. While wine appreciation is traditionally characterized as joyously convivial in its social dimension, sensory impressions remain eminently private. This contrast explains why the language used to
Small gap wigglers become more and more attractive to produce high photon fluxes in the hard X-ray photon range. They use magnet blocks of high magnetization which resists much better to heating (baking, synchrotron radiation) than in the past, produce high magnetic field with numerous periods and are very compact. They also are a very good alternative to superconducting technology which requires
A commercial scientific camera has been adapted and characterized at the SOLEIL Synchrotron with the aim to improve the acquisition capabilities on the soft X-ray coherent scattering experimental station at SEXTANTS beamline. This device is equipped by the last generation of back side illuminated scientific CMOS (BSI-sCMOS) of 2048 by 2048 pixels of 11 μm2 able to acquire low noise images with a f
A novel optical design for a flexible SAXS beamline at a modern synchrotron has been implemented for the CoSAXS beamline at the 3GeV ring at the MAX TV Laboratory. The performance of the beamline has been simulated through combined ray tracing and wave propagation with the code xrt taking into account the low emittance and highly coherent beam of MAX TV and the short inter-optics distances of the
The double compression expansion engine (DCEE) is a promising concept for high engine efficiency while fulfilling the most stringent European and US emission legislation. The complete thermodynamic cycle of the engine is split among several cylinders. Combustion of fuel occurs in the combustion cylinder and in the expansion cylinder the exhaust gases are over expanded to obtain high efficiency. A
The combustion processes of three injection strategies in a light-duty (LD) diesel engine at a medium load point are captured with a high speed video camera. A double-pilot/main/single-post injection strategy representative of a LD Euro 6 calibration is considered as the reference. There is a modest temporal spacing (dwell) after the first pilot (P1) and second pilot (P2). A second strategy, "A,"
The double compression-expansion engine concepts (DCEE) are split-cycle concepts where the compression, combustion, expansion and gas exchange strokes occur in two or more different cylinders. Previous simulation studies reveal there is a potential to improve brake efficiency with these engine concepts due to improved thermodynamic and mechanical efficiencies. As a continuation of this project thiThe double compression-expansion engine concepts (DCEE) are split-cycle concepts where the compression, combustion, expansion and gas exchange strokes occur in two or more different cylinders. Previous simulation studies reveal there is a potential to improve brake efficiency with these engine concepts due to improved thermodynamic and mechanical efficiencies. As a continuation of this project thi
