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The orientation towards grand societal challenges can be seen as a new wave or paradigm for innovation policy. Such policy aims at system-wide transformation and is often referred to as system innovation policy. While insights from transition studies have provided novel and useful rationales for innovation policy targeting system-wide transformation, it remains unclear how to design, implement and

The role of dietary fiber in the cause of acute appendicitis was evaluated. By means of food diaries the average daily fiber consumption was determined in 31 patients with acute appendicitis and in 30 control patients, matched for age and sex. The average daily dietary fiber intake was 17.4 g in the group with appendicitis and 21.0 g in the control group. The difference is statistically significan

A reduction in the number of postoperative bed days for patients who underwent appendectomy led to a study of changes in hospital costs of appendectomies for the years 1955, and 1965, and 1975. No significant changes were found in the total hospital costs. However, the postoperative costs decreased by 36 percent from 1955 to 1975 due to a decrease in the mean duration of hospital stay. During the

In 173 patients (study group), undergoing appendicectomy because of suspected acute appendicitis, normal saline solution, in the amount of 10 ml per 1000 g of patient weight, was injected into the peritoneal cavity before closing the incision. A control group of patients undergoing appendicectomy was selected, matched for age and sex. The mean observation period was five years for both groups. One

When acute appendicitis progresses to perforation, the consequences often lead to prolonged and difficult convalescence or even to death. It was of interest therefore to study a sample of patients with acute appendicitis and to investigate what factors appear to affect perforation in acute appendicitis. A series is presented of 248 patients with acute appendicitis. Seventy-seven of these were foun

The role of obstruction in the pathogenesis of acute appendicitis was studied by measuring the pressure in the appendix peroperatively in 33 patients undergoing appendectomy because of suspected acute appendicitis. The technique involved insertion of a fine needle via the apex into the lumen of the appendix and measurement of the hydrostatic pressure required to inject a saline solution. In all si

The high negative exploration rate in patients with suspected acute appendicitis is the main compelling reason to improve the accuracy in managing patients with acute abdominal pain. In this article, data from a prospective study on a group of patients undergoing acute appendectomy were used to devise a scoring system for the purpose of differentiating between the patients with an acute appendicit

The significantly different age-specific incidence of acute appendicitis between males and females in the second, third and fourth decades of life led to a study of the frequency of acute appendicitis and the degree of appendiceal inflammation found at operation in the different phases of the menstrual cycle. The frequency of acute appendicitis was almost twice as high in the luteal phase as in th

The incidence during the last decades of acute appendicitis and the number of appendicectomies in the elderly, 60 years of age and older were studied. In addition, the incidence of the disease and of appendicectomy and the preoperative findings were studied in a well defined population during the twelve year period from 1969 to 1980. The results showed that there was no increase in the sex- and ag

The significantly higher incidence of removal of a normal appendix in females in the second, third and fourth decades of life for suspected acute appendicitis lead to a study of the frequency of appendicectomy and the peroperative findings at the time of surgery in patients in different phases of the menstrual cycle. The results showed that the frequency of acute appendicitis in the luteal phase w

From the results of this study, it can be concluded that a difference is noted in the frequency of acute appendicitis and the number of appendectomies performed in different phases of the menstrual cycle. Therefore, the female sex hormones might play an important role in the cause of acute appendicitis. This is further supported by the lower sex specific incidence of acute appendicitis for women i

Abdominal muscular contractions may have a protective influence against the development of indirect inguinal hernia. A portion of the transversus abdominus muscles acts on the internal inguinal rings and produces a closure mechanism during voluntary abdominal muscular activity. It follows, therefore, that injury or inactivation of this mechanism may be an etiologic factor in the development of ind

The incidence of right inguinal hernia is significantly greater in patients who have undergone appendectomy than in the general population. The most likely cause of such hernias is injury to the segmental nerve supply to the inguinal musculature. The choice of incision at appendectomy may therefore be important, and the surgeon should avoid injury to the nerve branches and important structures in

The relationship of acute appendicitis occurring previous to cancer in colon and rectum was studied in the consecutive records of 561 patients, of 40 years of age and older, operated upon with an appendectomy because of acute appendicitis. Sixteen (2.9%) of these patients were readmitted within three years because of a carcinoma in colon or rectum. The incidence of carcinoma in the colon and rectu

The incidence of acute appendicitis and the total number of appendectomies performed in the adult population admitted to our medical center are both decreasing. The cause is not clear. Better nutrition and the wide-spread use of antibiotics are two possible factors which come to mind, but we know of no scientific evidence that these are responsible. There has been a slight decrease in the mean die