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Shiga toxin is the main virulence factor of enterohemorrhagic Escherichia coli, a non-invasive pathogen that releases virulence factors in the intestine, causing hemorrhagic colitis and, in severe cases, hemolytic uremic syndrome (HUS). HUS manifests with acute renal failure, hemolytic anemia and thrombocytopenia. Shiga toxin induces endothelial cell damage leading to platelet deposition in thromb

The cross section of a top-quark pair produced in association with a photon is measured in proton-proton collisions at a centre-of-mass energy of s=8 TeV with 20.2 fb−1 of data collected by the ATLAS detector at the Large Hadron Collider in 2012. The measurement is performed by selecting events that contain a photon with transverse momentum pT > 15 GeV, an isolated lepton with large transverse mom

Observables sensitive to the anomalous production of events containing hadronic jets and missing momentum in the plane transverse to the proton beams at the Large Hadron Collider are presented. The observables are defined as a ratio of cross sections, for events containing jets and large missing transverse momentum to events containing jets and a pair of charged leptons from the decay of a Z/ γ∗bo

We use two-dimensional numerical simulations to study dense suspensions of non-Brownian hard particles using the Critical Load Model (CLM) under constant confining pressures. At constant packing fraction this simple model shows shear thickening as the tangential forces get activated upon increased shear stresses. By parameterizing a simple binary system of frictional and nonfrictional particles of

Aerosol-And propane bottles for consumers, including hairspray, lubricants, etc. were tested for exposure from fire. The tested bottles had a volume between 15- 400 ml of product mixed with propane and bottles with propane only containing 0.35, 0.45, 5 and 6 kg of propane. The aerosol-And propane bottles were exposed to a heptane pool fire, corresponding to properties of common available flammable

Conventionally, radiofrequency (RF) coils used for magnetic resonance imaging (MRI) are electrically small and designed for nearfield operation. Therefore, existing antenna design techniques are mostly irrelevant for RF coils. However, the use of higher frequencies in ultrahigh field (UHF) MRI allows for antenna design techniques to be adapted to RF coil designs. This study proposes the use of par

Osteopontin (OPN) is involved in various physiological processes and also implicated in multiple pathological states. It has been suggested that OPN may have a role in type 2 diabetes (T2D) by protecting pancreatic islets and interaction with incretins. However, the regulation and function of OPN in islets, especially in humans, remains largely unexplored. In this study, we performed our investiga

This paper contributes to the literature on internal migration by estimating parameters for push and pull factors by modelling the complete migration decision. Using data based on individuals linked between the complete Swedish censuses of 1880 and 1890, we consider both the push factors which determined whether an individual choose to leave their origin and the pulls factors which attracted migra

Chemical hypersensitivity is an immunological response towards foreign substances, commonly referred to as sensitizers, which gives rise primarily to the clinical symptoms known as allergic contact dermatitis. For the purpose of mitigating risks associated with consumer products, chemicals are screened for sensitizing effects. Historically, such predictive screenings have been performed using anim

The effects of fuel properties on the performance and emissions of an engine running in partially premixed combustion mode were investigated using nine test fuels developed in the gasoline boiling point range. The fuels covered a broad range of ignition quality and fuel chemistry.The fuels were characterized by performing a load sweep between 1 and 12 bar gross IMEP at 1000 and 1300 rpm. A heavy d

Contact allergy induced by certain chemicals is a common health concern, and several alternative methods have been developed to fulfill the requirements of European legislation with regard to hazard assessment of potential skin sensitizers. However, validated methods, which provide information about the potency of skin sensitizers, are still lacking. The cell-based assay Genomic Allergen Rapid Det

With the shift of focus of the regulatory bodies, from fixed process conditions towards flexible ones based on process understanding, model-based optimization is becoming an important tool for process development within the biopharmaceutical industry. In this paper, a multi-objective optimization study of separation of three insulin variants by reversed-phase chromatography (RPC) is presented. The

The operating range in HCCI mode is limited by the excessive pressure rise rate and therefore high combustion induced noise. The HCCI range can be extended with turbocharging which enables increased dilution of the charge and thus a reduction of combustion noise. When the engine is turbocharged the intake charge will have a high temperature at increased boost pressure and can then be regulated in The operating range in HCCI mode is limited by the excessive pressure rise rate and therefore high combustion induced noise. The HCCI range can be extended with turbocharging which enables increased dilution of the charge and thus a reduction of combustion noise. When the engine is turbocharged the intake charge will have a high temperature at increased boost pressure and can then be regulated in